YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC543.09
Organism:	Schizosaccharomyces pombe
Length:	773 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC543.09.

Description	E-value	Query Range	Subject Range
gi\|74211696 - gi\|74211696\|dbj\|BAE29204.1\| unnamed protein product [Mus musculus]	566.0	[0..19]	[761..22]
gi\|109507457, gi... - ref\|XP_225866.2\| similar to 2310036I02Rik protein [Rattus norvegicus], gi\|198442897\|ref\|NP_001128336...	557.0	[0..19]	[761..22]
gi\|109121512 - gi\|109121512\|ref\|XP_001094146.1\| PREDICTED: AFG3 ATPase family gene 3-like 2 isoform 2 [Macaca mulat...	541.0	[0..34]	[761..36]
AFG3L2 - AFG3 ATPase family gene 3-like 2 (yeast)	541.0	[0..19]	[761..23]
gi\|114672121 - gi\|114672121\|ref\|XP_512199.2\| PREDICTED: AFG3 ATPase family gene 3-like 2 isoform 3 [Pan troglodytes...	541.0	[0..19]	[761..23]

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Predicted Domain #1

Region A:
Residues: [1-123]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRNPFLTFRA PTRKTGDYLV SKFVKKDNFS SLRLARAYTF STRSTAVSQF SLLSLSQRSF  60
   61 QSLKINKGIP EKHKIPLISS KQFSVTSKRS QNGSSGSNSD ANGRKNGQKN DDSKKKGLNG 120
  121 NDP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [124-156]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKVFEIALNG NTILGGILVA YILYNVLSPN ANM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.0
Match:	1oz4A
Description:	VCP/p97
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [157-671]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEITWQDFRQ QFLDKGLVER LVVVNRNMVR VILRGGVASG SGQYYFSIGS IDSFDRKLED  60
   61 AQRQLGIPPS EFVPVAYHDE VSVLATLLSF APTLLIIGSV IYLSRRASGA AGGGQGGIFG 120
  121 IGKSRAKMFN HETDIKIKFA DVAGVDEAKE EIMEFVKFLK NPKFYERLGA KIPRGAILSG 180
  181 PPGTGKTLLA KATAGEANVP FLSVSGSEFL EMFVGVGPSR VRDLFATARK NAPCIIFIDE 240
  241 IDAIGKARGR GGQFGSNDER ESTLNQLLVE MDGFTSSEHI VVFAGTNRPD VLDPALLRPG 300
  301 RFDRQITIDR PDIGGREQIF KVHLKHIKAA DNIDLIAKRL AVLTSGFTGA DIMNVCNEGA 360
  361 LIAARSNSNE VQMVHFEQAI ERVTAGLEKK SRVLSPEEKN TVAHHEAGHA VAGWFMEYVD 420
  421 PLLKVSIIPR AQALGYASYL PKDQYLMSRG QILDQMGMAL AGRVSEEIFF GPEKITSGAS 480
  481 DDFQKVTRMA QAYVTQYGMS PTVGTIAYPI DTRET

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	25.0
Match:	1ksfX
Description:	N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone; ClpA, an Hsp100 chaperone, AAA+ modules
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrogen ion transporting ATP synthase activity, rotational mechanism	3.57926427233638	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
primary active transmembrane transporter activity	2.61775212528604	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.61467977505707	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.61311581579476	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.57552435627908	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.57107347424517	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.57054427875021	bayes_pls_golite062009
hydrolase activity	2.55157966585974	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	2.50934147358924	bayes_pls_golite062009
active transmembrane transporter activity	2.50494515048649	bayes_pls_golite062009
ATPase activity, coupled	2.43862163407966	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
binding	2.0681607836408	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.56325751172863	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
ion transmembrane transporter activity	0.977237423302079	bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity	0.97313818590443	bayes_pls_golite062009
macromolecule transmembrane transporter activity	0.97313818590443	bayes_pls_golite062009
purine nucleotide binding	0.929901285538132	bayes_pls_golite062009
nucleotide binding	0.922442819194247	bayes_pls_golite062009
purine ribonucleotide binding	0.920987930180051	bayes_pls_golite062009
ribonucleotide binding	0.920926158369519	bayes_pls_golite062009
motor activity	0.87979065815418	bayes_pls_golite062009
nucleic acid binding	0.831762535895849	bayes_pls_golite062009
guanyl nucleotide binding	0.640772201693186	bayes_pls_golite062009
guanyl ribonucleotide binding	0.63468044350616	bayes_pls_golite062009
GTP binding	0.621689261700018	bayes_pls_golite062009
cation transmembrane transporter activity	0.557919489256916	bayes_pls_golite062009
protein transporter activity	0.498432226280822	bayes_pls_golite062009
drug transmembrane transporter activity	0.46842047319323	bayes_pls_golite062009
protein transmembrane transporter activity	0.46552249844591	bayes_pls_golite062009
GTPase activity	0.437665353870877	bayes_pls_golite062009
ATP binding	0.41092997612902	bayes_pls_golite062009
adenyl ribonucleotide binding	0.385813421701492	bayes_pls_golite062009
protein binding	0.378225828131122	bayes_pls_golite062009
adenyl nucleotide binding	0.377870145186619	bayes_pls_golite062009
	0.3586311431823	bayes_pls_golite062009
signal recognition particle binding	0.29390189699022	bayes_pls_golite062009
DNA binding	0.143403729737365	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.123304946374679	bayes_pls_golite062009
microtubule motor activity	0.11674780318211	bayes_pls_golite062009
transcription regulator activity	0.0147430141176288	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [672-773]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQKPFSEATA QMIDEEIRKL VKHAYERTKK LLLEHKQGLE NIAQRLLQKE VITYNEVETI  60
   61 LGPRPYAYKH LNISELMRQS EYKNDHDPRN PPIPPSPQQP SA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	114.0
Match:	2ce7A
Description:	EDTA treated
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: