YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC25B2.01
Organism:	Schizosaccharomyces pombe
Length:	592 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC25B2.01.

Description	E-value	Query Range	Subject Range
gi\|32417430, gi\|... - gi\|32417430\|ref\|XP_329193.1\| ELONGATION FACTOR 1-ALPHA (EF-1-ALPHA) [Neurospora crassa], gi\|28926664... gi\|85115405 - gi\|85115405\|ref\|XP_964868.1\| ELONGATION FACTOR 1-ALPHA (EF-1-ALPHA) [Neurospora crassa OR74A]	433.0	[0..170]	[591..23]
gi\|37730263, gi\|... - gi\|37730267\|gb\|AAO60081.1\| translation elongation factor 1-alpha [Pichia angusta], gi\|37730263\|gb\|AA...	432.0	[0..171]	[591..1]
EF1A_CHICK - Elongation factor 1-alpha 1 OS=Gallus gallus GN=EEF1A PE=2 SV=1	431.0	[0..171]	[591..1]
EF1A1_RAT - Elongation factor 1-alpha 1 OS=Rattus norvegicus GN=Eef1a1 PE=2 SV=1 gi\|190344037 - gi\|190344037\|gb\|ACE75815.1\| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Sorex ar... EF1A1_MOUSE - Elongation factor 1-alpha 1 OS=Mus musculus GN=Eef1a1 PE=1 SV=3 gi\|183398094 - gi\|183398094\|gb\|ACC62508.1\| elongation factor 1 alpha (predicted) [Rhinolophus ferrumequinum] gi\|220279 - gi\|220279\|dbj\|BAA00409.1\| EF-1 alpha [Cricetulus longicaudatus] EF1A1_CRIGR - Elongation factor 1-alpha 1 OS=Cricetulus griseus GN=EEF1A1 PE=2 SV=1 gi\|53734423 - gb\|AAH84017.1\| Unknown (protein for MGC:98187) [Xenopus laevis]	431.0	[0..171]	[591..1]
gi\|74195737 - gi\|74195737\|dbj\|BAE30434.1\| unnamed protein product [Mus musculus]	431.0	[0..171]	[591..1]
gi\|62897525 - gi\|62897525\|dbj\|BAD96702.1\| eukaryotic translation elongation factor 1 alpha 1 variant [Homo sapiens...	431.0	[0..171]	[591..1]

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Predicted Domain #1

Region A:
Residues: [1-76]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRHRDVKNL DLDDYELDEE PGEEELTEEQ EEEFRSAVAT VRETLLGVPI SEKEIADTVW  60
   61 YYYFDVEKSV NYLLQK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [77-170]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASSKAGAKEK QNTDSQKEKK QNKSKEALAD AKDPLDESSN GIKNLSLNKN DEPAFQTNGE  60
   61 VKMKNSSESD NQPEKKKIKK QNPTDLVSVP EIFE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	21.69897
Match:	2hjgA
Description:	No description for 2hjgA was found.

Predicted Domain #3

Region A:
Residues: [171-592]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSNPKPVVHL VVTGHVDSGK STMLGRIMFE LGEINSRSMQ KLHNEAANSG KGSFSYAWLL  60
   61 DTTEEERARG VTMDVASTTF ESDKKIYEIG DAPGHRDFIS GMIAGASSAD FAVLVVDSSQ 120
  121 NNFERGFLEN GQTREHAYLL RALGISEIVV SVNKLDLMSW SEDRFQEIKN IVSDFLIKMV 180
  181 GFKTSNVHFV PISAISGTNL IQKDSSDLYK WYKGPTLLSA LDQLVPPEKP YRKPLRLSID 240
  241 DVYRSPRSVT VTGRVEAGNV QVNQVLYDVS SQEDAYVKNV IRNSDPSSTW AVAGDTVTLQ 300
  301 LADIEVNQLR PGDILSNYEN PVRRVRSFVA EIQTFDIHGP ILSGSTLVLH LGRTVTSVSL 360
  361 KIVTVNNKRS RHIASRKRAL VRISFLDGLF PLCLAEECPA LGRFILRRSG DTVAAGIVKE 420
  421 LC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	119.0
Match:	1f60A
Description:	Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation elongation factor activity	8.90683166637832	bayes_pls_golite062009
translation factor activity, nucleic acid binding	4.8378725567094	bayes_pls_golite062009
translation regulator activity	4.79814772079421	bayes_pls_golite062009
structural constituent of ribosome	4.56509805974548	bayes_pls_golite062009
structural molecule activity	3.58406348799895	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
transporter activity	2.58140740499725	bayes_pls_golite062009
hydrolase activity	2.55157966585974	bayes_pls_golite062009
translation release factor activity	2.49148102494524	bayes_pls_golite062009
translation termination factor activity	2.46464632547226	bayes_pls_golite062009
transmembrane transporter activity	2.39695871109024	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
RNA binding	2.29590582680214	bayes_pls_golite062009
ATPase activity, coupled	2.18396165590908	bayes_pls_golite062009
actin filament binding	2.1683792904715	bayes_pls_golite062009
	2.15810909411803	bayes_pls_golite062009
motor activity	2.11140484670646	bayes_pls_golite062009
nucleic acid binding	1.49633029954726	bayes_pls_golite062009
actin binding	1.42666717383185	bayes_pls_golite062009
cytoskeletal protein binding	1.40488517180956	bayes_pls_golite062009
microtubule motor activity	1.35938517416356	bayes_pls_golite062009
microfilament motor activity	1.33993901826495	bayes_pls_golite062009
substrate-specific transporter activity	1.29730375126024	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
transcription regulator activity	0.989226939888218	bayes_pls_golite062009
ATP binding	0.98146619596929	bayes_pls_golite062009
DNA binding	0.967303417236485	bayes_pls_golite062009
adenyl ribonucleotide binding	0.949788783884952	bayes_pls_golite062009
adenyl nucleotide binding	0.931486373329219	bayes_pls_golite062009
purine nucleotide binding	0.929901285538132	bayes_pls_golite062009
nucleotide binding	0.922442819194247	bayes_pls_golite062009
purine ribonucleotide binding	0.920987930180051	bayes_pls_golite062009
ribonucleotide binding	0.920926158369519	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.906554174337376	bayes_pls_golite062009
protein methyltransferase activity	0.876296121718575	bayes_pls_golite062009
mRNA binding	0.76699944561918	bayes_pls_golite062009
kinase activity	0.691112783105676	bayes_pls_golite062009
histone methyltransferase activity	0.63002958837536	bayes_pls_golite062009
RNA helicase activity	0.6022754485555	bayes_pls_golite062009
peptidyltransferase activity	0.515626975889911	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.499834566483656	bayes_pls_golite062009
GTPase activity	0.437665353870877	bayes_pls_golite062009
active transmembrane transporter activity	0.434775387083003	bayes_pls_golite062009
ion transmembrane transporter activity	0.355466224802969	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	0.353150780751661	bayes_pls_golite062009
guanyl nucleotide binding	0.296406132096546	bayes_pls_golite062009
GTP binding	0.295705904888768	bayes_pls_golite062009
primary active transmembrane transporter activity	0.294474570607914	bayes_pls_golite062009
guanyl ribonucleotide binding	0.29028316917561	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.282352478532746	bayes_pls_golite062009
ribonuclease activity	0.222424272323909	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.220608508617331	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.219533217661421	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.219157471322311	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
anion transmembrane transporter activity	0.14873140406343	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	0.12168417344278	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009
transcription factor activity	0.0434163635422169	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.0430764033739892	bayes_pls_golite062009
protein transporter activity	0.0397092337273124	bayes_pls_golite062009
protein kinase activity	0.0364322017534667	bayes_pls_golite062009
cation transmembrane transporter activity	0.0254369227200564	bayes_pls_golite062009
peptide transporter activity	0.0135927378126404	bayes_pls_golite062009
signal sequence binding	6.53725193420218E-4	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: