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View Structure Prediction Details

Protein: RCK1
Organism: Saccharomyces cerevisiae
Length: 512 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RCK1.

Description E-value Query
Range
Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [3..506] [6..457]
RCK1_YEAST - Serine/threonine-protein kinase RCK1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RCK...
RCK1 - Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe ce...
0.0 [1..512] [1..512]
gi|15289758 - gi|15289758|dbj|BAB63463.1| calcium dependent protein kinase [Solanum tuberosum]
0.0 [3..506] [6..461]
gi|16215467 - gi|16215467|emb|CAC82998.1| calcium-dependent protein kinase 2 [Nicotiana tabacum]
0.0 [3..506] [6..464]
gi|16215475 - gi|16215475|emb|CAC83000.1| calcium-dependent protein kinase 2 [Nicotiana benthamiana]
0.0 [3..506] [6..464]
CDPKL_ARATH - Calcium-dependent protein kinase 21 OS=Arabidopsis thaliana GN=CPK21 PE=1 SV=1
0.0 [49..506] [1..426]

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Predicted Domain #1
Region A:
Residues: [1-94]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVNPEFIAD GIDFYPTTPD AAYFNAADGK NKVNRINGNS ENLHHSFASG CRRSSLSVDF  60
   61 NVTSSDSEKS EQSCLENNSQ EDEYFCDIFS TELK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.503 d.42.1 POZ domain
View Download 0.608 a.28.1 ACP-like
View Download 0.604 a.61.1 Retroviral matrix proteins
View Download 0.648 d.79.3 L30e-like
View Download 0.565 d.203.1 DsrC, the gamma subunit of dissimilatory sulfite reductase
View Download 0.474 b.6.1 Cupredoxins
View Download 0.427 a.59.1 PAH2 domain
View Download 0.399 d.95.2 Homing endonucleases
View Download 0.380 a.150.1 Anti-sigma factor AsiA
View Download 0.373 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.371 d.79.3 L30e-like
View Download 0.360 c.23.1 CheY-like
View Download 0.338 c.23.1 CheY-like
View Download 0.335 a.4.5 "Winged helix" DNA-binding domain
View Download 0.323 a.60.13 Putative methyltransferase TM0872, insert domain
View Download 0.313 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.311 d.68.3 SirA-like
View Download 0.309 d.58.7 RNA-binding domain, RBD
View Download 0.283 d.56.1 GroEL-intermediate domain like
View Download 0.283 d.52.1 Alpha-lytic protease prodomain
View Download 0.281 c.44.2 Enzyme IIB-cellobiose
View Download 0.280 d.95.2 Homing endonucleases
View Download 0.277 a.60.1 SAM/Pointed domain
View Download 0.261 d.58.1 4Fe-4S ferredoxins
View Download 0.255 c.23.1 CheY-like
View Download 0.247 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.245 d.58.25 Killer toxin KP6 alpha-subunit
View Download 0.243 c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.241 c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.238 d.95.2 Homing endonucleases
View Download 0.237 d.58.5 GlnB-like
View Download 0.222 f.14.1 Voltage-gated potassium channels
View Download 0.221 a.74.1 Cyclin-like
View Download 0.220 d.58.7 RNA-binding domain, RBD
View Download 0.214 d.68.3 SirA-like
View Download 0.214 d.58.5 GlnB-like
View Download 0.212 c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.209 a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain
View Download 0.208 a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.202 c.3.1 FAD/NAD(P)-binding domain

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity 4.97855712164511 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cAMP-dependent protein kinase activity 4.66277812893755 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
calmodulin-dependent protein kinase activity 4.31938467136214 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
transmembrane receptor protein kinase activity 2.54265774272269 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 2.16831387024372 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
telethonin binding 1.59285057739948 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
transporter activity 1.07717671444596 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
transmembrane transporter activity 0.93867354225509 bayes_pls_golite062009
sequence-specific DNA binding 0.925299895386908 bayes_pls_golite062009
growth factor binding 0.86076618871384 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
alpha-actinin binding 0.713064190387634 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
substrate-specific transporter activity 0.419967454336647 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
phosphotyrosine binding 0.311079584914389 bayes_pls_golite062009
kinase binding 0.26752427107238 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.20643152368029 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.20643152368029 bayes_pls_golite062009
ErbB-2 class receptor binding 0.182469382556979 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.176810368721201 bayes_pls_golite062009
insulin receptor binding 0.09784832072622 bayes_pls_golite062009
MAP kinase activity 0.08504542461349 bayes_pls_golite062009
protein kinase binding 0.00674998152095019 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [95-218]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDETSNKSTD YSSSNHQYPE QLELHNYKLL NKIGEGAFSR VFKAVGINTD DQAPVAIKAI  60
   61 IKKGISSDAI LKGNDRIQGS SRKKVLNEVA IHKLVSKNNP HCTKFIAFQE SANYYYLVTE 120
  121 LVTG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [442-457]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RAETLHCALS CQSEKQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 623.228787
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [219-441]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEIFDRIVQL TCFSEDLARH VITQVAIAIK HMHYMGIVHR DVKPENLLFE PIPFYGLDGD  60
   61 MQKEDEFTLG VGGGGIGLVK LMDFGLAKKL RNNTAKTPCG TIEYVASEVF TSKRYSMKVD 120
  121 MWSIGCVLFT LLCGYPPFYE KNEKTLLKKI SRGDYEFLAP WWDNISSGAK NAVTHLLEVD 180
  181 PNKRYDIDDF LNDPWLNSYD CLKDSNSNSY ASVQSILNDS FDE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 623.228787
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [458-512]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDTEFSRSES SEYIFMTEED RNLRGSWIGE PKECFTLDLA TSSIYRRRKN KIFFW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.154902
Match: 1lj6A_
Description: No description for 1lj6A_ was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle