YRC Public Data Repository - Protein Structure Prediction

Protein:	cki1
Organism:	Schizosaccharomyces pombe
Length:	446 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cki1.

Description	E-value	Query Range	Subject Range
gi\|459190, gi\|10... - gi\|459190\|gb\|AAA19019.1\| casein kinase-1 [Schizosaccharomyces pombe], pir\|\|A53581 casein kinase 1 ho...	308.0	[0..1]	[446..1]
gi\|125543425 - gi\|125543425\|gb\|EAY89564.1\| hypothetical protein OsI_11096 [Oryza sativa Indica Group] gi\|28201244, gi\|... - gi\|28201244\|dbj\|BAC56590.1\| SnRK1b protein kinase [Oryza sativa Japonica Group], gi\|169244479\|gb\|ACA... gi\|4107007, gi\|4... - gi\|4107007\|dbj\|BAA36297.1\| OSK3 [Oryza sativa], gi\|4107003\|dbj\|BAA36295.1\| OSK5 [Oryza sativa]	262.0	[0..9]	[413..14]
gi\|15241748, gi\|... - gi\|15241748\|ref\|NP_198760.1\| SnRK1.3 (SNF1-RELATED PROTEIN KINASE 1.3); ATP binding / kinase/ protei...	262.0	[0..2]	[367..9]
gi\|73952971 - gi\|73952971\|ref\|XP_546168.2\| PREDICTED: similar to calcium/calmodulin-dependent protein kinase II ga...	262.0	[0..6]	[427..8]
gi\|114595760 - gi\|114595760\|ref\|XP_517404.2\| PREDICTED: similar to calcium/calmodulin-dependent protein kinase II, ... gi\|70906479 - gi\|70906479\|ref\|NP_001020610.1\| calcium/calmodulin-dependent protein kinase II, delta isoform 1 [Mus...	260.0	[0..6]	[365..8]
gi\|149698444 - gi\|149698444\|ref\|XP_001502669.1\| PREDICTED: hypothetical protein [Equus caballus] gi\|90079369 - gi\|90079369\|dbj\|BAE89364.1\| unnamed protein product [Macaca fascicularis] IPI:IPI00967869.... - Uncharacterized protein OS=Homo sapiens GN=CAMK2D PE=4 SV=1, IPI:IPI00967869.1\|TREMBL:E9PBG7;Q4G1A8\|... gi\|109075456 - gi\|109075456\|ref\|XP_001095890.1\| PREDICTED: similar to calcium/calmodulin-dependent protein kinase I...	260.0	[0..6]	[365..8]
gi\|62857006 - gi\|62857006\|dbj\|BAD95888.1\| Ser/Thr protein kinase [Lotus japonicus]	260.0	[0..11]	[374..19]

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Predicted Domain #1

Region A:
Residues: [1-319]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGQNNVVGV HYKVGRRIGE GSFGVIFEGT NLLNNQQVAI KFEPRRSDAP QLRDEYRTYK  60
   61 LLAGCTGIPN VYYFGQEGLH NILVIDLLGP SLEDLLDLCG RKFSVKTVAM AAKQMLARVQ 120
  121 SIHEKSLVYR DIKPDNFLIG RPNSKNANMI YVVDFGMVKF YRDPVTKQHI PYREKKNLSG 180
  181 TARYMSINTH LGREQSRRDD LEALGHVFMY FLRGSLPWQG LKAATNKQKY ERIGEKKQST 240
  241 PLRELCAGFP EEFYKYMHYA RNLAFDATPD YDYLQGLFSK VLERLNTTED ENFDWNLLNN 300
  301 GKGWQSLKSR NAETENQRS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.69897
Match:	1csnA
Description:	BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
phosphoinositide 3-kinase binding	1.47162554695064	bayes_pls_golite062009
protein tyrosine kinase activity	1.3898059094397	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.38496328649031	bayes_pls_golite062009
transcription regulator activity	1.30988141770642	bayes_pls_golite062009
receptor signaling protein activity	1.27291233344322	bayes_pls_golite062009
protein binding	1.22565748038754	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
DNA binding	1.17130513163489	bayes_pls_golite062009
nucleic acid binding	1.16049201286103	bayes_pls_golite062009
cytoskeletal protein binding	1.1208666000428	bayes_pls_golite062009
transcription factor activity	0.919430701010326	bayes_pls_golite062009
transmembrane receptor activity	0.913893847407112	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.821371946077904	bayes_pls_golite062009
receptor activity	0.775180603313375	bayes_pls_golite062009
transporter activity	0.595111702412257	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.499492353295369	bayes_pls_golite062009
tubulin binding	0.488928950975855	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
actin binding	0.464111806616899	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	0.461392047923247	bayes_pls_golite062009
transmembrane transporter activity	0.41384976209545	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
telethonin binding	0.366817170817532	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
signal transducer activity	0.270054246024761	bayes_pls_golite062009
molecular transducer activity	0.270054246024761	bayes_pls_golite062009
MAP kinase activity	0.26024936404169	bayes_pls_golite062009
microtubule binding	0.196718452862042	bayes_pls_golite062009
substrate-specific transporter activity	0.0922946791401962	bayes_pls_golite062009
protein kinase C activity	0.0795689006739899	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [320-446]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKPPAPKLES KSPALQNHAS TQNVVSKRSD YEKPFAEPHL NSASDSAEPN QNSLPNPPTE  60
   61 TKATTTVPDR SGLATNQPAP VDVHDSSEER VTREQVQNAT KETEAPKKKK SFWASILSCC 120
  121 SGSNEDT

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: