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View Structure Prediction Details

Protein: gi|114561117
Organism: Pan troglodytes
Length: 261 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|114561117.

Description E-value Query
Range		 Subject
Range
UCK2_MOUSE - Uridine-cytidine kinase 2 OS=Mus musculus GN=Uck2 PE=1 SV=1
UCK2_RAT - Uridine-cytidine kinase 2 OS=Rattus norvegicus GN=Uck2 PE=2 SV=2
 1.0E-76 [1..261] [1..261]
gi|76611769 - gi|76611769|ref|XP_614178.2| PREDICTED: similar to uridine-cytidine kinase 2 [Bos taurus]
 7.0E-75 [4..261] [221..478]
gi|156151450, gi... - gi|156151450|ref|NP_001095878.1| uridine-cytidine kinase 2 [Rattus norvegicus], gi|109498163|ref|XP_...
 5.0E-71 [1..261] [1..261]
gi|48425793, gi|... - gi|48425800|pdb|1UJ2|B Chain B, Crystal Structure Of Human Uridine-Cytidine Kinase 2 Complexed With ...
 7.0E-71 [1..250] [3..252]
UCK2A_DANRE - Uridine-cytidine kinase 2-A OS=Danio rerio GN=uck2a PE=2 SV=1
 3.0E-67 [1..261] [1..261]
gi|47215953 - gi|47215953|emb|CAF96355.1| unnamed protein product [Tetraodon nigroviridis]
 2.0E-66 [1..261] [1..262]

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Predicted Domain #1
Region A:
Residues: [1-261] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGDSEQTLQ NHQQPNGGEP FLIGVSGGTA SGKSSVCAKI VQLLGQNEVD YRQKQVVILS  60
   61 QDSFYRVLTS EQKAKALKGQ FNFDHPDAFD NELILKTLKE ITEGKTVQIP VYDFVSHSRK 120
  121 EETVTVYPAD VVLFEGILAF YSQEVRDLFQ MKLFVDTDAD TRLSRRVLRD ISERGRDLEQ 180
  181 ILSQYITFVK PAFEEFCLPT KKYADVIIPR GADNLVAINL IVQHIQDILN GGPSKRQTNG 240
  241 CLNGYTPSRK RQASESSSRP H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.522879
Match: 1xrjA
Description: Rapid structure determination of human uridine-cytidine kinase 2 using a conventional laboratory X-ray source and a single samarium derivative
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleobase, nucleoside, nucleotide kinase activity 3.66392587433723 bayes_pls_golite062009
binding 2.4974940028864 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.28726855139279 bayes_pls_golite062009
nucleotide kinase activity 2.24094813695083 bayes_pls_golite062009
pyrophosphatase activity 2.23754609668547 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.21702600128327 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.21503003850174 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 1.96697952975573 bayes_pls_golite062009
ATPase activity 1.70670922135201 bayes_pls_golite062009
nucleic acid binding 1.60768715809391 bayes_pls_golite062009
hydrolase activity 1.20846280768115 bayes_pls_golite062009
DNA binding 1.11699929651302 bayes_pls_golite062009
ATPase activity, coupled 1.02588328213159 bayes_pls_golite062009
RNA helicase activity 1.02424782546779 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription regulator activity 0.989226939888218 bayes_pls_golite062009
ATP binding 0.98146619596929 bayes_pls_golite062009
RNA-dependent ATPase activity 0.95986988363392 bayes_pls_golite062009
adenyl ribonucleotide binding 0.949788783884952 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.94128341275411 bayes_pls_golite062009
adenyl nucleotide binding 0.931486373329219 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
GTPase activity 0.768815888267067 bayes_pls_golite062009
small conjugating protein ligase activity 0.76790260478583 bayes_pls_golite062009
kinase activity 0.691112783105676 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.552505397412384 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.499834566483656 bayes_pls_golite062009
substrate-specific transporter activity 0.464456497491373 bayes_pls_golite062009
adenylate kinase activity 0.447752711852745 bayes_pls_golite062009
active transmembrane transporter activity 0.434775387083003 bayes_pls_golite062009
transporter activity 0.39890191703346 bayes_pls_golite062009
protein binding 0.378225828131122 bayes_pls_golite062009
primary active transmembrane transporter activity 0.294474570607914 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.282352478532746 bayes_pls_golite062009
acid-amino acid ligase activity 0.252249285455578 bayes_pls_golite062009
transmembrane transporter activity 0.22939561735194 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.220608508617331 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.219533217661421 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.219157471322311 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.0756212238097211 bayes_pls_golite062009
transcription factor activity 0.0434163635422169 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.0430764033739892 bayes_pls_golite062009
protein kinase activity 0.0364322017534667 bayes_pls_golite062009
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