| Protein: | BUB1 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 1021 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BUB1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..1021] | [1..1021] |
|
|
0.0 | [36..1020] | [48..1102] |
|
|
0.0 | [37..1020] | [5..1085] |
|
|
0.0 | [36..1020] | [4..1058] |
|
Region A: Residues: [1-136] |
1 11 21 31 41 51
| | | | | |
1 MNLDLGSTVR GYESDKDTFP QSKGVSSSQK EQHSQLNQTK IAYEQRLLND LEDMDDPLDL 60
61 FLDYMIWIST SYIEVDSESG QEVLRSTMER CLIYIQDMET YRNDPRFLKI WIWYINLFLS 120
121 NNFHESENTF KYMFNK
|
| Detection Method: |  |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.543 | a.1.1 | Globin-like |
| View | Download | 0.479 | a.26.1 | 4-helical cytokines |
| View | Download | 0.542 | a.61.1 | Retroviral matrix proteins |
| View | Download | 0.542 | a.118.9 | ENTH/VHS domain |
| View | Download | 0.522 | c.58.1 | Aminoacid dehydrogenase-like, N-terminal domain |
| View | Download | 0.477 | a.118.1 | ARM repeat |
| View | Download | 0.430 | a.39.2 | Insect pheromon/odorant-binding proteins |
| View | Download | 0.423 | a.85.1 | Hemocyanin, N-terminal domain |
| View | Download | 0.409 | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.405 | a.63.1 | Apolipophorin-III |
| View | Download | 0.402 | a.69.3 | 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain |
| View | Download | 0.394 | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.387 | a.118.8 | TPR-like |
| View | Download | 0.375 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.371 | d.110.4 | SNARE-like |
| View | Download | 0.362 | a.29.2 | Bromodomain |
| View | Download | 0.360 | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.355 | d.58.26 | GHMP Kinase, C-terminal domain |
| View | Download | 0.342 | a.118.8 | TPR-like |
| View | Download | 0.331 | a.80.1 | DNA polymerase III clamp loader subunits, C-terminal domain |
| View | Download | 0.330 | d.110.4 | SNARE-like |
| View | Download | 0.329 | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.326 | a.1.1 | Globin-like |
| View | Download | 0.315 | f.1.4 | Bcl-2 inhibitors of programmed cell death |
| View | Download | 0.313 | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.300 | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.291 | d.110.4 | SNARE-like |
| View | Download | 0.290 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.288 | a.78.1 | Fatty acid responsive transcription factor FadR, C-terminal domain |
| View | Download | 0.282 | d.68.1 | Translation initiation factor IF3, C-terminal domain |
| View | Download | 0.278 | a.25.2 | Thermoplasma ferritin-like 4-helical bundle |
| View | Download | 0.267 | d.58.29 | Adenylyl and guanylyl cyclase catalytic domain |
| View | Download | 0.266 | a.1.1 | Globin-like |
| View | Download | 0.263 | a.181.1 | Antibiotic binding domain of TipA-like multidrug resistance regulators |
| View | Download | 0.260 | d.58.26 | GHMP Kinase, C-terminal domain |
| View | Download | 0.251 | c.58.1 | Aminoacid dehydrogenase-like, N-terminal domain |
| View | Download | 0.249 | a.89.1 | Methyl-coenzyme M reductase alpha and beta chain C-terminal domain |
| View | Download | 0.246 | f.13.1 | Family A G protein-coupled receptor-like |
| View | Download | 0.245 | a.29.2 | Bromodomain |
| View | Download | 0.245 | a.121.1 | Tetracyclin repressor-like, C-terminal domain |
| View | Download | 0.244 | a.1.1 | Globin-like |
| View | Download | 0.243 | c.95.1 | Thiolase-like |
| View | Download | 0.242 | c.58.1 | Aminoacid dehydrogenase-like, N-terminal domain |
| View | Download | 0.234 | a.118.11 | Cytochrome c oxidase subunit E |
| View | Download | 0.234 | a.1.1 | Globin-like |
| View | Download | 0.223 | a.131.1 | Peridinin-chlorophyll protein |
| View | Download | 0.222 | d.15.6 | Superantigen toxins, C-terminal domain |
| View | Download | 0.222 | d.110.4 | SNARE-like |
| View | Download | 0.219 | a.1.1 | Globin-like |
| View | Download | 0.217 | a.39.1 | EF-hand |
| View | Download | 0.207 | b.34.8 | Fumarylacetoacetate hydrolase, FAH, N-terminal domain |
| View | Download | 0.206 | a.24.16 | Nucleotidyltransferase substrate binding subunit/domain |
| View | Download | 0.206 | d.110.4 | SNARE-like |
| View | Download | 0.204 | a.90.1 | Transcription factor STAT-4 N-domain |
| View | Download | 0.204 | a.126.1 | Serum albumin-like |
| View | Download | 0.204 | d.14.1 | Ribosomal protein S5 domain 2-like |
| View | Download | 0.201 | a.182.1 | GatB/YqeY domain |
| View | Download | 0.201 | a.41.1 | Domain of poly(ADP-ribose) polymerase |
| View | Download | 0.200 | a.4.1 | Homeodomain-like |
|
Region A: Residues: [137-211] |
1 11 21 31 41 51
| | | | | |
1 GIGTKLSLFY EEFSKLLENA QFFLEAKVLL ELGAENNCRP YNRLLRSLSN YEDRLREMNI 60
61 VENQNSVPDS RERLK
|
| Detection Method: | |
| Confidence: | 3.69897 |
| Match: | 1cxzB_ |
| Description: | Effector domain of the protein kinase pkn/prk1 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| transcription regulator activity | 3.69172569316336 | bayes_pls_golite062009 |
| DNA binding | 3.39869859972616 | bayes_pls_golite062009 |
| nucleic acid binding | 3.23848471176801 | bayes_pls_golite062009 |
| binding | 3.13193163173466 | bayes_pls_golite062009 |
| transcription factor activity | 2.84890910865229 | bayes_pls_golite062009 |
| transcription factor binding | 2.24654471792947 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 1.94402505264757 | bayes_pls_golite062009 |
| transcription activator activity | 1.7419016121428 | bayes_pls_golite062009 |
| protein binding | 1.73179783495389 | bayes_pls_golite062009 |
| kinase activity | 1.65716179379575 | bayes_pls_golite062009 |
| protein kinase activity | 1.65559891124729 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 1.49417707466137 | bayes_pls_golite062009 |
| protein heterodimerization activity | 1.3916255846493 | bayes_pls_golite062009 |
| transporter activity | 1.345463646363 | bayes_pls_golite062009 |
| protein dimerization activity | 1.3011414258578 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.25717484863319 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.23751270866642 | bayes_pls_golite062009 |
| voltage-gated cation channel activity | 1.2111783925162 | bayes_pls_golite062009 |
| transmembrane transporter activity | 1.1928367617123 | bayes_pls_golite062009 |
| transcription repressor activity | 1.16489293306631 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 1.10368550509667 | bayes_pls_golite062009 |
| voltage-gated potassium channel activity | 1.09066951584628 | bayes_pls_golite062009 |
| voltage-gated ion channel activity | 1.0878469536455 | bayes_pls_golite062009 |
| voltage-gated channel activity | 1.08700038835943 | bayes_pls_golite062009 |
| cation channel activity | 1.05127986997493 | bayes_pls_golite062009 |
| potassium channel activity | 1.00381478626553 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.9754275279592 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 0.97440822227802 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.97238321935796 | bayes_pls_golite062009 |
| gated channel activity | 0.96773601513941 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 0.94560998710422 | bayes_pls_golite062009 |
| ion channel activity | 0.913028049156819 | bayes_pls_golite062009 |
| substrate-specific channel activity | 0.86162931627036 | bayes_pls_golite062009 |
| transcription coactivator activity | 0.85685043852877 | bayes_pls_golite062009 |
| passive transmembrane transporter activity | 0.84703861081342 | bayes_pls_golite062009 |
| channel activity | 0.84703861081342 | bayes_pls_golite062009 |
| histone acetyltransferase binding | 0.806615474344071 | bayes_pls_golite062009 |
| metal ion transmembrane transporter activity | 0.7482723372563 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity, enhancer binding | 0.63697280374462 | bayes_pls_golite062009 |
| transferase activity | 0.511065872472486 | bayes_pls_golite062009 |
|
Region A: Residues: [212-452] |
1 11 21 31 41 51
| | | | | |
1 GRLIYRTAPF FIRKFLTSSL MTDDKENRAN LNSNVGVGKS APNVYQDSIV VADFKSETER 60
61 LNLNSSKQPS NQRLKNGNKK TSIYADQKQS NNPVYKLINT PGRKPERIVF NFNLIYPEND 120
121 EEFNTEEILA MIKGLYKVQR RGKKHTEDYT SDKNRKKRKL DVLVERRQDL PSSQPPVVPK 180
181 STRIEVFKDD DNPSQSTHHK NTQVQVQTTT SILPLKPVVD GNLAHETPVK PSLTSNASRS 240
241 P
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [453-589] |
1 11 21 31 41 51
| | | | | |
1 TVTAFSKDAI NEVFSMFNQH YSTPGALLDG DDTTTSKFNV FENFTQEFTA KNIEDLTEVK 60
61 DPKQETVSQQ TTSTNETNDR YERLSNSSTR PEKADYMTPI KETTETDVVP IIQTPKEQIR 120
121 TEDKKSGDNT ETQTQLT
|
| Detection Method: | |
| Confidence: | 11.0 |
| Match: | 1jnuA_ |
| Description: | Photoreceptor phy3 flavin-binding domain, lov2 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| transcription regulator activity | 3.69172569316336 | bayes_pls_golite062009 |
| DNA binding | 3.39869859972616 | bayes_pls_golite062009 |
| nucleic acid binding | 3.23848471176801 | bayes_pls_golite062009 |
| binding | 3.13193163173466 | bayes_pls_golite062009 |
| transcription factor activity | 2.84890910865229 | bayes_pls_golite062009 |
| transcription factor binding | 2.24654471792947 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 1.94402505264757 | bayes_pls_golite062009 |
| transcription activator activity | 1.7419016121428 | bayes_pls_golite062009 |
| protein binding | 1.73179783495389 | bayes_pls_golite062009 |
| kinase activity | 1.65716179379575 | bayes_pls_golite062009 |
| protein kinase activity | 1.65559891124729 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 1.49417707466137 | bayes_pls_golite062009 |
| protein heterodimerization activity | 1.3916255846493 | bayes_pls_golite062009 |
| transporter activity | 1.345463646363 | bayes_pls_golite062009 |
| protein dimerization activity | 1.3011414258578 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.25717484863319 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.23751270866642 | bayes_pls_golite062009 |
| voltage-gated cation channel activity | 1.2111783925162 | bayes_pls_golite062009 |
| transmembrane transporter activity | 1.1928367617123 | bayes_pls_golite062009 |
| transcription repressor activity | 1.16489293306631 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 1.10368550509667 | bayes_pls_golite062009 |
| voltage-gated potassium channel activity | 1.09066951584628 | bayes_pls_golite062009 |
| voltage-gated ion channel activity | 1.0878469536455 | bayes_pls_golite062009 |
| voltage-gated channel activity | 1.08700038835943 | bayes_pls_golite062009 |
| cation channel activity | 1.05127986997493 | bayes_pls_golite062009 |
| potassium channel activity | 1.00381478626553 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.9754275279592 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 0.97440822227802 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.97238321935796 | bayes_pls_golite062009 |
| gated channel activity | 0.96773601513941 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 0.94560998710422 | bayes_pls_golite062009 |
| ion channel activity | 0.913028049156819 | bayes_pls_golite062009 |
| substrate-specific channel activity | 0.86162931627036 | bayes_pls_golite062009 |
| transcription coactivator activity | 0.85685043852877 | bayes_pls_golite062009 |
| passive transmembrane transporter activity | 0.84703861081342 | bayes_pls_golite062009 |
| channel activity | 0.84703861081342 | bayes_pls_golite062009 |
| histone acetyltransferase binding | 0.806615474344071 | bayes_pls_golite062009 |
| metal ion transmembrane transporter activity | 0.7482723372563 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity, enhancer binding | 0.63697280374462 | bayes_pls_golite062009 |
| transferase activity | 0.511065872472486 | bayes_pls_golite062009 |
|
Region A: Residues: [590-663] |
1 11 21 31 41 51
| | | | | |
1 STTIQSSPFL TQPEPQAEKL LQTAEHSEKS KEHYPTIIPP FTKIKNQPPV IIENPLSNNL 60
61 RAKFLSEISP PLFQ
|
| Detection Method: | |
| Confidence: | 6.221849 |
| Match: | 1a25A_ |
| Description: | C2 domain from protein kinase c (beta) |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [664-691] |
1 11 21 31 41 51
| | | | | |
1 YNTFYNYNQE LKMSSLLKKI HRVSRNEN
|
|
Region B: Residues: [751-770] |
1 11 21 31 41 51
| | | | | |
1 FRLRKSTILK SIINASALHL
|
|
Region C: Residues: [781-1021] |
1 11 21 31 41 51
| | | | | |
1 YASQGTVLDL INLQREKAID GNGIMDEYLC MFITVELMKV LEKIHEVGII HGDLKPDNCM 60
61 IRLEKPGEPL GAHYMRNGED GWENKGIYLI DFGRSFDMTL LPPGTKFKSN WKADQQDCWE 120
121 MRAGKPWSYE ADYYGLAGVI HSMLFGKFIE TIQLQNGRCK LKNPFKRYWK KEIWGVIFDL 180
181 LLNSGQASNQ ALPMTEKIVE IRNLIESHLE QHAENHLRNV ILSIEEELSH FQYKGKPSRR 240
241 F
|
| Detection Method: | |
| Confidence: | 105.0 |
| Match: | 1ctpE_ |
| Description: | cAMP-dependent PK, catalytic subunit |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [692-750] |
1 11 21 31 41 51
| | | | | |
1 KNPIVDFKKT GDLYCIRGEL GEGGYATVYL AESSQGHLRA LKVEKPASVW EYYIMSQVE
|
|
Region B: Residues: [771-780] |
1 11 21 31 41 51
| | | | | |
1 FLDESYLVLN
|
| Detection Method: | |
| Confidence: | 105.0 |
| Match: | 1ctpE_ |
| Description: | cAMP-dependent PK, catalytic subunit |
| Matching Structure (courtesy of the PDB): |
|
