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Protein Overview: cng-3

General Information:
Name(s) found: cng-3 / CE37910 [WormBase]
Description(s) found:
Found 13 descriptions.
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  • WBGene00000563 locus:cng-3 status:Partially_confirmed UniProt:Q7Z205 protein_id:CAD91630.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 626 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: ion transport [IEALink to PubMed article]
    Molecular Function: ion channel activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTHSAQKLP NLHERKRRMS KKPDDDDLIP QHFEYENQYE KWRAANPRIE YDFSVDESGY  60
   61 IYWIWTFFVV CGCLYNIIVL SVLAFENIRY AYIEKILPIN IAFDTVFLFD IILRSMLSFY 120
  121 EDGVLITSFS ETWRHYVHSF YFAIDLLAIF PFDYLLIRKT SAAFCRLNRF LKIYRIANFI 180
  181 AQSYGKLTQV TISLSKIFTA CFLLFHVNAC VFYIISVNSD TSSWDGVNAT FDDDEYLPWP 240
  241 YTPEKITDAY FVGCDGRTDC YNPYFYYDEA REDHLVELYH FWRTDNRTHI YNFSQFTKEY 300
  301 TLSMYWSAMT MTTLGEQPAP NTSLQNAFEI VNTLAGLLLF AVIMGSIGDL VANANAVKTF 360
  361 WQTLMDGLKQ YMTYRNLNER LQTKVLKYCE YEMAEETIMK EHEVRDELPA KLYGHVTTSI 420
  421 IGASLVRSPL FRASERSFLN DISQLLEPHY FCPGDVVIEK GQLCSSMFII VCGQMVEITE 480
  481 DNEIDHFEGE ILGDVNLIWF NNHLNHNRHQ HNVISSAFSQ IHMLSRDDFF KVLSSYDPKL 540
  541 KRRLCDVAFY LQRQRGELDD KKRCLSENED IESNLKRLAI DTLELHDKMT EMEEEFWDFS 600
  601 ATAKRKLFES EMVVCDLLNN SQRRSR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..355] FFAS03 5.59 Crystal structure of KvAP-33H1 Fv complex
    2 View Details [356..567] PSI-BLAST 27.522879 HCN2J 443-645 in the presence of cGMP
    3 View Details [568..626] PSI-BLAST 14.522879 No description for 2gauA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cation channel activity
    		•  8.8271544979352 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  8.821528894161 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  8.74133052120115 bayes_pls_golite062009
  • ion channel activity
    		•  8.5319589047463 bayes_pls_golite062009
  • gated channel activity
    		•  8.44554798975713 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  8.43463411234305 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  8.4117395754193 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  8.36000486601638 bayes_pls_golite062009
  • channel activity
    		•  8.32023913192244 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  8.32023913192244 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  8.30986502722514 bayes_pls_golite062009
  • potassium channel activity
    		•  8.23401095904851 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  5.43467612453479 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  5.43467612453479 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  4.88789838906314 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.80939024913503 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.43208330555032 bayes_pls_golite062009
  • transporter activity
    		•  2.77619896060397 bayes_pls_golite062009
  • inward rectifier potassium channel activity
    		•  2.77094691956851 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.65613366364107 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.60593795082679 bayes_pls_golite062009
    2
    Term Confidence Notes
  • cyclic nucleotide-gated ion channel activity
    		•  10.1422916734545 bayes_pls_golite062009
  • intracellular cyclic nucleotide activated cation channel activity
    		•  10.1422916734545 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  9.72053268940283 bayes_pls_golite062009
  • cation channel activity
    		•  9.48749374439976 bayes_pls_golite062009
  • ion channel activity
    		•  9.4846197809463 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  9.3929063879608 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  9.25176207085973 bayes_pls_golite062009
  • channel activity
    		•  9.25176207085973 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  9.2472549851376 bayes_pls_golite062009
  • intracellular cGMP activated cation channel activity
    		•  9.19973076787954 bayes_pls_golite062009
  • gated channel activity
    		•  9.19042473454294 bayes_pls_golite062009
  • cGMP binding
    		•  7.7575871125398 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • cyclic nucleotide binding
    		•  7.37322432929433 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  6.57272328088253 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  6.54930851487319 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.54400173845933 bayes_pls_golite062009
  • GMP binding
    		•  5.49455172024846 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  5.34760703274696 bayes_pls_golite062009
  • potassium channel activity
    		•  5.29889968906368 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  5.1138025954757 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  4.96516802098805 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  4.52895684111035 bayes_pls_golite062009
  • intracellular cAMP activated cation channel activity
    		•  3.95109938608832 bayes_pls_golite062009
  • transporter activity
    		•  3.30740141256752 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.24402760485462 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.22443361822344 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.7487659479534 bayes_pls_golite062009
  • signal transducer activity
    		•  1.7487659479534 bayes_pls_golite062009
  • binding
    		•  1.59096092728475 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.30878085449184 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.839610030740937 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.815055562928958 bayes_pls_golite062009
  • protein binding
    		•  0.81302068072988 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.755486819364628 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  2.88885372623841 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.57662935644785 bayes_pls_golite062009
  • DNA binding
    		•  2.25550504100742 bayes_pls_golite062009
  • transcription factor activity
    		•  1.64588582179037 bayes_pls_golite062009
  • signal transducer activity
    		•  1.42015496657117 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.42015496657117 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.99422680194924 bayes_pls_golite062009
  • protein binding
    		•  0.753698599635855 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.358723864160071 bayes_pls_golite062009
  • transcription activator activity
    		•  0.182501400838027 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0996090941687185 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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