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View Structure Prediction Details

Protein: cyp-33C12
Organism: Caenorhabditis elegans
Length: 426 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cyp-33C12.

Description E-value Query
Range
Subject
Range
gi|66731521 - gi|66731521|gb|AAY51973.1| cytochrome P450 2C8 [Cercopithecus aethiops]
345.0 [0..1] [425..5]

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Predicted Domain #1
Region A:
Residues: [1-426]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLLLFLSVL FLALFYEFHW KRRNYPAGPL PLPVIGNMWS MMRNNSGVEC FRQWTKDFGD  60
   61 VYTFWFGTKP YIVVSSYKRL KEAFILDGDT FADKIRQPFQ DQFRGGNYGV VDTNGHVWST 120
  121 HRRFALSSFR DFGLGKNLLQ EKMLIEVQDM FAKFDANLGK EQNLPVVLYN AAANVINQLI 180
  181 FGYRFDKERE GELKKLKALM EFQETAFTTF KVYVQFFAPA IGKHLPGKSV EDLLAEFTVD 240
  241 FYKFFNHQIE EHRSKIDFDS EESLDYAEAY LKEQRKQEAQ GEFELFSTKQ LSNTCFDLWF 300
  301 AGLSTTHITL TWIVGHVLNY PDVQRKLHKE LDEVIGSDRL ITNDDKNNLP YLNAVINESQ 360
  361 RCANIVPINQ IHSTSRDTVI NGITVKKGTG VIPQISAIML DDKVFPDPYA FNPERFLDAN 420
  421 GKLRKI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 89.39794
Match: 1pq2A
Description: Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 3.99744233006162 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.24344797738248 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.41884363121524 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 2.36480328243514 bayes_pls_golite062009
arachidonic acid monooxygenase activity 2.35162461983176 bayes_pls_golite062009
sterol 14-demethylase activity 2.33937429425924 bayes_pls_golite062009
oxidoreductase activity 2.31118630300684 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 2.27465774301343 bayes_pls_golite062009
oxygen binding 1.94999422900255 bayes_pls_golite062009
demethylase activity 1.89119521471262 bayes_pls_golite062009
steroid 7-alpha-hydroxylase activity 1.85401713490512 bayes_pls_golite062009
corticosterone 18-monooxygenase activity 1.64204907906991 bayes_pls_golite062009
steroid 11-beta-monooxygenase activity 1.64204907906991 bayes_pls_golite062009
retinoid binding 1.55427837836259 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1.46109575978397 bayes_pls_golite062009
isoprenoid binding 1.43053384013166 bayes_pls_golite062009
retinoic acid binding 1.21667685596765 bayes_pls_golite062009
binding 1.0881336564542 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 0.979631262400031 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 0.912493861244809 bayes_pls_golite062009
arachidonic acid epoxygenase activity 0.75181432044872 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009

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