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View Structure Prediction Details

Protein: clp-1
Organism: Caenorhabditis elegans
Length: 737 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for clp-1.

Description E-value Query
Range
Subject
Range
gi|49900979 - gi|49900979|gb|AAH75862.1| CAPN1 protein [Homo sapiens]
611.0 [0..245] [737..30]

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Predicted Domain #1
Region A:
Residues: [1-219]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADDEEEIIQ KVEVKPDEFN GLIGSIAGNL IRDKVGGAGG DILGGLASNF FGGGGGGGGG  60
   61 GGGGGFGGGN GGFGGGGGGN YGGGGGNQGG GGGGGFNFND IGGLINSMGG GGGGGQRQGG 120
  121 GGGGFGDILG GIGSLIGGGG GGQYNGGGGN VNPNNLNGGM VNVIGNLIGE AAHRFLGVDP 180
  181 GTGRIIGAVA GNVIMGLGGK DNSLGNIGKV ILDNIISGK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.522879
Match: 1h71P
Description: Metalloprotease
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [220-737]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FRRDVDPFVR PGPDPDRGGG GSGPSPISPR PTTEPQDFYE LRDQCLESKR LFEDPQFLAN  60
   61 DSSLFFSKRP PKRVEWLRPG EITREPQLIT EGHSRFDVIQ GELGDCWLLA AAANLTLKDE 120
  121 LFYRVVPPDQ SFTENYAGIF HFQFWQYGKW VDVVIDDRLP TSNGELLYMH SASNNEFWSA 180
  181 LLEKAYAKLF GSYEALKGGT TSEALEDMTG GLTEFIDLKN PPRNLMQMMM RGFEMGSLFG 240
  241 CSIEADPNVW EAKMSNGLVK GHAYSITGCR IVDGPNGQTC ILRIRNPWGN EQEWNGPWSD 300
  301 NSREWRSVPD SVKQDMGLKF DHDGEFWMSF DDFMRNFEKM EICNLGPDVM DEVYQMTGVK 360
  361 AAGMVWAANT HDGAWVRNQT AGGCRNYINT FANNPQFRVQ LTDSDPDDDD ELCTVIFAVL 420
  421 QKYRRNLKQD GLDNVPIGFA VYDMNNAGNN RGRLSKQFFA ANKSAMRSAA FINLREMTGR 480
  481 FRVPPGNYVV VPSTFEPNEE AEFMLRVYTN GFIESEEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 172.0
Match: 1kfuL
Description: Calpain large subunit, C-terminal domain (domain IV); Calpain large subunit, middle domain (domain III); Calpain large subunit, catalytic domain (domain II)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.19059336788201 bayes_pls_golite062009
cysteine-type peptidase activity 3.05412701733177 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.93596559605971 bayes_pls_golite062009
endopeptidase activity 2.91734319991078 bayes_pls_golite062009
hydrolase activity 2.43328552376748 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
protein binding 1.92445772322782 bayes_pls_golite062009
binding 1.92046698500094 bayes_pls_golite062009
transporter activity 1.21845572420504 bayes_pls_golite062009
cytoskeletal protein binding 1.19670958990587 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.07520173658976 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
transmembrane transporter activity 1.00091316610003 bayes_pls_golite062009
signal transducer activity 0.9347662946007 bayes_pls_golite062009
molecular transducer activity 0.9347662946007 bayes_pls_golite062009
calcium ion binding 0.687204894708051 bayes_pls_golite062009
ubiquitin-specific protease activity 0.495368836247989 bayes_pls_golite062009
substrate-specific transporter activity 0.484449686814032 bayes_pls_golite062009
transcription regulator activity 0.354062437867002 bayes_pls_golite062009
nucleic acid binding 0.313326619937245 bayes_pls_golite062009
DNA binding 0.306964954191276 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.246369226539662 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
active transmembrane transporter activity 0.193338880082314 bayes_pls_golite062009
tubulin binding 0.11107511867058 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle