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Protein Overview: gi|22651765, gi|...

General Information:
Name(s) found: gi|77020289 [NCBI NR]
gi|22651765 [NCBI NR]
Description(s) found:
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  • gi|77020289|ref|NP_058699.2| v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog [Rattus norvegicus] [NCBI NR]
  • gi|22651765|gb|AAM50093.1| neu protooncoprotein [Rattus norvegicus] [NCBI NR]
  • neu protooncoprotein [Rattus norvegicus] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Tax_Id=10116 Neu protooncoprotein [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta]
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 NEU PROTOONCOPROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog [rat-ipi-250309-contam.fasta]
  • receptor tyrosine-protein kinase erbB-2 [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Neu protooncoprotein OS=Rattus norvegicus GN=Erbb2 [011711_HMR.fasta]
  • Neu protooncoprotein OS=Rattus norvegicus GN=Erbb2 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
  • Isoform of P06494, Neu protooncoprotein OS=Rattus norvegicus GN=Erbb2 PE=1 SV=1 [RAT.fasta.20160308]
    • Organism: Rattus norvegicus
    Length: 1259 amino acids

    Gene Ontology:
    Cellular Component: lateral loop [IDA]
    nucleus [IDA]
    basal plasma membrane [IDA]
    perinuclear region of cytoplasm [IDA]
    cytoplasm [UNKNOWN][IEA]
    microvillus [IDA]
    postsynaptic membrane [IDA]
    membrane raft [IDA]
    integral to membrane [IEA]
    receptor complex [UNKNOWN][IEA]
    basolateral plasma membrane [UNKNOWN][IDA]
    apical plasma membrane [UNKNOWN][IDA]
    Biological Process: positive regulation of MAP kinase activity [UNKNOWN][IEA]
    peptidyl-tyrosine phosphorylation [IEA]
    positive regulation of phosphoinositide 3-kinase cascade [IMP]
    motor axon guidance [UNKNOWN][IEA]
    phosphoinositide 3-kinase cascade [UNKNOWN]
    negative regulation of immature T cell proliferation in the thymus [UNKNOWN][IEA]
    positive regulation of cell proliferation [IMP]
    response to progesterone stimulus [IEP]
    nervous system development [UNKNOWN]
    positive regulation of Ras protein signal transduction [IMP]
    protein amino acid autophosphorylation [UNKNOWN][IDA]
    myelination [UNKNOWN][IEA]
    response to axon injury [IDA]
    tongue development [IEP]
    positive regulation of cell adhesion [UNKNOWN][IEA]
    estrus [IMP]
    neuromuscular junction development [UNKNOWN][IEA]
    sympathetic nervous system development [IMP]
    heart development [UNKNOWN][IEA]
    wound healing [UNKNOWN][IEA]
    regulation of cell differentiation [TAS]
    liver development [IEP]
    positive regulation of epithelial cell proliferation [UNKNOWN][IEA]
    mammary gland involution [IEP]
    signal transduction [UNKNOWN]
    transmembrane receptor protein tyrosine kinase signaling pathway [UNKNOWN][IEA]
    peripheral nervous system development [UNKNOWN][IMP]
    cell surface receptor linked signaling pathway [UNKNOWN]
    positive regulation of MAPKKK cascade [IMP]
    regulation of cell proliferation [TAS]
    central nervous system development [TAS]
    skeletal muscle tissue development [IEP]
    response to drug [IEP]
    negative regulation of apoptosis [IMP]
    glial cell differentiation [IGI]
    Molecular Function: growth factor binding [UNKNOWN][IEA]
    identical protein binding [UNKNOWN][IEA]
    protein phosphatase binding [UNKNOWN][IEA]
    protein C-terminus binding [UNKNOWN][IEA]
    receptor activity [IEA]
    nucleotide binding [IEA]
    ATP binding [IEA]
    protein tyrosine kinase activity [UNKNOWN][IDA]
    transmembrane receptor activity [UNKNOWN][IEA]
    protein binding [UNKNOWN][IPI]
    ubiquitin protein ligase binding [IPI]
    transmembrane receptor protein tyrosine kinase activity [UNKNOWN][IEA]
    protein heterodimerization activity [UNKNOWN][IPI]
    receptor signaling protein tyrosine kinase activity [IEA]
    glycoprotein binding [IPI]
    Hsp90 protein binding [IPI]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIIMELAAWC RWGFLLALLP PGIAGTQVCT GTDMKLRLPA SPETHLDMLR HLYQGCQVVQ  60
   61 GNLELTYVPA NASLSFLQDI QEVQGYMLIA HNQVKRVPLQ RLRIVRGTQL FEDKYALAVL 120
  121 DNRDPQDNVA ASTPGRTPEG LRELQLRSLT EILKGGVLIR GNPQLCYQDM VLWKDVFRKN 180
  181 NQLAPVDIDT NRSRACPPCA PACKDNHCWG ESPEDCQILT GTICTSGCAR CKGRLPTDCC 240
  241 HEQCAAGCTG PKHSDCLACL HFNHSGICEL HCPALVTYNT DTFESMHNPE GRYTFGASCV 300
  301 TTCPYNYLST EVGSCTLVCP PNNQEVTAED GTQRCEKCSK PCARVCYGLG MEHLRGARAI 360
  361 TSDNVQEFDG CKKIFGSLAF LPESFDGDPS SGIAPLRPEQ LQVFETLEEI TGYLYISAWP 420
  421 DSLRDLSVFQ NLRIIRGRIL HDGAYSLTLQ GLGIHSLGLR SLRELGSGLA LIHRNAHLCF 480
  481 VHTVPWDQLF RNPHQALLHS GNRPEEDCGL EGLVCNSLCA HGHCWGPGPT QCVNCSHFLR 540
  541 GQECVEECRV WKGLPREYVS DKRCLPCHPE CQPQNSSETC FGSEADQCAA CAHYKDSSSC 600
  601 VARCPSGVKP DLSYMPIWKY PDEEGICQPC PINCTHSCVD LDERGCPAEQ RASPVTFIIA 660
  661 TVVGVLLFLI LVVVVGILIK RRRQKIRKYT MRRLLQETEL VEPLTPSGAM PNQAQMRILK 720
  721 ETELRKVKVL GSGAFGTVYK GIWIPDGENV KIPVAIKVLR ENTSPKANKE ILDEAYVMAG 780
  781 VGSPYVSRLL GICLTSTVQL VTQLMPYGCL LDHVREHRGR LGSQDLLNWC VQIAKGMSYL 840
  841 EDVRLVHRDL AARNVLVKSP NHVKITDFGL ARLLDIDETE YHADGGKVPI KWMALESILR 900
  901 RRFTHQSDVW SYGVTVWELM TFGAKPYDGI PAREIPDLLE KGERLPQPPI CTIDVYMIMV 960
  961 KCWMIDSECR PRFRELVSEF SRMARDPQRF VVIQNEDLGP SSPMDSTFYR SLLEDDDMGD1020
 1021 LVDAEEYLVP QQGFFSPDPT PGTGSTAHRR HRSSSTRSGG GELTLGLEPS EEGPPRSPLA1080
 1081 PSEGAGSDVF DGDLAMGVTK GLQSLSPHDL SPLQRYSEDP TLPLPPETDG YVAPLACSPQ1140
 1141 PEYVNQSEVQ PQPPLTPEGP LPPVRPAGAT LERPKTLSPG KNGVVKDVFA FGGAVENPEY1200
 1201 LVPREGTASP PHPSPAFSPA FDNLYYWDQN SSEQGPPPSN FEGTPTAENP EYLGLDVPV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle