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View Structure Prediction Details

Protein: CE09454
Organism: Caenorhabditis elegans
Length: 726 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE09454.

Description E-value Query
Range		 Subject
Range
ECE1_RAT - Endothelin-converting enzyme 1 OS=Rattus norvegicus GN=Ece1 PE=1 SV=2
 674.0 [0..2] [726..52]

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Predicted Domain #1
Region A:
Residues: [1-76] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAKDKLANP LIALVVFLVL TIIALLATII IMKLNEKPVE PPRVAPIAQK LVAPEKKSRP  60
   61 EPVTNPVTMT RPEPVT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [77-726] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QASKPRNVCE TPGCVTLADQ LLNFQDPSVD PCQDFYKAAC GKYSEHEVAN RRLQKKDIII  60
   61 QRMIKNFLLK NETSESKSEN VMRQVYRTCE GLKNEEIFNA NMKTAFRELF KDIQKIGSWP 120
  121 AADKNWDETK LNLNEMLLNI VKLGSSNFGL FQIRPTEVPF LEVAPDMARS PKVSANFQQI 180
  181 IFDILEKNGL QPDENVIADD VEDYITLEET LSQYAYDYNA EKVQFSKLQA QVPSLKLEKI 240
  241 IEEMMNPNRK KLLVTKVKPR MVAHKHSLFF DEKMNLEKLL KSTPKRTLAN YLIFYYMDHA 300
  301 MNGLSVHDNV IKKRNCEKLV IEYLPKASLR VFVRNHFEKG NLKIVDEMAE ETKKSFIEML 360
  361 QESTWLGADS KKNAILKLEK MGKMIGYPKE FEKKGALDKM FETLKLLPKD TLYGILKKIG 420
  421 RFHMEQGIEF VALETPMDPV LPVLMTNAFY TDRNHLSFLV GYMDDPLFDA TYPKYVNIAL 480
  481 TGNILAHETS HGFDTAGIKR DENGEVRSWM KPEDLKEYGK KTQCLVDQYN EYDDPVFGKN 540
  541 LNGTTTLNEM VADMIGVTVA WKVFEKLDSS KEQKVIGFEN ENIDKLYFRA AALDFCSLPP 600
  601 TTSLVEELTR VHPTGNFRVN GIFSNMPQFA TAFNCPEGSP MNPKTRCSIF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 172.0
Match: 1dmtA
Description: Neutral endopeptidase (neprilysin)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 5.33358263548929 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.99457783001146 bayes_pls_golite062009
bradykinin receptor binding 4.68498310889748 bayes_pls_golite062009
endopeptidase activity 4.16532996235931 bayes_pls_golite062009
metallopeptidase activity 3.94798058866011 bayes_pls_golite062009
metalloendopeptidase activity 3.43236442601127 bayes_pls_golite062009
peptidyl-dipeptidase activity 3.15882456934259 bayes_pls_golite062009
hydrolase activity 2.61181165622708 bayes_pls_golite062009
angiotensin receptor activity 2.47329778652768 bayes_pls_golite062009
G-protein coupled receptor activity 2.40931483220122 bayes_pls_golite062009
exopeptidase activity 2.07461908743946 bayes_pls_golite062009
receptor binding 2.07222569254168 bayes_pls_golite062009
transmembrane receptor activity 1.71636138555452 bayes_pls_golite062009
receptor activity 1.71573921458029 bayes_pls_golite062009
peptide binding 1.58227634414618 bayes_pls_golite062009
protein binding 1.58118182554863 bayes_pls_golite062009
binding 1.55761777216628 bayes_pls_golite062009
molecular transducer activity 1.42071856700201 bayes_pls_golite062009
signal transducer activity 1.42071856700201 bayes_pls_golite062009
viral receptor activity 1.39617252453036 bayes_pls_golite062009
epoxide hydrolase activity 1.37998417474643 bayes_pls_golite062009
ether hydrolase activity 1.18753073809881 bayes_pls_golite062009
protein complex binding 1.16270782056592 bayes_pls_golite062009
integrin binding 0.93449223670512 bayes_pls_golite062009
catalytic activity 0.891187593353827 bayes_pls_golite062009
interleukin-6 receptor binding 0.711782218042781 bayes_pls_golite062009
cytokine receptor binding 0.61233964043845 bayes_pls_golite062009
peptide receptor activity, G-protein coupled 0.597899738932066 bayes_pls_golite062009
peptide receptor activity 0.574641388356132 bayes_pls_golite062009
zinc ion binding 0.49304764842799 bayes_pls_golite062009
hydrolase activity, acting on ether bonds 0.457157426475929 bayes_pls_golite062009
serine hydrolase activity 0.393080846858665 bayes_pls_golite062009
serine-type peptidase activity 0.374597710524442 bayes_pls_golite062009
growth factor activity 0.259654587796416 bayes_pls_golite062009
serine-type endopeptidase activity 0.252655558968584 bayes_pls_golite062009
aminopeptidase activity 0.21808506596674 bayes_pls_golite062009
transition metal ion binding 0.21514043665594 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle