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Protein Overview: clp-1

General Information:
Name(s) found: clp-1 / CE37744 [WormBase]
Description(s) found:
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  • WBGene00000542 locus:clp-1 Calpain clp-1 status:Confirmed UniProt:P34308 protein_id:CCD63433.1 [WormBase]
  • gi|71981307|ref|NP_498740.2| CaLPain family member (clp-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|55710081|gb|AAV58888.1| Calpain family protein 1, isoform b [Caenorhabditis elegans] [NCBI NR]
  • CE37744 WBGene00000542 locus:clp-1 status:Confirmed SW:P34308 protein_id:AAV58888.1 [wormpep150.fasta]
  • 37744 WBGene00000542 locus:clp-1 status:Confirmed SW:P34308 protein_id:AAV58888.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • CE37744 WBGene00000542 locus:clp-1 status:Confirmed protein_id:AAV58888.1 [WormBase_C-elegans_na_01-20-2005_combined_reversed.fasta]
  • CE37744 WBGene00000542 locus:clp-1 status:Confirmed UniProt:P34308 protein_id:AAV58888.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE37744 WBGene00000542 locus:clp-1 status:Confirmed UniProt:P34308 protein_id:AAV58888.1| [wormORF-contam.fasta]
  • Calpain family protein 1, isoform b [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CaLPain family member (clp-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE37744 WBGene00000542 locus:clp-1 status:Confirmed UniProt:P34308 protein_id:CCD63433.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE37744 WBGene00000542 locus:clp-1 status:Confirmed UniProt:P34308 protein_id:CCD63433.1 Calpain clp-1 [wormpep246-ecoli-contam.fasta]
  • Isoform of P34308, Isoform b of Calpain clp-1 OS=Caenorhabditis elegans GN=clp-1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 737 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IEALink to PubMed article]
    intracellular [IEALink to PubMed article]
    Biological Process: cell death [IMPLink to PubMed article]
    proteolysis [IEALink to PubMed article]
    Molecular Function: cysteine-type endopeptidase activity [IEALink to PubMed article]
    calcium-dependent cysteine-type endopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADDEEEIIQ KVEVKPDEFN GLIGSIAGNL IRDKVGGAGG DILGGLASNF FGGGGGGGGG  60
   61 GGGGGFGGGN GGFGGGGGGN YGGGGGNQGG GGGGGFNFND IGGLINSMGG GGGGGQRQGG 120
  121 GGGGFGDILG GIGSLIGGGG GGQYNGGGGN VNPNNLNGGM VNVIGNLIGE AAHRFLGVDP 180
  181 GTGRIIGAVA GNVIMGLGGK DNSLGNIGKV ILDNIISGKF RRDVDPFVRP GPDPDRGGGG 240
  241 SGPSPISPRP TTEPQDFYEL RDQCLESKRL FEDPQFLAND SSLFFSKRPP KRVEWLRPGE 300
  301 ITREPQLITE GHSRFDVIQG ELGDCWLLAA AANLTLKDEL FYRVVPPDQS FTENYAGIFH 360
  361 FQFWQYGKWV DVVIDDRLPT SNGELLYMHS ASNNEFWSAL LEKAYAKLFG SYEALKGGTT 420
  421 SEALEDMTGG LTEFIDLKNP PRNLMQMMMR GFEMGSLFGC SIEADPNVWE AKMSNGLVKG 480
  481 HAYSITGCRI VDGPNGQTCI LRIRNPWGNE QEWNGPWSDN SREWRSVPDS VKQDMGLKFD 540
  541 HDGEFWMSFD DFMRNFEKME ICNLGPDVMD EVYQMTGVKA AGMVWAANTH DGAWVRNQTA 600
  601 GGCRNYINTF ANNPQFRVQL TDSDPDDDDE LCTVIFAVLQ KYRRNLKQDG LDNVPIGFAV 660
  661 YDMNNAGNNR GRLSKQFFAA NKSAMRSAAF INLREMTGRF RVPPGNYVVV PSTFEPNEEA 720
  721 EFMLRVYTNG FIESEEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..219] PSI-BLAST 22.522879 Metalloprotease
    2 View Details [220..737] PSI-BLAST 172.0 Calpain large subunit, C-terminal domain (domain IV); Calpain large subunit, middle domain (domain III); Calpain large subunit, catalytic domain (domain II)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.19059336788201 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  3.05412701733177 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.93596559605971 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.91734319991078 bayes_pls_golite062009
  • hydrolase activity
    		•  2.43328552376748 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • protein binding
    		•  1.92445772322782 bayes_pls_golite062009
  • binding
    		•  1.92046698500094 bayes_pls_golite062009
  • transporter activity
    		•  1.21845572420504 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.19670958990587 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.07520173658976 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.00091316610003 bayes_pls_golite062009
  • signal transducer activity
    		•  0.9347662946007 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.9347662946007 bayes_pls_golite062009
  • calcium ion binding
    		•  0.687204894708051 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  0.495368836247989 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.484449686814032 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.354062437867002 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.313326619937245 bayes_pls_golite062009
  • DNA binding
    		•  0.306964954191276 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.246369226539662 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.193338880082314 bayes_pls_golite062009
  • tubulin binding
    		•  0.11107511867058 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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