| Protein: | mcm-5 |
| Organism: | Caenorhabditis elegans |
| Length: | 759 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mcm-5.
| Description | E-value | Query Range |
Subject Range |
|
|
565.0 | [0..1] | [759..1] |
|
Region A: Residues: [1-255] |
1 11 21 31 41 51
| | | | | |
1 MSNLDNPGIY YQERFFANDG VPDTGRELIA EYRQLITQFR NFIRDFSTGG FGMIYRDQLK 60
61 RNYFSHEYRL EINLNHLKNF DEDIEMKLRK FPGKVLPALE EAAKIVADEI TTPRPKGEEK 120
121 LHDIQVTLTL DEYPTSLRQV KSAQVSQVVK ISGIIVAAAQ VRSKATKVTL QCRQCKHTIP 180
181 DVSIKPGLEG FALPRTCAAP QQGQMQRCPI DPYIMLPDKC ECVDYQTLKL QENPEDVPHG 240
241 EMPRHLQLFT ERYLT
|
| Detection Method: |  |
| Confidence: | 46.0 |
| Match: | 1ltlA |
| Description: | DNA replication initiator (cdc21/cdc54) N-terminal domain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| telomeric DNA binding | 4.81350293592083 | bayes_pls_golite062009 |
| telomerase inhibitor activity | 4.48082903165152 | bayes_pls_golite062009 |
| single-stranded telomeric DNA binding | 4.34033743483519 | bayes_pls_golite062009 |
| nucleic acid binding | 4.29626483284963 | bayes_pls_golite062009 |
| DNA binding | 3.71771169141041 | bayes_pls_golite062009 |
| structural constituent of ribosome | 3.51998515668903 | bayes_pls_golite062009 |
| structural molecule activity | 3.29857127235306 | bayes_pls_golite062009 |
| structure-specific DNA binding | 3.06066809614422 | bayes_pls_golite062009 |
| single-stranded DNA binding | 3.0183551365402 | bayes_pls_golite062009 |
| binding | 2.83465364476231 | bayes_pls_golite062009 |
| transcription regulator activity | 2.10110937001387 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 1.9581702424972 | bayes_pls_golite062009 |
| DNA replication origin binding | 1.84819558112187 | bayes_pls_golite062009 |
| translation regulator activity | 1.46320772716954 | bayes_pls_golite062009 |
| translation factor activity, nucleic acid binding | 1.40718318783582 | bayes_pls_golite062009 |
| transcription repressor activity | 1.30343463892105 | bayes_pls_golite062009 |
| translation initiation factor activity | 1.27539679024898 | bayes_pls_golite062009 |
| transcription activator activity | 1.24141936405635 | bayes_pls_golite062009 |
| protein binding | 1.20309946451799 | bayes_pls_golite062009 |
| DNA-directed RNA polymerase activity | 1.19766815287926 | bayes_pls_golite062009 |
| RNA polymerase activity | 1.19766815287926 | bayes_pls_golite062009 |
| ribonuclease activity | 1.19236946227657 | bayes_pls_golite062009 |
| transcription factor activity | 1.14242112812892 | bayes_pls_golite062009 |
| DNA helicase activity | 1.12203697857261 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 0.638831894247026 | bayes_pls_golite062009 |
| nuclease activity | 0.57381531077345 | bayes_pls_golite062009 |
| aminoacyl-tRNA ligase activity | 0.474251377131502 | bayes_pls_golite062009 |
| ligase activity, forming carbon-oxygen bonds | 0.47336621289748 | bayes_pls_golite062009 |
| ligase activity, forming aminoacyl-tRNA and related compounds | 0.47336621289748 | bayes_pls_golite062009 |
| nucleotidyltransferase activity | 0.325774164899685 | bayes_pls_golite062009 |
| four-way junction helicase activity | 0.31769813397725 | bayes_pls_golite062009 |
| exonuclease activity | 0.28313884527829 | bayes_pls_golite062009 |
| RNA binding | 0.18502033889261 | bayes_pls_golite062009 |
| exoribonuclease activity, producing 5'-phosphomonoesters | 0.125256208482441 | bayes_pls_golite062009 |
| exoribonuclease activity | 0.109774918833391 | bayes_pls_golite062009 |
| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 0.0954216620147701 | bayes_pls_golite062009 |
| DEAD/H-box RNA helicase binding | 0.0627405398613412 | bayes_pls_golite062009 |
| ATP-dependent DNA helicase activity | 0.0179535526984695 | bayes_pls_golite062009 |
| helicase activity | 0.0121541775159524 | bayes_pls_golite062009 |
|
Region A: Residues: [256-338] |
1 11 21 31 41 51
| | | | | |
1 DKVVPGNRVT IVGVYSIKKL IQKKGGDKSL QGIRTPYLRV LGIHMETSGP GRTNFTTFTP 60
61 EEERMFKTLA QRKDAYELIA KSI
|
| Detection Method: | |
| Confidence: | 52.69897 |
| Match: | 1ny5A |
| Description: | Crystal structure of sigm54 activator (AAA+ ATPase) in the inactive state |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [339-759] |
1 11 21 31 41 51
| | | | | |
1 APSIYGSADI KKSIACLLFG GARKKLPDGI TRRGDINVLL LGDPGTAKSQ LLKFVEQVSP 60
61 IGVYTSGKGS SAAGLTASVI RDPQSRSFIM EGGAMVLADG GVVCIDEFDK MREDDRVAIH 120
121 EAMEQQTISI AKAGITTTLN SRCSVLAAAN SVYGRWDESR GDDNIDFMPT ILSRFDMIYI 180
181 VKDTHDVLKD ATLAKHVIEV HVNASAAKER DIAGVPKTAT TDSDGVMTMF DTDGFLTIEF 240
241 LKKFVTYARL NCGPRLTPQA SEKLVNHYVK MRNPVVNADA FKSGKKAHNS AIPITVRQLE 300
301 AIVRIAESIA KMELQQFATD KHVEEALRLF RVSTIEAAAT GNLAGVEGFT STADQEALNR 360
361 IEVQMKKRFA IGTHVSEHLI VQDFVARQHY RESLVKKVID NLVRRGDLQQ KMQRKMLYRV 420
421 R
|
| Detection Method: | |
| Confidence: | 35.39794 |
| Match: | 2ce7A |
| Description: | EDTA treated |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| DNA clamp loader activity | 4.91429252297969 | bayes_pls_golite062009 |
| protein-DNA loading ATPase activity | 4.80695929076807 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 2.72462789867829 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 2.66107861968804 | bayes_pls_golite062009 |
| binding | 2.64537357529343 | bayes_pls_golite062009 |
| nucleic acid binding | 2.51683451033161 | bayes_pls_golite062009 |
| DNA helicase activity | 2.2817164193758 | bayes_pls_golite062009 |
| pyrophosphatase activity | 2.13284212711072 | bayes_pls_golite062009 |
| DNA binding | 2.12258000781149 | bayes_pls_golite062009 |
| transcription regulator activity | 2.09345198747025 | bayes_pls_golite062009 |
| telomeric DNA binding | 2.0142766759353 | bayes_pls_golite062009 |
| ATP-dependent DNA helicase activity | 1.88455339138556 | bayes_pls_golite062009 |
| helicase activity | 1.70242731830224 | bayes_pls_golite062009 |
| microtubule motor activity | 1.6537049553461 | bayes_pls_golite062009 |
| DNA replication origin binding | 1.62491387774159 | bayes_pls_golite062009 |
| structural constituent of ribosome | 1.47858140861683 | bayes_pls_golite062009 |
| protein binding | 1.22129154759482 | bayes_pls_golite062009 |
| purine NTP-dependent helicase activity | 1.19311444180077 | bayes_pls_golite062009 |
| ATP-dependent helicase activity | 1.19311444180077 | bayes_pls_golite062009 |
| motor activity | 1.14667913749579 | bayes_pls_golite062009 |
| lysine N-acetyltransferase activity | 1.05990253628867 | bayes_pls_golite062009 |
| histone acetyltransferase activity | 1.05990253628867 | bayes_pls_golite062009 |
| catalytic activity | 1.00104173493322 | bayes_pls_golite062009 |
| DNA-directed DNA polymerase activity | 0.971476020912368 | bayes_pls_golite062009 |
| DNA polymerase activity | 0.928091843881235 | bayes_pls_golite062009 |
| transcription activator activity | 0.889929694023098 | bayes_pls_golite062009 |
| transcription factor activity | 0.887108427603557 | bayes_pls_golite062009 |
| structural molecule activity | 0.86514677273731 | bayes_pls_golite062009 |
| transcription repressor activity | 0.862685397469217 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.782430219754236 | bayes_pls_golite062009 |
| single-stranded telomeric DNA binding | 0.700780808446722 | bayes_pls_golite062009 |
| double-stranded DNA binding | 0.6071273686445 | bayes_pls_golite062009 |
| purine nucleotide binding | 0.569910969126728 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 0.568840867400671 | bayes_pls_golite062009 |
| ribonucleotide binding | 0.568779924702229 | bayes_pls_golite062009 |
| nucleotide binding | 0.564275755355315 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 0.543891899378373 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.500462538667228 | bayes_pls_golite062009 |
| translation regulator activity | 0.29096092258568 | bayes_pls_golite062009 |
| translation factor activity, nucleic acid binding | 0.274994961137851 | bayes_pls_golite062009 |
| four-way junction helicase activity | 0.26252931460003 | bayes_pls_golite062009 |
| ATP binding | 0.1860481660648 | bayes_pls_golite062009 |
| exodeoxyribonuclease V activity | 0.185603938981231 | bayes_pls_golite062009 |
| RNA helicase activity | 0.18426050934025 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 0.152859582615242 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.147579541298736 | bayes_pls_golite062009 |
| RNA-dependent ATPase activity | 0.14606996093053 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 0.138615225841109 | bayes_pls_golite062009 |
| ATP-dependent RNA helicase activity | 0.13050483816765 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 0.113504049290503 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.111293884322157 | bayes_pls_golite062009 |
| 3'-5' DNA helicase activity | 0.0769112340058804 | bayes_pls_golite062009 |
| actin binding | 0.00482938540552702 | bayes_pls_golite062009 |
