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View Structure Prediction Details

Protein: KIF3B
Organism: Homo sapiens
Length: 747 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KIF3B.

Description E-value Query
Range		 Subject
Range
gi|27882435 - gi|27882435|gb|AAH44720.1| Kif3a protein [Mus musculus]
 9.0E-75 [3..371] [8..376]
gi|109469052 - gi|109469052|ref|XP_215883.4| PREDICTED: similar to Kinesin-like protein KIF3B (Microtubule plus end...
 1.0E-74 [1..420] [1..420]
gi|75773654 - gi|75773654|gb|AAI05210.1| KIF3A protein [Bos taurus]
 2.0E-73 [3..371] [8..376]
gi|68533113 - gi|68533113|dbj|BAE06111.1| KIF1A variant protein [Homo sapiens]
 2.0E-73 [9..664] [11..693]
gi|85861055 - gi|85861055|gb|ABC86477.1| IP03512p [Drosophila melanogaster]
 2.0E-72 [5..367] [16..379]
gi|478013, gi|300088 - pir||C48835 kinesin-like protein (clone XKlp3) Klp - African clawed frog (fragment), gi|300088|gb|AA...
 3.0E-70 [10..338] [1..329]

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Predicted Domain #1
Region A:
Residues: [1-208] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPKGTA HEMPKTFTFD  60
   61 AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT GKTYTMEGIR GDPEKRGVIP 120
  121 NSFDHIFTHI SRSQNQQYLV RASYLEIYQE EIRDLLSKDQ TKRLELKERP DTGVYVKDLS 180
  181 SFVTKSVKEI EHVMNVGNQN RSVGATNM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.154902
Match: 1gojA
Description: Kinesin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule motor activity 7.68336791348661 bayes_pls_golite062009
plus-end-directed microtubule motor activity 4.97507344344589 bayes_pls_golite062009
microfilament motor activity 4.176620576177 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
actin-dependent ATPase activity 2.77140616759165 bayes_pls_golite062009
microtubule plus-end binding 2.71138928021716 bayes_pls_golite062009
tubulin binding 2.67743463093593 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
microtubule binding 2.59155206524122 bayes_pls_golite062009
transporter activity 2.58140740499725 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
transmembrane transporter activity 2.39695871109024 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
ATPase activity, coupled 2.18396165590908 bayes_pls_golite062009
ATP-dependent DNA helicase activity 2.07967285635739 bayes_pls_golite062009
actin binding 1.75397031486306 bayes_pls_golite062009
hydrolase activity 1.57549510726226 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.40384549325664 bayes_pls_golite062009
helicase activity 1.33212695797068 bayes_pls_golite062009
substrate-specific transporter activity 1.29730375126024 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
DNA-dependent ATPase activity 1.07479235523606 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.906554174337376 bayes_pls_golite062009
nucleic acid binding 0.777787753097919 bayes_pls_golite062009
actin filament binding 0.728264616959762 bayes_pls_golite062009
beta-tubulin binding 0.654735466720932 bayes_pls_golite062009
structure-specific DNA binding 0.579644950922817 bayes_pls_golite062009
kinetochore binding 0.505370954958131 bayes_pls_golite062009
microtubule-severing ATPase activity 0.491769258942331 bayes_pls_golite062009
DNA binding 0.479412476059825 bayes_pls_golite062009
GTPase activity 0.437665353870877 bayes_pls_golite062009
active transmembrane transporter activity 0.434775387083003 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
ion transmembrane transporter activity 0.355466224802969 bayes_pls_golite062009
RNA helicase activity 0.34746349346164 bayes_pls_golite062009
lysine N-acetyltransferase activity 0.328186246219424 bayes_pls_golite062009
histone acetyltransferase activity 0.328186246219424 bayes_pls_golite062009
transcription regulator activity 0.312171320541728 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.30832907234141 bayes_pls_golite062009
RNA-dependent ATPase activity 0.29532978396745 bayes_pls_golite062009
primary active transmembrane transporter activity 0.294474570607914 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.282352478532746 bayes_pls_golite062009
ATP-dependent helicase activity 0.25143870859482 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.25143870859482 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.220608508617331 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.219533217661421 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.219157471322311 bayes_pls_golite062009
protein transporter activity 0.178442534411253 bayes_pls_golite062009
DNA helicase activity 0.17029946873911 bayes_pls_golite062009
mismatched DNA binding 0.13866566261611 bayes_pls_golite062009
alpha-tubulin binding 0.100557713995661 bayes_pls_golite062009
signal transducer activity 0.0766574932313888 bayes_pls_golite062009
molecular transducer activity 0.0766574932313888 bayes_pls_golite062009
minus-end-directed microtubule motor activity 0.068779631341469 bayes_pls_golite062009
cation transmembrane transporter activity 0.0254369227200564 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [209-256] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEHSSRSHAI FVITIECSEV GLDGENHIRV GKLNLVDLAG SERQAKTG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.17
Match: 1ii6A
Description: Kinesin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [257-388] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQGERLKEAT KINLSLSALG NVISALVDGK STHIPYRDSK LTRLLQDSLG GNAKTVMVAN  60
   61 VGPASYNVEE TLTTLRYANR AKNIKNKPRV NEDPKDALLR EFQEEIARLK AQLEKRSIGR 120
  121 RKRREKRREG GG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.522879
Match: 3kinB
Description: KINESIN (DIMERIC) FROM RATTUS NORVEGICUS
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [389-565] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGGGGEEEEE EGEEGEEEGD DKDDYWREQQ EKLEIEKRAI VEDHSLVAEE KMRLLKEKEK  60
   61 KMEDLRREKD AAEMLGAKIK AMESKLLVGG KNIVDHTNEQ QKILEQKRQE IAEQKRRERE 120
  121 IQQQMESRDE ETLELKETYS SLQQEVDIKT KKLKKLFSKL QAVKAEIHDL QEEHIKE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.24
Match: 1jchA
Description: Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [566-747] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQELEQTQNE LTRELKLKHL IIENFIPLEE KSKIMNRAFF DEEEDHWKLH PITRLENQQM  60
   61 MKRPVSAVGY KRPLSQHARM SMMIRPEARY RAENIVLLEL DMPSRTTRDY EGPAIAPKVQ 120
  121 AALDAALQDE DEIQVDASSF ESTANKKSKA RPKSGRKSGS SSSSSGTPAS QLYPQSRGLV 180
  181 PK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 2i1jA
Description: No description for 2i1jA was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle