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Protein Overview: nas-23

General Information:
Name(s) found: nas-23 / CE38212 [WormBase]
Description(s) found:
Found 14 descriptions.
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  • WBGene00003542 locus:nas-23 Zinc metalloproteinase nas-23 status:Partially_confirmed UniProt:Q7Z0M7 protein_id:CCD65953.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 537 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: proteolysis [IEALink to PubMed article]
    Molecular Function: meprin A activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    astacin activity [IEALink to PubMed article]
    metallopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFLILVLAG SIGIYGVNLP KIPKLSDLVN PFQQFKLKDI LSTLTALDTP DIAADSAGVS  60
   61 LPKHEYTDRL SSISDLNRSK RDLLFQGDIH LSFEHLSNIV REQLDHSRTK RTAFRNAMYP 120
  121 KTIWLPNVPF ELHGSLSAKS RSSLVAAMAF WEKHTCVAFK KRTSEKVYLL MSGQEEGCWS 180
  181 TVGRDEAQGA QILNIGTGCE MFGITSHEIA HALGLFHEQS RYDRDNYVQI VKSRIAQTNF 240
  241 YDFAVVGKKN METYGQKYDI GSVMHYRPTE FSLDGGNSII AKDVNMQNTM GQFRGPSFID 300
  301 VAKINRHYNC EKNCKNKITC LNGGYQHPKN CKICVCPPGY GGSDCKGIEA SSPAKCTGVL 360
  361 VAGETQRKFT ANIKPNKNAK GIRKCNYHIE APPGKRIVII VDSVIGNCVQ GCYEEGVELK 420
  421 MYEDKTVTGA RFCCKLQKPQ TLISQGNTVP LMLVAGKAQA FVQLRYSTVD GPQNRSPKDG 480
  481 NATSIGVNPF LLEKYQDNSI DSEAIRKEYH IQSDNVNQED FETLVRSEFI DENTADI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..104] deduced N/A No confident structure predictions are available.
    2 View Details [105..284] PSI-BLAST 34.69897 STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
    3 View Details [285..355] deduced N/A No confident structure predictions are available.
    4 View Details [356..537] PSI-BLAST 21.0 Mannose-binding protein associated serine protease 2, MASP2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  4.1917763812737 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.85190688399485 bayes_pls_golite062009
  • metallopeptidase activity
    		•  3.22757426039234 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.98133341931091 bayes_pls_golite062009
  • hydrolase activity
    		•  2.78513171530601 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  2.54952091441017 bayes_pls_golite062009
  • transporter activity
    		•  1.28982382930122 bayes_pls_golite062009
  • binding
    		•  1.19918194301835 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.0688261398267 bayes_pls_golite062009
  • catalytic activity
    		•  0.891187593353827 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.798767221679673 bayes_pls_golite062009
  • protein binding
    		•  0.553658909577001 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.543737159152136 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.492456025063956 bayes_pls_golite062009
  • receptor activity
    		•  0.332822250208465 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.241890854867053 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.136560284009247 bayes_pls_golite062009
  • integrin binding
    		•  0.0945964646680701 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.00533877867882504 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  2.19152785302602 bayes_pls_golite062009
  • peptidase activity
    		•  2.03786631670095 bayes_pls_golite062009
  • protein binding
    		•  1.99839937208979 bayes_pls_golite062009
  • receptor binding
    		•  1.94948331803509 bayes_pls_golite062009
  • transporter activity
    		•  1.35573169203175 bayes_pls_golite062009
  • receptor activity
    		•  1.17703206127603 bayes_pls_golite062009
  • hydrolase activity
    		•  1.12447587972667 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.10435298721188 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.03966651045249 bayes_pls_golite062009
  • endopeptidase activity
    		•  1.03668892056053 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.02450424977847 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.71787375735636 bayes_pls_golite062009
  • metallopeptidase activity
    		•  0.623476257655953 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  0.508669171144608 bayes_pls_golite062009
  • transcription factor binding
    		•  0.30492109086541 bayes_pls_golite062009
  • growth factor activity
    		•  0.190406928940325 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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