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Protein Overview: MME

General Information:
Name(s) found: MME [HGNC (HUGO)]
Description(s) found:
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  • gi|75517798|gb|AAI01659.1| Membrane metallo-endopeptidase [Homo sapiens] [NCBI NR]
  • gi|75516647|gb|AAI01633.1| Membrane metallo-endopeptidase [Homo sapiens] [NCBI NR]
  • pir||HYHUN neprilysin (EC 3.4.24.11) [validated] - human [NCBI NR]
  • gi|29626|emb|CAA68752.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|179860|gb|AAA52294.1| enkephalinase [Homo sapiens] [NCBI NR]
  • gi|167882794|gb|ACA05913.1| membrane metallo-endopeptidase variant 1 [Homo sapiens] [NCBI NR]
  • gi|158256954|dbj|BAF84450.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|128062|sp|P08473.2|NEP_HUMAN RecName: Full=Neprilysin; AltName: Full=Neutral endopeptidase 24.11; Short=Neutral endopeptidase; Short=NEP; AltName: Full=Enkephalinase; AltName: Full=Atriopeptidase; AltName: Full=Common acute lymphocytic leukemia antigen [NCBI NR]
  • gi|119599164|gb|EAW78758.1| membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119599163|gb|EAW78757.1| membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119599162|gb|EAW78756.1| membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119599161|gb|EAW78755.1| membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119599160|gb|EAW78754.1| membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119599159|gb|EAW78753.1| membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|116256333|ref|NP_009220.2| membrane metallo-endopeptidase [Homo sapiens] [NCBI NR]
  • gi|116256331|ref|NP_009219.2| membrane metallo-endopeptidase [Homo sapiens] [NCBI NR]
  • gi|116256329|ref|NP_000893.2| membrane metallo-endopeptidase [Homo sapiens] [NCBI NR]
  • gi|116256327|ref|NP_009218.2| membrane metallo-endopeptidase [Homo sapiens] [NCBI NR]
  • membrane metallo-endopeptidase [HGNC (HUGO)]
  • Neprilysin OS=Homo sapiens GN=MME PE=1 SV=2 [Swiss-Prot]
  • neprilysin (EC 3.4.24.11) [validated] - humangi|29626|emb|CAA68752.1| unnamed protein product [Homo sapiens]gi|179860|gb|AAA52294.1| enkephalinasegi|128062|sp|P08473|NEP_HUMAN Neprilysin (Neutral endopeptidase) (NEP) (Enkephalinase) (Common acute lymph [nrdb_11152004_Chlamydomonas]
  • Neprilysin (Neutral endopeptidase) (NEP) (Enkephalinase) (Common acute lymphocytic leukemia antigen) (CALLA) (Neutral endopeptidase 24.11) (CD10) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • membrane metallo-endopeptidase [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Neprilysin (Neutral endopeptidase 24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • membrane metallo-endopeptidase variant 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Membrane metallo-endopeptidase [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10), isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • enkephalinase [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • RecName: Full=Neprilysin; AltName: Full=Neutral endopeptidase 24.11; Short=Neutral endopeptidase; Short=NEP; AltName: Full=Enkephalinase; AltName: Full=Atriopeptidase; AltName: Full=Common acute lymphocytic leukemia antigen; Short=CALLA; AltName: CD_antig [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=MME Neprilysin [human-ipi-250309-contam.fasta]
  • Membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase) [Homo sapiens] [nr-271106-contam.fasta]
  • Neprilysin (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen) [nr-271106-contam.fasta]
  • IPI:IPI00247063.3|SWISS-PROT:P08473|TREMBL:A8K6U6;B7ZKY6|ENSEMBL:ENSP00000353679;ENSP00000384558|REFSEQ:NP_000893;NP_009218;NP_009219;NP_009220|H-INV:HIT000325326|VEGA:OTTHUMP00000173288 Tax_Id=9606 Gene_Symbol=MME Neprilysin [ipi.HUMAN.fasta.20090807]
  • Tax_Id=9606 Neprilysin [IPI_human_3.26.fasta]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=MME Neprilysin ENSG00000196549 IPI00247063 IPI00654862 IPI00794750 IPI00793397 [drosphohumanreversed.fasta]
  • P08473;A8K6U6;Q3MIX4; RecName: Full=Neprilysin; AltName: Full=Neutral endopeptidase 24.11; AltName: Full=Enkephalinase; AltName: Full=Atriopeptidase; AltName: Full=Common acute lymphocytic leukemia antigen; AltName: CD_antigen=CD10; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Neprilysin OS=Homo sapiens GN=MME [011711_HMR.fasta]
  • IPI:IPI00247063.3|SWISS-PROT:P08473|TREMBL:B7ZKY6;D3DNJ9|ENSEMBL:ENSP00000353679;ENSP00000384558;ENSP00000417079;ENSP00000418525;ENSP00000419653;ENSP00000420389|REFSEQ:NP_000893;NP_009218;NP_009219;NP_009220|H-INV:HIT000325326|VEGA:OTTHUMP00000173288 Tax_Id=9606 Gene_Symbol=MME Neprilysin [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=MME Synonyms=CALLA|CD10|DKFZp686O16152|MGC126681|MGC126707|NEP|SFE neprilysin [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00247063.3|SWISS-PROT:P08473|TREMBL:B7ZKY6|ENSEMBL:ENSP00000353679;ENSP00000417079;ENSP00000418525;ENSP00000419653;ENSP00000420389|REFSEQ:NP_000893;NP_009218;NP_009219;NP_009220|H-INV:HIT000325326|VEGA:OTTHUMP00000212961;OTTHUMP00000212963;OTTHUMP00000212964;OTTHUMP00000212965;OTTHUMP00000212966 Tax_Id=9606 Gene_Symbol=MME Neprilysin [ipi.HUMAN.20110912.fasta]
  • Neprilysin GN=MME [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 750 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKSESQMDI TDINTPKPKK KQRWTPLEIS LSVLVLLLTI IAVTMIALYA TYDDGICKSS  60
   61 DCIKSAARLI QNMDATTEPC TDFFKYACGG WLKRNVIPET SSRYGNFDIL RDELEVVLKD 120
  121 VLQEPKTEDI VAVQKAKALY RSCINESAID SRGGEPLLKL LPDIYGWPVA TENWEQKYGA 180
  181 SWTAEKAIAQ LNSKYGKKVL INLFVGTDDK NSVNHVIHID QPRLGLPSRD YYECTGIYKE 240
  241 ACTAYVDFMI SVARLIRQEE RLPIDENQLA LEMNKVMELE KEIANATAKP EDRNDPMLLY 300
  301 NKMTLAQIQN NFSLEINGKP FSWLNFTNEI MSTVNISITN EEDVVVYAPE YLTKLKPILT 360
  361 KYSARDLQNL MSWRFIMDLV SSLSRTYKES RNAFRKALYG TTSETATWRR CANYVNGNME 420
  421 NAVGRLYVEA AFAGESKHVV EDLIAQIREV FIQTLDDLTW MDAETKKRAE EKALAIKERI 480
  481 GYPDDIVSND NKLNNEYLEL NYKEDEYFEN IIQNLKFSQS KQLKKLREKV DKDEWISGAA 540
  541 VVNAFYSSGR NQIVFPAGIL QPPFFSAQQS NSLNYGGIGM VIGHEITHGF DDNGRNFNKD 600
  601 GDLVDWWTQQ SASNFKEQSQ CMVYQYGNFS WDLAGGQHLN GINTLGENIA DNGGLGQAYR 660
  661 AYQNYIKKNG EEKLLPGLDL NHKQLFFLNF AQVWCGTYRP EYAVNSIKTD VHSPGNFRII 720
  721 GTLQNSAEFS EAFHCRKNSY MNPEKKCRVW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..750] PSI-BLAST 1000.0 Neutral endopeptidase (neprilysin)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  5.33358263548929 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.99457783001146 bayes_pls_golite062009
  • bradykinin receptor binding
    		•  4.68498310889748 bayes_pls_golite062009
  • endopeptidase activity
    		•  4.16532996235931 bayes_pls_golite062009
  • metallopeptidase activity
    		•  3.94798058866011 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  3.43236442601127 bayes_pls_golite062009
  • peptidyl-dipeptidase activity
    		•  3.15882456934259 bayes_pls_golite062009
  • hydrolase activity
    		•  2.61181165622708 bayes_pls_golite062009
  • angiotensin receptor activity
    		•  2.47329778652768 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  2.40931483220122 bayes_pls_golite062009
  • exopeptidase activity
    		•  2.07461908743946 bayes_pls_golite062009
  • receptor binding
    		•  2.07222569254168 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.71636138555452 bayes_pls_golite062009
  • receptor activity
    		•  1.71573921458029 bayes_pls_golite062009
  • peptide binding
    		•  1.58227634414618 bayes_pls_golite062009
  • protein binding
    		•  1.58118182554863 bayes_pls_golite062009
  • binding
    		•  1.55761777216628 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.42071856700201 bayes_pls_golite062009
  • signal transducer activity
    		•  1.42071856700201 bayes_pls_golite062009
  • viral receptor activity
    		•  1.39617252453036 bayes_pls_golite062009
  • epoxide hydrolase activity
    		•  1.37998417474643 bayes_pls_golite062009
  • ether hydrolase activity
    		•  1.18753073809881 bayes_pls_golite062009
  • protein complex binding
    		•  1.16270782056592 bayes_pls_golite062009
  • integrin binding
    		•  0.93449223670512 bayes_pls_golite062009
  • catalytic activity
    		•  0.891187593353827 bayes_pls_golite062009
  • interleukin-6 receptor binding
    		•  0.711782218042781 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.61233964043845 bayes_pls_golite062009
  • peptide receptor activity, G-protein coupled
    		•  0.597899738932066 bayes_pls_golite062009
  • peptide receptor activity
    		•  0.574641388356132 bayes_pls_golite062009
  • zinc ion binding
    		•  0.49304764842799 bayes_pls_golite062009
  • hydrolase activity, acting on ether bonds
    		•  0.457157426475929 bayes_pls_golite062009
  • serine hydrolase activity
    		•  0.393080846858665 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  0.374597710524442 bayes_pls_golite062009
  • growth factor activity
    		•  0.259654587796416 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  0.252655558968584 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.21808506596674 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.21514043665594 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle