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View Structure Prediction Details

Protein: lon1
Organism: Schizosaccharomyces pombe
Length: 1067 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lon1.

Description E-value Query
Range
Subject
Range
LONM_EMENI - Lon protease homolog, mitochondrial OS=Emericella nidulans GN=pim1 PE=3 SV=1
LONM_EMENI - Lon protease homolog, mitochondrial OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46...
570.0 [0..32] [1067..55]
gi|28923404, gi|... - gi|32408273|ref|XP_324618.1| hypothetical protein [Neurospora crassa], gi|28923404|gb|EAA32590.1| AT...
LONM_NEUCR - Lon protease homolog, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.7...
544.0 [0..30] [1048..53]
gi|14719366 - gi|14719366|gb|AAK73158.1| lon proteinase [Paracoccidioides brasiliensis]
541.0 [0..4] [1063..23]
gi|90299767, gi|... - gi|90299767|gb|EAS29398.1| hypothetical protein CIMG_08144 [Coccidioides immitis RS], gi|119178672|r...
537.0 [0..15] [1064..11]
gi|159129574 - gi|159129574|gb|EDP54688.1| LON domain serine protease, putative [Aspergillus fumigatus A1163]
LONM_ASPFU - Lon protease homolog, mitochondrial OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 1013...
537.0 [0..32] [1060..56]
gi|115383860, gi... - gi|115383860|ref|XP_001208477.1| ATP-dependent protease La [Aspergillus terreus NIH2624], gi|1141961...
534.0 [0..1] [1064..20]
gi|74182120 - gi|74182120|dbj|BAE34094.1| unnamed protein product [Mus musculus]
531.0 [0..103] [1051..53]
LONM_RAT - Lon protease homolog, mitochondrial OS=Rattus norvegicus GN=Lonp1 PE=2 SV=1
530.0 [0..103] [1051..53]

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Predicted Domain #1
Region A:
Residues: [1-843]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITRLSGACL RRSGAKRNWP REHLVHRSLL ASFSTTQRVL KCSVGPFRTS NVVFKSKEPK  60
   61 DNKPLDNKND PKKTHNEDES HTNESLPSTD KKKKKDNDDF KQNLKSSSNK TEEKYSATQA 120
  121 SKSKNDEFEL GGEENEDEMP LNGEFNKNVP AKYSVPDVYP QLLALPIARR PLFPGFYKAI 180
  181 VTKNPSVSEA IKELIKKRQP YIGAFLLKDE NTDTDVITNI DQVYPVGVFA QITSIFPAKS 240
  241 GSEPALTAVL YPHRRIRITE LIPPKEDADS AASSDAAELE TDKSSNLSSN GEVKSDLKQD 300
  301 NGKEEPEKEV ESTPSILQNF KVSLVNVENV PNEPFKRQDP VIKAVTSEIM NVFKDIANVS 360
  361 PLFREQIANF SISQTSGNVF DEPAKLADFA AAVSAADHRE LQEVLEATNI GDRLQKALYV 420
  421 LKKELLNAQL QHKINKEIEQ KITQRHKEYL LTEQLKQIKR ELGQELDSKE ALVTEFKKRT 480
  481 ESLSMPDHVK KVFNDELSKF QHLEPMAAEF NITRNYLDWI TQLPWGKRSV ENFDLDHAKE 540
  541 VLDRDHYGLK DVKDRVLELV AVGKLRGTMQ GKIMCLVGPP GVGKTSVGKS IASALNREFF 600
  601 RFSVGGLTDV AEIKGHRRTY IGAMPGKIVQ ALKKVQTENP LILIDEIDKV GKSHQGDPAS 660
  661 ALLELLDSEQ NSAFLDYYMD IPLDVSSVLF VCTANTIDTI PPPLLDRMEV IELSGYVSAE 720
  721 KVNIAKGYLI PQAKAACGLK DANVNISDDA IKGLISYYAH ESGVRNLKKS IEKIFRKTSF 780
  781 SIVKEIDDEL NSKEKSTGKS GKKTSPQSSE DAANKEASSV PLKVPDKVNI EIEEKDLTKY 840
  841 LGP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 112.0
Match: 1qvrA
Description: Crystal Structure Analysis of ClpB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrogen ion transmembrane transporter activity 3.92757313803074 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 3.76622182173583 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 3.49412822840068 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.46458392648207 bayes_pls_golite062009
substrate-specific transporter activity 3.411171656739 bayes_pls_golite062009
ion transmembrane transporter activity 3.09072076169796 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 2.99135301692379 bayes_pls_golite062009
cation transmembrane transporter activity 2.92624263342912 bayes_pls_golite062009
hydrolase activity 2.18454736627863 bayes_pls_golite062009
binding 2.0681607836408 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.84050240798436 bayes_pls_golite062009
pyrophosphatase activity 1.81138802583782 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.78927528875848 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.78903889318615 bayes_pls_golite062009
helicase activity 1.40781177352978 bayes_pls_golite062009
ATPase activity 1.18431260772292 bayes_pls_golite062009
DNA-dependent ATPase activity 1.09000822067541 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
DNA helicase activity 0.86836375892673 bayes_pls_golite062009
purine nucleotide binding 0.569910969126728 bayes_pls_golite062009
purine ribonucleotide binding 0.568840867400671 bayes_pls_golite062009
ribonucleotide binding 0.568779924702229 bayes_pls_golite062009
nucleotide binding 0.564275755355315 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.5607032154839 bayes_pls_golite062009
ATP-dependent helicase activity 0.5607032154839 bayes_pls_golite062009
motor activity 0.50661339105747 bayes_pls_golite062009
nucleic acid binding 0.503971340374059 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.384988511775694 bayes_pls_golite062009
protein binding 0.193768631623192 bayes_pls_golite062009
ATP binding 0.1860481660648 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.175442402308287 bayes_pls_golite062009
adenyl ribonucleotide binding 0.152859582615242 bayes_pls_golite062009
adenyl nucleotide binding 0.138615225841109 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.133736530545575 bayes_pls_golite062009
DNA binding 0.111331583742205 bayes_pls_golite062009
structure-specific DNA binding 0.0700789521444061 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [844-1067]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PIYTSQRLYD TTPPGVVMGL GWTPMGGVSM YVETIVKNIL SSNSTPSLER TGQLGDVMKE  60
   61 SSEISYSFSK SFLSKHFPNN KFFEHARLHM HCPEGSISKD GPSAGITMAT SLLSLALDTP 120
  121 VPATTAMTGE LTLTGKILRI GGLREKTVAA KLSGMKEILF PKSNLADWEQ LPDYVKEGLT 180
  181 GVPVAWYDDV FKRVFSNIDA EKCNNLWPNL IKSSSKQHQI SPSH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.30103
Match: 1rr9A
Description: Catalytic domain of E.coli Lon protease
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
mitochondrial heavy strand promoter sense binding 7.07169438832198 bayes_pls_golite062009
DNA polymerase binding 7.07169438832198 bayes_pls_golite062009
mitochondrial light strand promoter anti-sense binding 7.07169438832198 bayes_pls_golite062009
mitochondrial heavy strand promoter anti-sense binding 7.07169438832198 bayes_pls_golite062009
mitochondrial light strand promoter sense binding 7.07169438832198 bayes_pls_golite062009
ribonuclease activity 2.03745175432755 bayes_pls_golite062009
structural constituent of ribosome 1.38482286547386 bayes_pls_golite062009
hydrolase activity 1.18773479836745 bayes_pls_golite062009
3'-5'-exoribonuclease activity 1.16726450662143 bayes_pls_golite062009
exoribonuclease activity 1.1604717842042 bayes_pls_golite062009
structural molecule activity 1.14918348313691 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 1.13566902804592 bayes_pls_golite062009
ATP-dependent peptidase activity 0.99253423929971 bayes_pls_golite062009
binding 0.923114523007774 bayes_pls_golite062009
catalytic activity 0.878454819018611 bayes_pls_golite062009
peptidase activity 0.46678532223973 bayes_pls_golite062009
nuclease activity 0.315907493060144 bayes_pls_golite062009
endopeptidase activity 0.227419965943609 bayes_pls_golite062009
protein binding 0.214066724623027 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.161393552073973 bayes_pls_golite062009
nucleic acid binding 0.145830549540622 bayes_pls_golite062009
exonuclease activity 0.118186133308559 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.114504249104206 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.0709817198603016 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 6.9430052008157E-5 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle