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View Structure Prediction Details

Protein: fkb-8
Organism: Caenorhabditis elegans
Length: 290 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for fkb-8.

Description E-value Query
Range
Subject
Range
gi|7509456, gi|1... - gi|7509456|pir||T26538 hypothetical protein Y18D10A.19b - Caenorhabditis elegans, ref|NP_493256.1| F...
247.0 [0..1] [290..1]

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Predicted Domain #1
Region A:
Residues: [1-290]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKDQNGVAST DDSVLPSWSN PDVGQFIVST YNEYEYKRIP FRELEFGCLL CRMRTFNHEG  60
   61 MKKHLRDHVV HKKSSCEHEK PGKTGIHHQV DKAGNGVMPE NGQLVQCYIE IKLADCYTSW 120
  121 SNYESQNPII FKIGFGEVIP GLDIGIPKMK VGEIATFHVS GKYGYGRAGF RGLIPRNASL 180
  181 TCKVRLFNCS WDSYAKIGVD RQILVQGDNV TKSKNGQTVT CHYVLILVDG TKIDSSRDRE 240
  241 TPFKFKIGKG EVIKGWDQGV AQMSVKEKSK LTIAPAFGFE KGKLPAGIPA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.0
Match: 1kt0A
Description: FKBP51, C-terminal domain; FKBP51, N-terminal domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ryanodine-sensitive calcium-release channel activity 10.9968443145942 bayes_pls_golite062009
intracellular ligand-gated calcium channel activity 10.9968443145942 bayes_pls_golite062009
macrolide binding 7.31599503004442 bayes_pls_golite062009
FK506 binding 7.22442625476031 bayes_pls_golite062009
metal ion transmembrane transporter activity 6.74926751944787 bayes_pls_golite062009
calcium channel activity 6.4374377859142 bayes_pls_golite062009
cation channel activity 6.06732269872248 bayes_pls_golite062009
ion channel activity 5.45007096522107 bayes_pls_golite062009
passive transmembrane transporter activity 5.32426176964634 bayes_pls_golite062009
channel activity 5.32426176964634 bayes_pls_golite062009
substrate-specific channel activity 5.28960420749143 bayes_pls_golite062009
gated channel activity 5.28074654906904 bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity 4.0615867467963 bayes_pls_golite062009
cis-trans isomerase activity 3.99265212272703 bayes_pls_golite062009
ligand-gated channel activity 3.34717828007833 bayes_pls_golite062009
ligand-gated ion channel activity 3.34717828007833 bayes_pls_golite062009
ion transmembrane transporter activity 2.6566793500337 bayes_pls_golite062009
cation transmembrane transporter activity 2.61794461605199 bayes_pls_golite062009
calcium-release channel activity 2.58969194870156 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.47257819150887 bayes_pls_golite062009
isomerase activity 2.31710030777753 bayes_pls_golite062009
transcription regulator activity 1.85589011277711 bayes_pls_golite062009
receptor activity 1.78361575899771 bayes_pls_golite062009
transmembrane receptor activity 1.7459556028988 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.68688812199737 bayes_pls_golite062009
kinase activity 1.67904764195462 bayes_pls_golite062009
binding 1.63170667962375 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.57898291235576 bayes_pls_golite062009
signal transducer activity 1.53711974553033 bayes_pls_golite062009
molecular transducer activity 1.53711974553033 bayes_pls_golite062009
protein kinase activity 1.45320632553313 bayes_pls_golite062009
drug binding 1.39643621593407 bayes_pls_golite062009
transferase activity 1.34122735969662 bayes_pls_golite062009
receptor serine/threonine kinase binding 1.32709321745178 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 1.32470025150272 bayes_pls_golite062009
transforming growth factor beta receptor binding 1.32470025150272 bayes_pls_golite062009
transporter activity 1.25197125648774 bayes_pls_golite062009
protein binding 1.08765413491791 bayes_pls_golite062009
SMAD binding 1.04905381164355 bayes_pls_golite062009
transmembrane transporter activity 1.03909235910355 bayes_pls_golite062009
catalytic activity 0.885282592863018 bayes_pls_golite062009
substrate-specific transporter activity 0.789390402522536 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.780499202755666 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.763739321802433 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.763739321802433 bayes_pls_golite062009
intracellular ligand-gated ion channel activity 0.727019445105701 bayes_pls_golite062009
protein serine/threonine kinase activity 0.671059013500415 bayes_pls_golite062009
activin binding 0.33489895389042 bayes_pls_golite062009
unfolded protein binding 0.27473817613726 bayes_pls_golite062009
histone binding 0.221748741603068 bayes_pls_golite062009
transcription elongation regulator activity 0.21145105012677 bayes_pls_golite062009

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