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Protein Overview: slo-PN

General Information:
Name(s) found: slo-PN / FBpp0100095 [FlyBase]
Description(s) found:
Found 17 descriptions.
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  • The gene slowpoke is referred to in FlyBase by the symbol Dmel\slo (CG10693, FBgn0003429). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20490086..20534111. It has the cytological map location 96A14-96A17. There is experimental evidence that it has the molecular function</span>: protein binding; calcium-activated potassium channel activity. There is experimental evidence that it is involved in the biological process</span>: male courtship behavior, veined wing generated song production; circadian rhythm; potassium ion transport; circadian behavior; response to drug. 38 alleles are reported. The phenotypes of these alleles are annotated with: neuron; indirect flight muscle. It has 18 annotated transcripts and 18 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1200 amino acids

    Gene Ontology:
    Cellular Component: voltage-gated potassium channel complex [IEA]
    membrane [IDA]
    neuronal cell body [IDA]
    neuron projection [IDA]
    plasma membrane [NAS]
    Biological Process: potassium ion transport [IDA][NAS]
    transmembrane transport [IEA]
    response to drug [IMP]
    metabolic process [IEA]
    male courtship behavior, veined wing generated song production [IMP][NAS]
    circadian behavior [IMP]
    circadian rhythm [IMP]
    Molecular Function: calcium-activated potassium channel activity [IDA][NAS]
    voltage-gated potassium channel activity [IEA]
    protein binding [IPI]
    catalytic activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASGLIDTNF SSTLANGMSG CDQSTVESLA DDPTDSPFDA DDCLKVRKYW CFLLSSIFTF  60
   61 LAGLLVVLLW RAFAFVCCRK EPDLGPNDPK QKEQKASRNK QEFEGTFMTE AKDWAGELIS 120
  121 GQTTTGRILV VLVFILSIAS LIIYFVDASS EEVERCQKWS NNITQQIDLA FNIFFMVYFF 180
  181 IRFIAASDKL WFMLEMYSFV DYFTIPPSFV SIYLDRTWIG LRFLRALRLM TVPDILQYLN 240
  241 VLKTSSSIRL AQLVSIFISV WLTAAGIIHL LENSGDPLDF NNAHRLSYWT CVYFLIVTMS 300
  301 TVGYGDVYCE TVLGRTFLVF FLLVGLAMFA SSIPEIIELV GSGNKYGGEL KREHGKRHIV 360
  361 VCGHITYESV SHFLKDFLHE DREDVDVEVV FLHRKPPDLE LEGLFKRHFT TVEFFQGTIM 420
  421 NPIDLQRVKV HEADACLVLA NKYCQDPDAE DAANIMRVIS IKNYSDDIRV IIQLMQYHNK 480
  481 AYLLNIPSWD WKQGDDVICL AELKLGFIAQ SCLAPGFSTM MANLFAMRSF KTSPDMQSWT 540
  541 NDYLRGTGME MYTETLSPTF IGIPFAQATE LCFSKLKLLL LAIEIKGAEE GADSKISINP 600
  601 RGAKIQANTQ GFFIAQSADE VKRAWFYCKA CHEDIKDETL IKKCKCKNLT VQPRSKFDDL 660
  661 DEHHPAPTFT PPELPKRVHV RGSVSGDITR DREDTNLLNR NVRRPNGTGN GTGGMHHMNN 720
  721 TAAAAAAAAA AGKQVNKVKP TVNVSRQVEG QVISPSQYNR PTSRSSGTGT QNQNGGVSLP 780
  781 AGIADDQSKD FDFEKTEMKY DSTGMFHWSP AKSLEDCILD RNQAAMTVLN GHVVVCLFAD 840
  841 PDSPLIGLRN LVMPLRASNF HYHELKHVVI VGSVDYIRRE WKMLQNLPKI SVLNGSPLSR 900
  901 ADLRAVNVNL CDMCCILSAK VPSNDDPTLA DKEAILASLN IKAMTFDDTI GVLSQRGPEF 960
  961 DNLSATAGSP IVLQRRGSVY GANVPMITEL VNDSNVQFLD QDDDDDPDTE LYLTQPFACG1020
 1021 TAFAVSVLDS LMSTTYFNQN ALTLIRSLIT GGATPELELI LAEGAGLRGG YSTVESLSNR1080
 1081 DRCRVGQISL YDGPLAQFGE CGKYGDLFVA ALKSYGMLCI GLYRFRDTSS SCDASSKRYV1140
 1141 ITNPPDDFSL LPTDQVFVLM QFDPGLEYKP PAVRAPAGGR GTNTQGSGVG GGGSNKDDNS1200
 1201

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..395] PSI-BLAST 66.0 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    2 View Details [396..694] PSI-BLAST 23.522879 Potassium channel-related protein MthK
    3 View Details [695..790] deduced N/A No confident structure predictions are available.
    4 View Details [791..1200] FFAS03 2.8 Potassium channel-related protein MthK

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • potassium channel activity
    		•  7.19795882959285 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  7.02492819589858 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  6.90465650760629 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  6.33923365642046 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  6.21728899427189 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  6.20461120293277 bayes_pls_golite062009
  • cation channel activity
    		•  5.56619080264703 bayes_pls_golite062009
  • ion channel activity
    		•  5.01725373023133 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  4.95840588988444 bayes_pls_golite062009
  • channel activity
    		•  4.95840588988444 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  4.90604391861681 bayes_pls_golite062009
  • gated channel activity
    		•  4.76975011621094 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  2.96809690970616 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.73807350248822 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.67515190518646 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.33083670641501 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.13014428099026 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  2.01726075025767 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.91774061209278 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • potassium ion transmembrane transporter activity
    		•  1.57069429249737 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  1.19349599687216 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.15786007823324 bayes_pls_golite062009
  • sterol transporter activity
    		•  1.14689358041007 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.10146351042336 bayes_pls_golite062009
  • signal transducer activity
    		•  1.10146351042336 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.82673050487418 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.824879127880521 bayes_pls_golite062009
  • transporter activity
    		•  0.793769336118517 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.707555098275754 bayes_pls_golite062009
  • receptor activity
    		•  0.669414726094584 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.635891484075352 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.555188550031886 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.554841724526358 bayes_pls_golite062009
  • protein binding
    		•  0.507836099271263 bayes_pls_golite062009
  • binding
    		•  0.343109880193463 bayes_pls_golite062009
  • DNA binding
    		•  0.325332812205271 bayes_pls_golite062009
  • copper ion binding
    		•  0.2470667568593 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.239024094835991 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • potassium channel activity
    		•  7.202408784466 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  7.02827897972893 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  6.87383718666495 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  6.34341135807817 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  6.22204288894013 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  6.2094216063314 bayes_pls_golite062009
  • cation channel activity
    		•  5.57352831106363 bayes_pls_golite062009
  • ion channel activity
    		•  5.02493108579252 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  4.96639582515843 bayes_pls_golite062009
  • channel activity
    		•  4.96639582515843 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  4.91395304996323 bayes_pls_golite062009
  • gated channel activity
    		•  4.77703666141432 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  2.89387517936987 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.72791814044378 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.67765801390314 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.35275220137267 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.09218991631308 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.91294607339699 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  1.67790172484722 bayes_pls_golite062009
  • catalytic activity
    		•  1.65938032155125 bayes_pls_golite062009
  • potassium ion transmembrane transporter activity
    		•  1.30544811445848 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.13917599808599 bayes_pls_golite062009
  • signal transducer activity
    		•  1.13917599808599 bayes_pls_golite062009
  • sterol transporter activity
    		•  1.1340080668117 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  0.87204519429381 bayes_pls_golite062009
  • transporter activity
    		•  0.852768781758211 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.840542793047449 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.742068313615785 bayes_pls_golite062009
  • receptor activity
    		•  0.692499944712409 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.688412180298523 bayes_pls_golite062009
  • protein binding
    		•  0.610214344005539 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.588406835418016 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.576415677502347 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.501691937400574 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.501572482308387 bayes_pls_golite062009
  • binding
    		•  0.445541100906877 bayes_pls_golite062009
  • DNA binding
    		•  0.335306484866611 bayes_pls_golite062009
  • copper ion binding
    		•  0.253235147806174 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.248538814281934 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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