| Protein: | daf-1 |
| Organism: | Caenorhabditis elegans |
| Length: | 668 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
|
Region A: Residues: [1-200] |
1 11 21 31 41 51
| | | | | |
1 MRIRHVVFCL LALVYGAETS DDDLDERTNI FIRDKLIPAL KLAEVTKVNF TRLHLCHCSR 60
61 EVGCNARTTG WVPGIEFLNE TDRSFYENTC YTDGSCYQSA RPSPEISHFG CMDEKSVTDE 120
121 TEFHDTAAKV CTNNTKDPHA TVWICCDKGN FCANETIIHL APGPQQSSTW LILTILALLT 180
181 FIVLLGIAIF LTRKSWEAKF
|
| Detection Method: |  |
| Confidence: | 13.0 |
| Match: | 1rewC |
| Description: | Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| transforming growth factor beta binding | 2.91714500246524 | bayes_pls_golite062009 |
| receptor activity | 2.74055213309696 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 2.63843756028069 | bayes_pls_golite062009 |
| signal transducer activity | 2.51859905018984 | bayes_pls_golite062009 |
| molecular transducer activity | 2.51859905018984 | bayes_pls_golite062009 |
| binding | 2.42849959483419 | bayes_pls_golite062009 |
| protein binding | 2.27773193148456 | bayes_pls_golite062009 |
| growth factor binding | 2.11370016324137 | bayes_pls_golite062009 |
| SMAD binding | 2.11166655078306 | bayes_pls_golite062009 |
| U-plasminogen activator receptor activity | 1.87257816307638 | bayes_pls_golite062009 |
| type I transforming growth factor beta receptor binding | 1.8615627852658 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 1.31043490228373 | bayes_pls_golite062009 |
| cytokine binding | 1.30600639196836 | bayes_pls_golite062009 |
| receptor binding | 0.899783960746717 | bayes_pls_golite062009 |
| transforming growth factor beta receptor binding | 0.897552923016526 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase binding | 0.897552923016526 | bayes_pls_golite062009 |
| polysaccharide binding | 0.461857396098789 | bayes_pls_golite062009 |
| receptor signaling protein activity | 0.227519165953748 | bayes_pls_golite062009 |
| pattern binding | 0.21003196804615 | bayes_pls_golite062009 |
|
Region A: Residues: [201-265] |
1 11 21 31 41 51
| | | | | |
1 DWYIRFKPKP GDPLRETENN VPMVTMGDGA GSSVPEVAPI EQQGSTMSTS AGNSFPPGIM 60
61 PNNMK
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [266-668] |
1 11 21 31 41 51
| | | | | |
1 DMLDVLEETS GSGMGPTTLH KLTIGGQIRL TGRVGSGRFG NVSRGDYRGE AVAVKVFNAL 60
61 DEPAFHKETE IFETRMLRHP NVLRYIGSDR VDTGFVTELW LVTEYHPSGS LHDFLLENTV 120
121 NIETYYNLMR STASGLAFLH NQIGGSKESN KPAMAHRDIK SKNIMVKNDL TCAIGDLGLS 180
181 LSKPEDAASD IIANENYKCG TRYLAPEILN STMQFTVFES YQCADVYSFS LVMWETLCRC 240
241 EDGDVLPREA ATVIPYIEWT DRDPQDAQMF DVVCTRRLRP TENPLWKDHP EMKHIMEIIK 300
301 TCWNGNPSAR FTSYICRKRM DERQQLLLDK KAKAVAQTAG VTVQDRKILG PQKPKDESPA 360
361 NGAPRIVQKE IDREDEQENW RETAKTPNGH ISSNDDSSRP LLG
|
| Detection Method: | |
| Confidence: | 66.221849 |
| Match: | 1b6cB |
| Description: | Type I TGF-beta receptor R4 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| activin receptor activity | 9.43409082112081 | bayes_pls_golite062009 |
| activin binding | 7.11944534332244 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 6.41728494915949 | bayes_pls_golite062009 |
| activin receptor activity, type I | 6.1393596497059 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 5.49988294224815 | bayes_pls_golite062009 |
| protein kinase activity | 5.4586557943719 | bayes_pls_golite062009 |
| kinase activity | 5.3287080791198 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.96052051118534 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| transferase activity | 3.97138602499442 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 3.40140621607334 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 3.37600307408153 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 3.37600307408153 | bayes_pls_golite062009 |
| transmembrane receptor activity | 3.1965684217331 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 2.97315540587667 | bayes_pls_golite062009 |
| receptor activity | 2.96273889901429 | bayes_pls_golite062009 |
| molecular transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| signal transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 2.8153155526437 | bayes_pls_golite062009 |
| binding | 2.74863538127007 | bayes_pls_golite062009 |
| growth factor binding | 2.61235080252818 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type I | 2.57601476622612 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| follistatin binding | 2.2292685945544 | bayes_pls_golite062009 |
| receptor signaling protein activity | 2.10379226653669 | bayes_pls_golite062009 |
| fibroblast growth factor binding | 2.00819948109978 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| insulin receptor activity | 1.91768456749814 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| fibroblast growth factor 1 binding | 1.82118598657067 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| transcription regulator activity | 1.56748951434625 | bayes_pls_golite062009 |
| transforming growth factor beta binding | 1.46877913443522 | bayes_pls_golite062009 |
| nucleic acid binding | 1.46547714006072 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 1.42275431028856 | bayes_pls_golite062009 |
| DNA binding | 1.35333135345112 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 1.30850950497296 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| PTB domain binding | 1.14009984975509 | bayes_pls_golite062009 |
| transporter activity | 1.11833481501707 | bayes_pls_golite062009 |
| transcription factor activity | 1.10928254946881 | bayes_pls_golite062009 |
| insulin binding | 1.03564126441771 | bayes_pls_golite062009 |
| SMAD binding | 1.02108562119195 | bayes_pls_golite062009 |
| transcription activator activity | 0.997272622653026 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.97575992765505 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| amine binding | 0.783881819862438 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.705905455086486 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 0.57617745233877 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 0.499492353295369 | bayes_pls_golite062009 |
| protein serine/threonine/tyrosine kinase activity | 0.48345772948903 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.450699332958421 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.401250804041384 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| MAP kinase kinase kinase activity | 0.37115026509016 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type II | 0.365530951355731 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 0.34434685718027 | bayes_pls_golite062009 |
| peptide hormone binding | 0.312169974523858 | bayes_pls_golite062009 |
| kinase binding | 0.26752427107238 | bayes_pls_golite062009 |
| protein complex binding | 0.239339759110451 | bayes_pls_golite062009 |
| cytokine binding | 0.17817111033393 | bayes_pls_golite062009 |
| cell adhesion molecule binding | 0.150740450460731 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 0.148194101970458 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 0.0123645889643007 | bayes_pls_golite062009 |
| protein kinase binding | 0.00674998152095019 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0040394359628233 | bayes_pls_golite062009 |
| SH2 domain binding | 2.96656737540424E-4 | bayes_pls_golite062009 |
