Protein Overview: ATS1

General Information:
Name(s) found:	ATS1 / YAL020C [SGD]
Description(s) found: Found 22 descriptions. SHOW ALL	Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle [SGD]
Organism:	Saccharomyces cerevisiae
Length:	333 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IPI]
Biological Process:	microtubule cytoskeleton organization [IGI][IMP] budding cell bud growth [IGI][IMP] tRNA modification [IMP] microtubule-based process [IGI][ISS]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSCVYAFGSN GQRQLGLGHD EDMDTPQRSV PGDDGAIVRK IACGGNHSVM LTNDGNLVGC  60
   61 GDNRRGELDS AQALRQVHDW RPVEVPAPVV DVACGWDTTV IVDADGRVWQ RGGGCYEFTQ 120
  121 QHVPLNSNDE RIAVYGCFQN FVVVQGTRVY GWGSNTKCQL QEPKSRSLKE PVLVYDTGSV 180
  181 AVDYVAMGKD FMVIVDEGGR IVHASGRLPT GFELKQQQKR HNLVVLCMWT SIHLWNARLN 240
  241 TVESFGRGTH SQLFPQERLD FPIVGVATGS EHGILTTANQ EGKSHCYNVY CWGWGEHGNC 300
  301 GPQKASQPGL QLVGQYSGKP RVFGGCATTW IVL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ATS1 DPH1 DPH2 KTI11
View Details	Krogan NJ, et al. (2006)		ATS1 KTI11

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SPC98	ATS1	1	Unpublished Fields Lab Data
View Screen	GBP2	ATS1	1	Unpublished Fields Lab Data
View Screen	GTS1	ATS1	1	Unpublished Fields Lab Data
View Screen	CTF13	ATS1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..333]	PSI-BLAST	96.0	Regulator of chromosome condensation RCC1

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
binding	1.79978015066238	bayes_pls_golite062009
Ran guanyl-nucleotide exchange factor activity	1.12611051197363	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	1.05993294531818	bayes_pls_golite062009
GTPase regulator activity	1.03758696380346	bayes_pls_golite062009
ligase activity	0.957134518791255	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	0.947267197207143	bayes_pls_golite062009
small GTPase regulator activity	0.882132361980766	bayes_pls_golite062009
protein binding	0.775788303004353	bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity	0.642436223706285	bayes_pls_golite062009
catalytic activity	0.261970921089142	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2