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Protein Overview: PRP22_YEAST

General Information:
Name(s) found: PRP22_YEAST [Swiss-Prot]
Description(s) found:
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  • Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRP22 PE=1 SV=1 [Swiss-Prot]
  • DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes [Saccharomyces cerevisiae] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 1145 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDISKLIGA IVGSDDPVII EFVLNIINKS GNLQEFIRNI QKLDAGISYE DSIKMYNAFL  60
   61 GKQEEEKVRN KVKSSPLSQK INQVLKDDVN LDDPVVTEFV LSILNKSKSI TEFQEQLNLM 120
  121 QSGLDNETIF KIYQIASPPV MKEEVSVLPS TKIPAKIEAK IEEEVQKIES LDPSPVLHKV 180
  181 YEGKVRNITT FGCFVQIFGT RMKNCDGLVH ISEMSDQRTL DPHDVVRQGQ HIFVEVIKIQ 240
  241 NNGKISLSMK NIDQHSGEIR KRNTESVEDR GRSNDAHTSR NMKNKIKRRA LTSPERWEIR 300
  301 QLIASGAASI DDYPELKDEI PINTSYLTAK RDDGSIVNGN TEKVDSKLEE QQRDETDEID 360
  361 VELNTDDGPK FLKDQQVKGA KKYEMPKITK VPRGFMNRSA INGSNAIRDH REEKLRKKRE 420
  421 IEQQIRKQQS FDDPTKNKKD SRNEIQMLKN QLIVTEWEKN RMNESISYGK RTSLPISAQR 480
  481 QTLPVYAMRS ELIQAVRDNQ FLVIVGETGS GKTTQITQYL DEEGFSNYGM IGCTQPRRVA 540
  541 AVSVAKRVAE EVGCKVGHDV GYTIRFEDVT GPDTRIKYMT DGMLQREALL DPEMSKYSVI 600
  601 MLDEAHERTV ATDVLFALLK KAAIKRPELK VIVTSATLNS AKFSEYFLNC PIINIPGKTF 660
  661 PVEVLYSQTP QMDYIEAALD CVIDIHINEG PGDILVFLTG QEEIDSCCEI LYDRVKTLGD 720
  721 SIGELLILPV YSALPSEIQS KIFEPTPKGS RKVVFATNIA ETSITIDGIY YVVDPGFAKI 780
  781 NIYNARAGIE QLIVSPISQA QANQRKGRAG RTGPGKCYRL YTESAFYNEM LENTVPEIQR 840
  841 QNLSHTILML KAMGINDLLK FDFMDPPPKN LMLNALTELY HLQSLDDEGK LTNLGKEMSL 900
  901 FPMDPTLSRS LLSSVDNQCS DEIVTIISML SVQNVFYRPK DRQLEADSKK AKFHHPYGDH 960
  961 LTLLNVYTRW QQANYSEQYC KTNFLHFRHL KRARDVKSQI SMIFKKIGLK LISCHSDPDL1020
 1021 IRKTFVSGFF MNAAKRDSQV GYKTINGGTE VGIHPSSSLY GKEYEYVMYH SIVLTSREYM1080
 1081 SQVTSIEPQW LLEVAPHFYK AGDAESQSRK KAKIIPLHNK FAKDQNSWRL SSIRQSRERA1140
 1141 LGIKR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..122] MSA 3.158997 View MSA. No confident structure predictions are available.
    2 View Details [123..282] PSI-BLAST 98.144602 S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase
    3 View Details [283..432] MSA 4.179995 View MSA. No confident structure predictions are available.
    4 View Details [433..661] PSI-BLAST 9.154902 RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
    5 View Details [662..833] PSI-BLAST 9.154902 RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
    6 View Details [834..1145] MSA 12.325996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
    		• 4.75811129307632 bayes_pls_golite062009
  • transcription termination factor activity
    		•  4.27506184839126 bayes_pls_golite062009
  • RNA binding
    		•  4.05373509885278 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  3.73145378633995 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.24341202600661 bayes_pls_golite062009
  • structural molecule activity
    		•  3.16728233432927 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.81524862921454 bayes_pls_golite062009
  • binding
    		•  1.7774714353448 bayes_pls_golite062009
  • mRNA binding
    		•  1.6485756688073 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.62996999055328 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.45130233071198 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  1.35850109411274 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  1.35845277283398 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  1.35845277283398 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.19236946227657 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.15212468568198 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.10445667068538 bayes_pls_golite062009
  • DNA binding
    		•  1.01454217691792 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.83268201349295 bayes_pls_golite062009
  • second spliceosomal transesterification activity
    		•  0.448378021030889 bayes_pls_golite062009
  • protein binding
    		•  0.423986689445573 bayes_pls_golite062009
  • ligase activity
    		•  0.346041081217685 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.32084431704638 bayes_pls_golite062009
  • transcription factor activity
    		•  0.298729064067577 bayes_pls_golite062009
  • translation regulator activity
    		•  0.22908707234671 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.179682348023561 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.151650064901878 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.11625379846973 bayes_pls_golite062009
  • catalytic activity
    		•  0.10089766806364 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
    		• 4.704140727858 bayes_pls_golite062009
  • binding
    		•  2.44689197844883 bayes_pls_golite062009
  • RNA binding
    		•  2.29590582680214 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.57653963868443 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.42791449104435 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.41477043612798 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.39335733374328 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.36724390116598 bayes_pls_golite062009
  • DNA binding
    		•  1.11699929651302 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.989226939888218 bayes_pls_golite062009
  • mRNA binding
    		•  0.76699944561918 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.652333406433794 bayes_pls_golite062009
  • helicase activity
    		•  0.6191010101321 bayes_pls_golite062009
  • motor activity
    		•  0.61636596887462 bayes_pls_golite062009
  • structural molecule activity
    		•  0.596382945962261 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.461763181659193 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.458831409927227 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.455976987338331 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.422944846459286 bayes_pls_golite062009
  • snRNA binding
    		•  0.418985924846052 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • translation release factor activity
    		•  0.178286731022211 bayes_pls_golite062009
  • translation termination factor activity
    		•  0.151456842619444 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0434163635422169 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0272673919333979 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle