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View Structure Prediction Details

Protein: AFG3
Organism: Saccharomyces cerevisiae
Length: 761 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AFG3.

Description E-value Query
Range		 Subject
Range
gi|541748 - gi|541748|emb|CAA54091.1| Afg3p [Saccharomyces cerevisiae]
 0.0 [1..761] [1..761]
AFG3L2 - AFG3 ATPase family gene 3-like 2 (yeast)
 0.0 [49..757] [77..773]
FTSHA_ARATH - ATP-dependent zinc metalloprotease FTSH 10, mitochondrial OS=Arabidopsis thaliana GN=FTSH10 PE=1 SV=...
 0.0 [24..740] [43..772]
gi|15021761 - gi|15021761|gb|AAK77908.1|AF397903_1 AAA-metalloprotease FtsH [Pisum sativum]
 0.0 [29..756] [42..789]
YTA12_SCHPO - Mitochondrial respiratory chain complexes assembly protein rca1 OS=Schizosaccharomyces pombe (strain...
SPBC543.09 - mitochondrial m-AAA protease
 0.0 [6..749] [33..752]
gi|15891238, gi|... - gi|15891238|ref|NP_356910.1| hypothetical protein AGR_L_2253 [Agrobacterium tumefaciens str. C58], g...
gi|25308068 - pir||E98271 metalloproteinase ftsH (AJ243808) [imported] - Agrobacterium tumefaciens (strain C58, Ce...
 0.0 [112..758] [15..639]

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Predicted Domain #1
Region A:
Residues: [1-210] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMMWQRYARG APRSLTSLSF GKASRISTVK PVLRSRMPVH QRLQTLSGLA TRNTIHRSTQ  60
   61 IRSFHISWTR LNENRPNKEG EGKNNGNKDN NSNKEDGKDK RNEFGSLSEY FRSKEFANTM 120
  121 FLTIGFTIIF TLLTPSSNNS GDDSNRVLTF QDFKTKYLEK GLVSKIYVVN KFLVEAELVN 180
  181 TKQVVSFTIG SVDIFEEQMD QIQDLLNIPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 516.9897
Match: 1e32A_
Description: Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [211-284] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDRIPIKYIE RSSPFTFLFP FLPTIILLGG LYFITRKINS SPPNANGGGG GGLGGMFNVG  60
   61 KSRAKLFNKE TDIK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 516.9897
Match: 1e32A_
Description: Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleoside-triphosphatase activity 1.66565132432505 bayes_pls_golite062009
hydrolase activity 1.62872031361523 bayes_pls_golite062009
pyrophosphatase activity 1.59966904665651 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.5827346030945 bayes_pls_golite062009
ATPase activity 1.58256263495768 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.58037625997232 bayes_pls_golite062009
binding 1.49433277484566 bayes_pls_golite062009
SNARE binding 1.43448416553145 bayes_pls_golite062009
syntaxin binding 0.951634505775889 bayes_pls_golite062009
protein binding 0.842371133121818 bayes_pls_golite062009
ATPase activity, coupled 0.787685249362834 bayes_pls_golite062009
catalytic activity 0.767627914425245 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [285-459] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISFKNVAGCD EAKQEIMEFV HFLKNPGKYT KLGAKIPRGA ILSGPPGTGK TLLAKATAGE  60
   61 ANVPFLSVSG SEFVEMFVGV GASRVRDLFT QARSMAPSII FIDEIDAIGK ERGKGGALGG 120
  121 ANDEREATLN QLLVEMDGFT TSDQVVVLAG TNRPDVLDNA LMRPGRFDRH IQIDS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 516.9897
Match: 1e32A_
Description: Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule motor activity 3.80749143568847 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.61311581579476 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
hydrolase activity 2.55157966585974 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 2.50934147358924 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
microfilament motor activity 2.38215814751368 bayes_pls_golite062009
motor activity 2.32425703346903 bayes_pls_golite062009
binding 2.0681607836408 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.56325751172863 bayes_pls_golite062009
actin-dependent ATPase activity 1.24861649961991 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
ion transmembrane transporter activity 0.977237423302079 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.97313818590443 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.97313818590443 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
nucleic acid binding 0.831762535895849 bayes_pls_golite062009
guanyl nucleotide binding 0.640772201693186 bayes_pls_golite062009
guanyl ribonucleotide binding 0.63468044350616 bayes_pls_golite062009
GTP binding 0.621689261700018 bayes_pls_golite062009
cation transmembrane transporter activity 0.557919489256916 bayes_pls_golite062009
protein transporter activity 0.498432226280822 bayes_pls_golite062009
plus-end-directed microtubule motor activity 0.471293810042041 bayes_pls_golite062009
drug transmembrane transporter activity 0.46842047319323 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
GTPase activity 0.437665353870877 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
protein binding 0.378225828131122 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
0.3586311431823 bayes_pls_golite062009
tubulin binding 0.326239364039846 bayes_pls_golite062009
signal recognition particle binding 0.29390189699022 bayes_pls_golite062009
microtubule binding 0.225323885896927 bayes_pls_golite062009
DNA binding 0.143403729737365 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.123304946374679 bayes_pls_golite062009
transcription regulator activity 0.0147430141176288 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [460-572] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDVNGRQQIY LVHLKRLNLD PLLTDDMNNL SGKLATLTPG FTGADIANAC NEAALIAARH  60
   61 NDPYITIHHF EQAIERVIAG LEKKTRVLSK EEKRSVAYHE AGHAVCGWFL KYA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 516.9897
Match: 1e32A_
Description: Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [573-761] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPLLKVSIIP RGQGALGYAQ YLPPDQYLIS EEQFRHRMIM ALGGRVSEEL HFPSVTSGAH  60
   61 DDFKKVTQMA NAMVTSLGMS PKIGYLSFDQ NDGNFKVNKP FSNKTARTID LEVKSIVDDA 120
  121 HRACTELLTK NLDKVDLVAK ELLRKEAITR EDMIRLLGPR PFKERNEAFE KYLDPKSNTE 180
  181 PPEAPAATN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle