| Protein: | mcm2 |
| Organism: | Schizosaccharomyces pombe |
| Length: | 830 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mcm2.
| Description | E-value | Query Range |
Subject Range |
|
|
674.0 | [0..4] | [829..13] |
|
|
669.0 | [0..1] | [829..20] |
|
|
668.0 | [0..1] | [829..1] |
|
|
668.0 | [0..1] | [829..1] |
|
Region A: Residues: [1-175] |
1 11 21 31 41 51
| | | | | |
1 MDSFRKRGRR DSESLPFESE NSSLGATPLS LPPSSPPPEF SDEAAEALVE EDIEDLDGEA 60
61 LDVEDEEGED LFGEGMERDY QQNLELDRYD IEELDDDNDL EELDIGARRA VDARLRRRDI 120
121 ELDAAAGRTK PAAFLQDEDD DLDSNLGTGF TRHRHRIYDE YSPNVGALDE SGELP
|
| Detection Method: |  |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [176-362] |
1 11 21 31 41 51
| | | | | |
1 LESIADVKAD SIAEWVTLDP VRRTIAREFK NFLLEYTDEN GTSVYGNRIR TLGEVNAESL 60
61 MVNYAHLGES KPILAYFLAN APAPIFRIFD RVALEATLLH YPDYERIHSD IHVRITNLPT 120
121 CFTLRDLRQS HLNCLVRVSG VVTRRTGLFP QLKYIRFTCT KCGATLGPFF QDSSVEVKIS 180
181 FCHNCSS
|
| Detection Method: | |
| Confidence: | 37.522879 |
| Match: | 1ltlA |
| Description: | DNA replication initiator (cdc21/cdc54) N-terminal domain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| telomeric DNA binding | 4.81350293592083 | bayes_pls_golite062009 |
| telomerase inhibitor activity | 4.48082903165152 | bayes_pls_golite062009 |
| single-stranded telomeric DNA binding | 4.34033743483519 | bayes_pls_golite062009 |
| nucleic acid binding | 4.29626483284963 | bayes_pls_golite062009 |
| DNA binding | 3.71771169141041 | bayes_pls_golite062009 |
| structural constituent of ribosome | 3.51998515668903 | bayes_pls_golite062009 |
| structural molecule activity | 3.29857127235306 | bayes_pls_golite062009 |
| structure-specific DNA binding | 3.06066809614422 | bayes_pls_golite062009 |
| single-stranded DNA binding | 3.0183551365402 | bayes_pls_golite062009 |
| binding | 2.83465364476231 | bayes_pls_golite062009 |
| transcription regulator activity | 2.10110937001387 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 1.9581702424972 | bayes_pls_golite062009 |
| DNA replication origin binding | 1.84819558112187 | bayes_pls_golite062009 |
| translation regulator activity | 1.46320772716954 | bayes_pls_golite062009 |
| translation factor activity, nucleic acid binding | 1.40718318783582 | bayes_pls_golite062009 |
| transcription repressor activity | 1.30343463892105 | bayes_pls_golite062009 |
| translation initiation factor activity | 1.27539679024898 | bayes_pls_golite062009 |
| transcription activator activity | 1.24141936405635 | bayes_pls_golite062009 |
| protein binding | 1.20309946451799 | bayes_pls_golite062009 |
| DNA-directed RNA polymerase activity | 1.19766815287926 | bayes_pls_golite062009 |
| RNA polymerase activity | 1.19766815287926 | bayes_pls_golite062009 |
| ribonuclease activity | 1.19236946227657 | bayes_pls_golite062009 |
| transcription factor activity | 1.14242112812892 | bayes_pls_golite062009 |
| DNA helicase activity | 1.12203697857261 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 0.638831894247026 | bayes_pls_golite062009 |
| nuclease activity | 0.57381531077345 | bayes_pls_golite062009 |
| aminoacyl-tRNA ligase activity | 0.474251377131502 | bayes_pls_golite062009 |
| ligase activity, forming carbon-oxygen bonds | 0.47336621289748 | bayes_pls_golite062009 |
| ligase activity, forming aminoacyl-tRNA and related compounds | 0.47336621289748 | bayes_pls_golite062009 |
| nucleotidyltransferase activity | 0.325774164899685 | bayes_pls_golite062009 |
| four-way junction helicase activity | 0.31769813397725 | bayes_pls_golite062009 |
| exonuclease activity | 0.28313884527829 | bayes_pls_golite062009 |
| RNA binding | 0.18502033889261 | bayes_pls_golite062009 |
| exoribonuclease activity, producing 5'-phosphomonoesters | 0.125256208482441 | bayes_pls_golite062009 |
| exoribonuclease activity | 0.109774918833391 | bayes_pls_golite062009 |
| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 0.0954216620147701 | bayes_pls_golite062009 |
| DEAD/H-box RNA helicase binding | 0.0627405398613412 | bayes_pls_golite062009 |
| ATP-dependent DNA helicase activity | 0.0179535526984695 | bayes_pls_golite062009 |
| helicase activity | 0.0121541775159524 | bayes_pls_golite062009 |
|
Region A: Residues: [363-759] |
1 11 21 31 41 51
| | | | | |
1 RGPFVINSER TVYNNYQRIT LQESPGTVPS GRLPRHREVI LLADLVDVAK PGEEIDVTGI 60
61 YRNNFDASLN TKNGFPVFAT IIEANHISQL DGSGNTDDDF SLSRLTDDEE REIRALAKSP 120
121 DIHNRIIASM APSIYGHRSI KTAIAAALFG GVPKNINGKH KIRGDINVLL LGDPGTAKSQ 180
181 FLKYVEKTAH RAVFATGQGA SAVGLTASVR KDPITNEWTL EGGALVLADK GVCLIDEFDK 240
241 MNDQDRTSIH EAMEQQSISI SKAGIVTTLQ ARCTIIAAAN PIGGRYNTTI PFNQNVELTE 300
301 PILSRFDILQ VVKDTVNPEI DEQLANFVVS SHIRSHPAFD PNMDVLKKVP TETGIDAKPI 360
361 PQDLLRKYIH FAREKVFPRL QQMDEEKISR LYSDMRR
|
| Detection Method: | |
| Confidence: | 31.522879 |
| Match: | 1ksfX |
| Description: | N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone; ClpA, an Hsp100 chaperone, AAA+ modules |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| DNA clamp loader activity | 4.91429252297969 | bayes_pls_golite062009 |
| protein-DNA loading ATPase activity | 4.80695929076807 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 2.72462789867829 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 2.66107861968804 | bayes_pls_golite062009 |
| binding | 2.64537357529343 | bayes_pls_golite062009 |
| nucleic acid binding | 2.51683451033161 | bayes_pls_golite062009 |
| DNA helicase activity | 2.2817164193758 | bayes_pls_golite062009 |
| pyrophosphatase activity | 2.13284212711072 | bayes_pls_golite062009 |
| DNA binding | 2.12258000781149 | bayes_pls_golite062009 |
| transcription regulator activity | 2.09345198747025 | bayes_pls_golite062009 |
| telomeric DNA binding | 2.0142766759353 | bayes_pls_golite062009 |
| ATP-dependent DNA helicase activity | 1.88455339138556 | bayes_pls_golite062009 |
| helicase activity | 1.70242731830224 | bayes_pls_golite062009 |
| microtubule motor activity | 1.6537049553461 | bayes_pls_golite062009 |
| DNA replication origin binding | 1.62491387774159 | bayes_pls_golite062009 |
| structural constituent of ribosome | 1.47858140861683 | bayes_pls_golite062009 |
| protein binding | 1.22129154759482 | bayes_pls_golite062009 |
| purine NTP-dependent helicase activity | 1.19311444180077 | bayes_pls_golite062009 |
| ATP-dependent helicase activity | 1.19311444180077 | bayes_pls_golite062009 |
| motor activity | 1.14667913749579 | bayes_pls_golite062009 |
| lysine N-acetyltransferase activity | 1.05990253628867 | bayes_pls_golite062009 |
| histone acetyltransferase activity | 1.05990253628867 | bayes_pls_golite062009 |
| catalytic activity | 1.00104173493322 | bayes_pls_golite062009 |
| DNA-directed DNA polymerase activity | 0.971476020912368 | bayes_pls_golite062009 |
| DNA polymerase activity | 0.928091843881235 | bayes_pls_golite062009 |
| transcription activator activity | 0.889929694023098 | bayes_pls_golite062009 |
| transcription factor activity | 0.887108427603557 | bayes_pls_golite062009 |
| structural molecule activity | 0.86514677273731 | bayes_pls_golite062009 |
| transcription repressor activity | 0.862685397469217 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.782430219754236 | bayes_pls_golite062009 |
| single-stranded telomeric DNA binding | 0.700780808446722 | bayes_pls_golite062009 |
| double-stranded DNA binding | 0.6071273686445 | bayes_pls_golite062009 |
| purine nucleotide binding | 0.569910969126728 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 0.568840867400671 | bayes_pls_golite062009 |
| ribonucleotide binding | 0.568779924702229 | bayes_pls_golite062009 |
| nucleotide binding | 0.564275755355315 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 0.543891899378373 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.500462538667228 | bayes_pls_golite062009 |
| translation regulator activity | 0.29096092258568 | bayes_pls_golite062009 |
| translation factor activity, nucleic acid binding | 0.274994961137851 | bayes_pls_golite062009 |
| four-way junction helicase activity | 0.26252931460003 | bayes_pls_golite062009 |
| ATP binding | 0.1860481660648 | bayes_pls_golite062009 |
| exodeoxyribonuclease V activity | 0.185603938981231 | bayes_pls_golite062009 |
| RNA helicase activity | 0.18426050934025 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 0.152859582615242 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.147579541298736 | bayes_pls_golite062009 |
| RNA-dependent ATPase activity | 0.14606996093053 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 0.138615225841109 | bayes_pls_golite062009 |
| ATP-dependent RNA helicase activity | 0.13050483816765 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 0.113504049290503 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.111293884322157 | bayes_pls_golite062009 |
| 3'-5' DNA helicase activity | 0.0769112340058804 | bayes_pls_golite062009 |
| actin binding | 0.00482938540552702 | bayes_pls_golite062009 |
|
Region A: Residues: [760-830] |
1 11 21 31 41 51
| | | | | |
1 ESLATGSYPI TVRHLESAIR LSEAFAKMQL SEFVRPSHID KAIQVIIDSF VNAQKMSVKR 60
61 SLSRTFAKYL I
|
| Detection Method: | |
| Confidence: | 36.69897 |
| Match: | 2r44A |
| Description: | No description for 2r44A was found. |
