| Protein: | daf-1 |
| Organism: | Caenorhabditis elegans |
| Length: | 669 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
|
Region A: Residues: [1-270] |
1 11 21 31 41 51
| | | | | |
1 MRIRHVVFCL LALVYGAETS DDDLDERTNI FIRDKLIPAL KLAEVTKVNF TRLHLCHCSR 60
61 EVGCNARTTG WVPGIEFLNE TDRSFYENTC YTDGSCYQSA RPSPEISHFG CMDEKSVTDE 120
121 TEFHDTAAKV CTNNTKDPHA TVWICCDKGN FCANETIIHL APGPQQSSTW LILTILALLT 180
181 FIVLLGIAIF LTRKSWEAKF DWYIRFKPKP GDPLRETENN VPMVTMGDGA GSSVPEVAPI 240
241 EQQGSTMSTS AGNSFPPGIM PNNMKDMLDV
|
| Detection Method: |  |
| Confidence: | 3.69897 |
| Match: | 1igrA |
| Description: | Type 1 insulin-like growth factor receptor extracellular domain; Type 1 insulin-like growth factor receptor Cys-rich domain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| growth factor binding | 6.33296746316446 | bayes_pls_golite062009 |
| insulin-like growth factor binding | 4.12271516631296 | bayes_pls_golite062009 |
| insulin-like growth factor I binding | 3.14198260332974 | bayes_pls_golite062009 |
| binding | 3.10942625145915 | bayes_pls_golite062009 |
| protein binding | 3.04595153576805 | bayes_pls_golite062009 |
| transmembrane receptor activity | 2.11274485218746 | bayes_pls_golite062009 |
| receptor activity | 2.04770371945982 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.83752933098717 | bayes_pls_golite062009 |
| kinase activity | 1.80864815034082 | bayes_pls_golite062009 |
| signal transducer activity | 1.716940423168 | bayes_pls_golite062009 |
| molecular transducer activity | 1.716940423168 | bayes_pls_golite062009 |
| enzyme regulator activity | 1.68559458458962 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.6818630115957 | bayes_pls_golite062009 |
| protein kinase activity | 1.64316913174221 | bayes_pls_golite062009 |
| enzyme activator activity | 1.49158544951255 | bayes_pls_golite062009 |
| transferase activity | 1.3977021765186 | bayes_pls_golite062009 |
| insulin-like growth factor II binding | 1.38700019278498 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 0.625443680166071 | bayes_pls_golite062009 |
| glycoprotein binding | 0.41080910982871 | bayes_pls_golite062009 |
| catalytic activity | 0.271811389148807 | bayes_pls_golite062009 |
| protein tyrosine phosphatase activator activity | 0.193211593927368 | bayes_pls_golite062009 |
| phosphatase activator activity | 0.0954126689202188 | bayes_pls_golite062009 |
|
Region A: Residues: [271-669] |
1 11 21 31 41 51
| | | | | |
1 LEETSGSGMG PTTLHKLTIG GQIRLTGRVG SGRFGNVSRG DYRGEAVAVK VFNALDEPAF 60
61 HKETEIFETR MLRHPNVLRY IGSDRVDTGF VTELWLVTEY HPSGSLHDFL LENTVNIETY 120
121 YNLMRSTASG LAFLHNQIGG SKESNKPAMA HRDIKSKNIM VKNDLTCAIG DLGLSLSKPE 180
181 DAASDIIANE NYKCGTVRYL APEILNSTMQ FTVFESYQCA DVYSFSLVMW ETLCRCEDGD 240
241 VLPREAATVI PYIEWTDRDP QDAQMFDVVC TRRLRPTENP LWKDHPEMKH IMEIIKTCWN 300
301 GNPSARFTSY ICRKRMDERQ QLLLDKKAKA VAQTAGVTVQ DRKILGPQKP KDESPANGAP 360
361 RIVQKEIDRE DEQENWRETA KTPNGHISSN DDSSRPLLG
|
| Detection Method: | |
| Confidence: | 66.522879 |
| Match: | 1b6cB |
| Description: | Type I TGF-beta receptor R4 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| activin receptor activity | 9.43409082112081 | bayes_pls_golite062009 |
| activin binding | 7.11944534332244 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 6.41728494915949 | bayes_pls_golite062009 |
| activin receptor activity, type I | 6.1393596497059 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 5.49988294224815 | bayes_pls_golite062009 |
| protein kinase activity | 5.4586557943719 | bayes_pls_golite062009 |
| kinase activity | 5.3287080791198 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.96052051118534 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| transferase activity | 3.97138602499442 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 3.40140621607334 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 3.37600307408153 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 3.37600307408153 | bayes_pls_golite062009 |
| transmembrane receptor activity | 3.1965684217331 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 2.97315540587667 | bayes_pls_golite062009 |
| receptor activity | 2.96273889901429 | bayes_pls_golite062009 |
| molecular transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| signal transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 2.8153155526437 | bayes_pls_golite062009 |
| binding | 2.74863538127007 | bayes_pls_golite062009 |
| growth factor binding | 2.61235080252818 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type I | 2.57601476622612 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| follistatin binding | 2.2292685945544 | bayes_pls_golite062009 |
| tubulin binding | 2.18641675163967 | bayes_pls_golite062009 |
| receptor signaling protein activity | 2.10379226653669 | bayes_pls_golite062009 |
| fibroblast growth factor binding | 2.00819948109978 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| insulin receptor activity | 1.91768456749814 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| microtubule binding | 1.88110801192607 | bayes_pls_golite062009 |
| fibroblast growth factor 1 binding | 1.82118598657067 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| transcription regulator activity | 1.56748951434625 | bayes_pls_golite062009 |
| transforming growth factor beta binding | 1.46877913443522 | bayes_pls_golite062009 |
| nucleic acid binding | 1.46547714006072 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 1.42275431028856 | bayes_pls_golite062009 |
| DNA binding | 1.35333135345112 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 1.30850950497296 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| PTB domain binding | 1.14009984975509 | bayes_pls_golite062009 |
| transporter activity | 1.11833481501707 | bayes_pls_golite062009 |
| transcription factor activity | 1.10928254946881 | bayes_pls_golite062009 |
| insulin binding | 1.03564126441771 | bayes_pls_golite062009 |
| SMAD binding | 1.02108562119195 | bayes_pls_golite062009 |
| transcription activator activity | 0.997272622653026 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.97575992765505 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| amine binding | 0.783881819862438 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.748533008006377 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.705905455086486 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 0.57617745233877 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 0.499492353295369 | bayes_pls_golite062009 |
| protein serine/threonine/tyrosine kinase activity | 0.48345772948903 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.450699332958421 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.401250804041384 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| MAP kinase kinase kinase activity | 0.37115026509016 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type II | 0.365530951355731 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 0.34434685718027 | bayes_pls_golite062009 |
| peptide hormone binding | 0.312169974523858 | bayes_pls_golite062009 |
| kinase binding | 0.26752427107238 | bayes_pls_golite062009 |
| protein complex binding | 0.239339759110451 | bayes_pls_golite062009 |
| cytokine binding | 0.17817111033393 | bayes_pls_golite062009 |
| cell adhesion molecule binding | 0.150740450460731 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 0.148194101970458 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 0.0123645889643007 | bayes_pls_golite062009 |
| protein kinase binding | 0.00674998152095019 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0040394359628233 | bayes_pls_golite062009 |
| SH2 domain binding | 2.96656737540424E-4 | bayes_pls_golite062009 |
