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Protein Overview: gi|52696121, gi|...

General Information:
Name(s) found: gi|52696121 [NCBI NR]
gi|241913472 [NCBI NR]
gi|227343844 [NCBI NR]
gi|227343843 [NCBI NR]
Description(s) found:
Found 5 descriptions.
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  • gi|52696121|pdb|1VJY|A Chain A, Crystal Structure Of A Naphthyridine Inhibitor Of Human Tgf- Beta Type I Receptor [NCBI NR]
  • gi|241913472|pdb|3HMM|A Chain A, Structure Of Alk5 + Gw855857 [NCBI NR]
  • gi|227343844|pdb|3GXL|A Chain A, Alk-5 Kinase Complex With Gw857175 [NCBI NR]
  • gi|227343843|pdb|3GXJ|A Chain A, Structure Of Alk5 + Gw855857 [NCBI NR]
    • Organism: Homo sapiens
    Length: 303 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER SWFREAEIYQ TVMLRHENIL  60
   61 GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE GMIKLALSTA SGLAHLHMEI 120
  121 VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA DLGLAVRHDS ATDTIDIAPN HRVGTKRYMA 180
  181 PEVLDDSINM KHFESFKRAD IYAMGLVFWE IARRCSIGGI HEDYQLPYYD LVPSDPSVEE 240
  241 MRKVVCEQKL RPNIPNRWQS CEALRVMAKI MRECWYANGA ARLTALRIKK TLSQLSQQEG 300
  301 IKM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Noble WS, et al. (2009) Manuscript in preparation. gi|112491310 gi|13786858 gi|219109210, gi... gi|52696121, gi|... gi|56554577

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..303] PSI-BLAST 64.0 Type I TGF-beta receptor R4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • activin receptor activity
    		•  9.43409082112081 bayes_pls_golite062009
  • activin binding
    		•  7.11944534332244 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  6.41728494915949 bayes_pls_golite062009
  • activin receptor activity, type I
    		•  6.1393596497059 bayes_pls_golite062009
  • protein kinase activity
    		•  5.63683237027974 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  3.37600307408153 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  3.37600307408153 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.1965684217331 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.97315540587667 bayes_pls_golite062009
  • receptor activity
    		•  2.96273889901429 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • signal transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • growth factor binding
    		•  2.61235080252818 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  2.57601476622612 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • follistatin binding
    		•  2.2292685945544 bayes_pls_golite062009
  • binding
    		•  2.10874590528357 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  2.00819948109978 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • insulin receptor activity
    		•  1.91768456749814 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.82118598657067 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  1.46877913443522 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.30850950497296 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • insulin binding
    		•  1.03564126441771 bayes_pls_golite062009
  • SMAD binding
    		•  1.02108562119195 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • amine binding
    		•  0.783881819862438 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.58590430118616 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.57617745233877 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type II
    		•  0.365530951355731 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.34434685718027 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.312169974523858 bayes_pls_golite062009
  • kinase binding
    		•  0.26752427107238 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • PTB domain binding
    		•  0.216691319543711 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.213371031328104 bayes_pls_golite062009
  • cytokine binding
    		•  0.17817111033393 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.150740450460731 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  0.0123645889643007 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00674998152095019 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
  • SH2 domain binding
    		•  2.96656737540424E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle