YRC Public Data Repository - Protein Structure Prediction

Protein:	klp3
Organism:	Schizosaccharomyces pombe
Length:	554 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for klp3.

Description	E-value	Query Range	Subject Range
gi\|6502956 - gi\|6502956\|gb\|AAF14525.1\|AF154055_1 kinesin-like protein Klp3 [Schizosaccharomyces pombe]	331.0	[0..1]	[554..1]
gi\|17942987 - gi\|17942987\|pdb\|1GOJ\|A Chain A, Structure Of A Fast Kinesin: Implications For Atpase Mechanism And I...	309.0	[0..3]	[350..7]
gi\|29421252 - gi\|29421252\|gb\|AAO59288.1\| kinesin [Cochliobolus heterostrophus]	303.0	[0..6]	[552..19]
gi\|85112919 - gi\|85112919\|ref\|XP_964432.1\| KINESIN HEAVY CHAIN [Neurospora crassa OR74A] gi\|32419873, gi\|... - gi\|32419873\|ref\|XP_330380.1\| KINESIN HEAVY CHAIN [Neurospora crassa], gi\|28926214\|gb\|EAA35196.1\| KIN...	299.0	[0..3]	[530..7]
osm-3 - status:Confirmed UniProt:P46873 protein_id:AAM97997.1	298.0	[0..2]	[551..3]
gi\|38110379, gi\|... - gi\|39952229\|ref\|XP_363831.1\| hypothetical protein MG01757.4 [Magnaporthe grisea 70-15], gb\|EAA56106....	295.0	[0..3]	[552..6]
gi\|114554500 - gi\|114554500\|ref\|XP_513170.2\| PREDICTED: kinesin family member 17 [Pan troglodytes]	293.0	[0..2]	[451..199]
gi\|33877076, gi\|... - gi\|33877076\|gb\|AAH02721.1\| KIF5C protein [Homo sapiens], gi\|116283562\|gb\|AAH25961.1\| KIF5C protein [...	293.0	[0..3]	[327..8]
gi\|63101775 - gi\|63101775\|gb\|AAH95088.1\| LOC553428 protein [Danio rerio]	292.0	[0..3]	[340..9]

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Predicted Domain #1

Region A:
Residues: [1-344]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSIKVVCRI RPTNQLEQDL GGNNVIYPLN DSTVHIETSD YSGNFVFDRV FHPSSTQNDI  60
   61 FSYSIESTVD DLFLGYNGTV LAYGQTGSGK TYTMMGIENN FEKEGMTPRM LRRIFDKIRD 120
  121 SPSTTEYEVK VSYMEIYMEK IHDLLSEKND RLTVHEDKLQ GVYVQGLKTI YVSSETEALD 180
  181 ILNKGMGSRA VASTSMNAQS SRSHSIFVLE VVQTDTESGE TRRGRLFLVD LAGSESVGKS 240
  241 GAVGQTLEEA KKINRSLSTL GMVINSLTDS KLSHVPYRDS KLTRILKESL GGNSRTTLII 300
  301 NCSPDSYNAT ETLSTLRFGH RAKSIKNKAV VNSELSVDEM KRQL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	84.0
Match:	1gojA
Description:	Kinesin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
microtubule motor activity	7.68336791348661	bayes_pls_golite062009
plus-end-directed microtubule motor activity	4.97507344344589	bayes_pls_golite062009
microfilament motor activity	4.176620576177	bayes_pls_golite062009
motor activity	4.04927796049806	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
actin-dependent ATPase activity	2.77140616759165	bayes_pls_golite062009
microtubule plus-end binding	2.71138928021716	bayes_pls_golite062009
tubulin binding	2.67743463093593	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
microtubule binding	2.59155206524122	bayes_pls_golite062009
transporter activity	2.58140740499725	bayes_pls_golite062009
cytoskeletal protein binding	2.4101693596493	bayes_pls_golite062009
transmembrane transporter activity	2.39695871109024	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
ATPase activity, coupled	2.18396165590908	bayes_pls_golite062009
ATP-dependent DNA helicase activity	2.07967285635739	bayes_pls_golite062009
actin binding	1.75397031486306	bayes_pls_golite062009
hydrolase activity	1.57549510726226	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.40384549325664	bayes_pls_golite062009
helicase activity	1.33212695797068	bayes_pls_golite062009
substrate-specific transporter activity	1.29730375126024	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
DNA-dependent ATPase activity	1.07479235523606	bayes_pls_golite062009
purine nucleotide binding	0.929901285538132	bayes_pls_golite062009
nucleotide binding	0.922442819194247	bayes_pls_golite062009
purine ribonucleotide binding	0.920987930180051	bayes_pls_golite062009
ribonucleotide binding	0.920926158369519	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.906554174337376	bayes_pls_golite062009
nucleic acid binding	0.777787753097919	bayes_pls_golite062009
actin filament binding	0.728264616959762	bayes_pls_golite062009
guanyl nucleotide binding	0.640772201693186	bayes_pls_golite062009
guanyl ribonucleotide binding	0.63468044350616	bayes_pls_golite062009
GTP binding	0.621689261700018	bayes_pls_golite062009
structure-specific DNA binding	0.579644950922817	bayes_pls_golite062009
kinetochore binding	0.505370954958131	bayes_pls_golite062009
protein transporter activity	0.498432226280822	bayes_pls_golite062009
DNA binding	0.479412476059825	bayes_pls_golite062009
GTPase activity	0.437665353870877	bayes_pls_golite062009
active transmembrane transporter activity	0.434775387083003	bayes_pls_golite062009
ATP binding	0.41092997612902	bayes_pls_golite062009
adenyl ribonucleotide binding	0.385813421701492	bayes_pls_golite062009
adenyl nucleotide binding	0.377870145186619	bayes_pls_golite062009
ion transmembrane transporter activity	0.355466224802969	bayes_pls_golite062009
RNA helicase activity	0.34746349346164	bayes_pls_golite062009
histone acetyltransferase activity	0.328186246219424	bayes_pls_golite062009
lysine N-acetyltransferase activity	0.328186246219424	bayes_pls_golite062009
transcription regulator activity	0.312171320541728	bayes_pls_golite062009
ATP-dependent RNA helicase activity	0.30832907234141	bayes_pls_golite062009
RNA-dependent ATPase activity	0.29532978396745	bayes_pls_golite062009
primary active transmembrane transporter activity	0.294474570607914	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.282352478532746	bayes_pls_golite062009
ATP-dependent helicase activity	0.25143870859482	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.25143870859482	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.220608508617331	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.219533217661421	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.219157471322311	bayes_pls_golite062009
DNA helicase activity	0.17029946873911	bayes_pls_golite062009
mismatched DNA binding	0.13866566261611	bayes_pls_golite062009
minus-end-directed microtubule motor activity	0.068779631341469	bayes_pls_golite062009
cation transmembrane transporter activity	0.0254369227200564	bayes_pls_golite062009
structural constituent of cytoskeleton	0.0111338193708552	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [345-554]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YIYKDALSRC VCGARINNNL DYNNCHSNVW SGEHSLTLSN LAEKSNLKEA EIIQGNRTIQ  60
   61 ESNNDRDEST VASIHRHNFD SDSINRLYAE AQLELKQRDG VLSSTKQQLS DLMTALGDAQ 120
  121 ERYVELVKNH RVNSNLTANN SLNDKPGFTI EQKDKNFSIN NERNNFLQKL STLDSSLAAL 180
  181 VNVQRKLIKA LISKERPQNG TVIKKIQGGT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.0
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: