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View Structure Prediction Details

Protein: gi|26996622
Organism: Homo sapiens
Length: 675 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|26996622.

Description E-value Query
Range		 Subject
Range
gi|38173782 - gi|38173782|gb|AAH60781.1| RHOT1 protein [Homo sapiens]
 0.0 [1..675] [23..697]
MIRO1_BOVIN - Mitochondrial Rho GTPase 1 OS=Bos taurus GN=RHOT1 PE=2 SV=1
 0.0 [45..675] [1..631]
gi|73966876 - gi|73966876|ref|XP_867966.1| PREDICTED: similar to mitochondrial Rho 1 isoform 2 [Canis familiaris]
 0.0 [45..675] [1..631]
MIRO1_MOUSE - Mitochondrial Rho GTPase 1 OS=Mus musculus GN=Rhot1 PE=1 SV=1
 0.0 [45..675] [1..631]
gi|109114064 - gi|109114064|ref|XP_001109912.1| PREDICTED: similar to ras homolog gene family, member T1 isoform 1 ...
 0.0 [3..638] [85..720]
MIRO1_DANRE - Mitochondrial Rho GTPase 1-A OS=Danio rerio GN=rhot1a PE=2 SV=1
 0.0 [58..675] [1..619]

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Predicted Domain #1
Region A:
Residues: [1-255] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRSWRCPGSL AGKQLRGRRG GPRRPKRLAG GAVGWVLLVR GVHSVRAGGG RPPRAADMKK  60
   61 DVRILLVGEP RVGKTSLIMS LVSEEFPEEV PPRAEEITIP ADVTPERVPT HIVDYSEAEQ 120
  121 SDEQLHQEIS QANVICIVYA VNNKHSIDKV TSRWIPLINE RTDKDSRLPL ILVGNKSDLV 180
  181 EYSSMETILP IMNQYTEIET CVECSAKNLK NISELFYYAQ KAVLHPTGPL YCPEEKEMKP 240
  241 ACIKALTRIF KISDQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.09691
Match: 2bcgY
Description: Structure of doubly prenylated Ypt1:GDI complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule motor activity 5.18272645402624 bayes_pls_golite062009
microfilament motor activity 3.88223640822153 bayes_pls_golite062009
motor activity 3.73454248797903 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.89122312915795 bayes_pls_golite062009
pyrophosphatase activity 2.81593838944939 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.79724985811732 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.79347973548337 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
actin-dependent ATPase activity 2.48415758556089 bayes_pls_golite062009
ATPase activity 2.44176688200537 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
actin binding 2.2973522188675 bayes_pls_golite062009
tubulin binding 1.92557767696163 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
microtubule binding 1.84561785126784 bayes_pls_golite062009
plus-end-directed microtubule motor activity 1.8063519626342 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.56325751172863 bayes_pls_golite062009
hydrolase activity 1.40217504818333 bayes_pls_golite062009
actin filament binding 1.28204719195916 bayes_pls_golite062009
GTPase activity 1.23010905798386 bayes_pls_golite062009
signal transducer activity 1.13474466330485 bayes_pls_golite062009
molecular transducer activity 1.13474466330485 bayes_pls_golite062009
protein transporter activity 1.05248757342537 bayes_pls_golite062009
ion transmembrane transporter activity 0.977237423302079 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
helicase activity 0.86140695609019 bayes_pls_golite062009
nucleic acid binding 0.777787753097919 bayes_pls_golite062009
structure-specific DNA binding 0.762584163889896 bayes_pls_golite062009
DNA-dependent ATPase activity 0.75383985982414 bayes_pls_golite062009
cation transmembrane transporter activity 0.557919489256916 bayes_pls_golite062009
double-stranded DNA binding 0.49000746592281 bayes_pls_golite062009
DNA binding 0.479412476059825 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
receptor activity 0.381142123108547 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
transmembrane receptor activity 0.355770151889237 bayes_pls_golite062009
RNA helicase activity 0.34746349346164 bayes_pls_golite062009
transcription regulator activity 0.312171320541728 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.30832907234141 bayes_pls_golite062009
RNA-dependent ATPase activity 0.29532978396745 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.28297830193871 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.28297830193871 bayes_pls_golite062009
ATP-dependent helicase activity 0.25143870859482 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.25143870859482 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 0.213018989352421 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.123304946374679 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.0775601177068852 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [256-332] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNDGTLNDAE LNFFQRICFN TPLAPQALED VKNVVRKHIS DGVADSGLTL KGFLFLHTLF  60
   61 IQRGRHETTW TVLRRFG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.806 N/A N/A a.39.1 EF-hand

Predicted Domain #3
Region A:
Residues: [333-675] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDDDLDLTPE YLFPLLKIPP DCTTELNHHA YLFLQSTFDK HDLDRDCALS PDELKDLFKV  60
   61 FPYIPWGPDV NNTVCTNERG WITYQGFLSQ WTLTTYLDVQ RCLEYLGYLG YSILTEQESQ 120
  121 ASAVTVTRDK KIDLQKKQTQ RNVFRCNVIG VKNCGKSGVL QALLGRNLMR QKKIREDHKS 180
  181 YYAINTVYVY GQEKYLLLHD ISESEFLTEA EIICDVVCLV YDVSNPKSFE YCARIFKQHF 240
  241 MDSRIPCLIV AAKSDLHEVK QEYSISPTDF CRKHKMPPPQ AFTCNTADAP SKDIFVKLTT 300
  301 MAMYPHVTQA DLKSSTFWLR ASFGATVFAV LGFAMYKALL KQR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.39794
Match: 1xzpA
Description: Structure of the GTP-binding protein TrmE from Thermotoga maritima
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule motor activity 5.18272645402624 bayes_pls_golite062009
microfilament motor activity 3.88223640822153 bayes_pls_golite062009
motor activity 3.73454248797903 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.89122312915795 bayes_pls_golite062009
pyrophosphatase activity 2.81593838944939 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.79724985811732 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.79347973548337 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
actin-dependent ATPase activity 2.48415758556089 bayes_pls_golite062009
ATPase activity 2.44176688200537 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
actin binding 2.2973522188675 bayes_pls_golite062009
tubulin binding 1.92557767696163 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
microtubule binding 1.84561785126784 bayes_pls_golite062009
plus-end-directed microtubule motor activity 1.8063519626342 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.56325751172863 bayes_pls_golite062009
hydrolase activity 1.40217504818333 bayes_pls_golite062009
actin filament binding 1.28204719195916 bayes_pls_golite062009
GTPase activity 1.23010905798386 bayes_pls_golite062009
signal transducer activity 1.13474466330485 bayes_pls_golite062009
molecular transducer activity 1.13474466330485 bayes_pls_golite062009
protein transporter activity 1.05248757342537 bayes_pls_golite062009
ion transmembrane transporter activity 0.977237423302079 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
helicase activity 0.86140695609019 bayes_pls_golite062009
nucleic acid binding 0.777787753097919 bayes_pls_golite062009
structure-specific DNA binding 0.762584163889896 bayes_pls_golite062009
DNA-dependent ATPase activity 0.75383985982414 bayes_pls_golite062009
cation transmembrane transporter activity 0.557919489256916 bayes_pls_golite062009
double-stranded DNA binding 0.49000746592281 bayes_pls_golite062009
DNA binding 0.479412476059825 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
receptor activity 0.381142123108547 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
transmembrane receptor activity 0.355770151889237 bayes_pls_golite062009
RNA helicase activity 0.34746349346164 bayes_pls_golite062009
transcription regulator activity 0.312171320541728 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.30832907234141 bayes_pls_golite062009
RNA-dependent ATPase activity 0.29532978396745 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.28297830193871 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.28297830193871 bayes_pls_golite062009
ATP-dependent helicase activity 0.25143870859482 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.25143870859482 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 0.213018989352421 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.123304946374679 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.0775601177068852 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle