YRC Public Data Repository - Protein Structure Prediction

Protein:	MCM3
Organism:	Saccharomyces cerevisiae
Length:	971 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MCM3.

Description	E-value	Query Range	Subject Range
MCM3 - Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin ... MCM3_YEAST - DNA replication licensing factor MCM3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MC... gi\|151944678 - gi\|151944678\|gb\|EDN62937.1\| minichromosome maintenance-related protein [Saccharomyces cerevisiae YJM... gi\|190405533 - gi\|190405533\|gb\|EDV08800.1\| DNA replication licensing factor MCM3 [Saccharomyces cerevisiae RM11-1a]	0.0	[1..971]	[1..971]
MCM3_SCHPO - DNA replication licensing factor mcm3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mcm3... mcm3 - MCM complex subunit Mcm3	0.0	[18..971]	[7..879]
Mcm3-PA - The gene Minichromosome maintenance 3 is referred to in FlyBase by the symbol Dmel\Mcm3 (CG4206, FBg...	0.0	[52..971]	[2..819]
gi\|434753 - gi\|434753\|dbj\|BAA04642.1\| KIAA0030 [Homo sapiens]	0.0	[22..775]	[171..913]
gi\|2183319 - gi\|2183319\|gb\|AAC16250.1\| BM28 homolog [Mus musculus]	0.0	[22..775]	[161..903]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[69..886]	[5..787]

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Predicted Domain #1

Region A:
Residues: [1-158]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGSTGFDGD ATTFFAPDAV FGDRVRRFQE FLDTFTSYRD SVRSIQVYNS NNAANYNDDQ  60
   61 DDADERDLLG DDDGDDLEKE KKAASSTSLN ILPHRIIISL DDLREFDRSF WSGILVEPAY 120
  121 FIPPAEKALT DLADSMDDVP HPNASAVSSR HPWKLSFK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
nucleic acid binding	4.29626483284963	bayes_pls_golite062009
DNA binding	3.71771169141041	bayes_pls_golite062009
structural constituent of ribosome	3.51998515668903	bayes_pls_golite062009
structural molecule activity	3.29857127235306	bayes_pls_golite062009
structure-specific DNA binding	3.06066809614422	bayes_pls_golite062009
single-stranded DNA binding	3.0183551365402	bayes_pls_golite062009
binding	2.83465364476231	bayes_pls_golite062009
transcription regulator activity	2.10110937001387	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	2.04350689362549	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	2.04350689362549	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	2.04218282227834	bayes_pls_golite062009
DNA replication origin binding	1.84819558112187	bayes_pls_golite062009
telomeric DNA binding	1.7847835613194	bayes_pls_golite062009
single-stranded telomeric DNA binding	1.48033977789232	bayes_pls_golite062009
translation regulator activity	1.46320772716954	bayes_pls_golite062009
translation factor activity, nucleic acid binding	1.40718318783582	bayes_pls_golite062009
transcription repressor activity	1.30343463892105	bayes_pls_golite062009
translation initiation factor activity	1.27539679024898	bayes_pls_golite062009
telomerase inhibitor activity	1.25988289474883	bayes_pls_golite062009
DNA-directed RNA polymerase activity	1.19766815287926	bayes_pls_golite062009
RNA polymerase activity	1.19766815287926	bayes_pls_golite062009
ribonuclease activity	1.19236946227657	bayes_pls_golite062009
transcription factor activity	1.14242112812892	bayes_pls_golite062009
DNA helicase activity	1.12203697857261	bayes_pls_golite062009
ligase activity	1.06979791212194	bayes_pls_golite062009
sequence-specific DNA binding	0.85691075793641	bayes_pls_golite062009
DNA-dependent ATPase activity	0.638831894247026	bayes_pls_golite062009
nuclease activity	0.57381531077345	bayes_pls_golite062009
aspartate-tRNA ligase activity	0.504302440847948	bayes_pls_golite062009
nucleotidyltransferase activity	0.325774164899685	bayes_pls_golite062009
exonuclease activity	0.28313884527829	bayes_pls_golite062009
RNA binding	0.18502033889261	bayes_pls_golite062009
protein binding	0.152645195799531	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	0.125256208482441	bayes_pls_golite062009
exoribonuclease activity	0.109774918833391	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.0954216620147701	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.0179535526984695	bayes_pls_golite062009
helicase activity	0.0121541775159524	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [159-366]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSFGAHALSP RTLTAQHLNK LVSVEGIVTK TSLVRPKLIR SVHYAAKTGR FHYRDYTDAT  60
   61 TTLTTRIPTP AIYPTEDTEG NKLTTEYGYS TFIDHQRITV QEMPEMAPAG QLPRSIDVIL 120
  121 DDDLVDKTKP GDRVNVVGVF KSLGAGGMNQ SNSNTLIGFK TLILGNTVYP LHARSTGVAA 180
  181 RQMLTDFDIR NINKLSKKKD IFDILSQS

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	9.086186
Match:	PF00493
Description:	MCM2/3/5 family

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [367-595]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAPSIYGHDH IKKAILLMLM GGVEKNLENG SHLRGDINIL MVGDPSTAKS QLLRFVLNTA  60
   61 SLAIATTGRG SSGVGLTAAV TTDRETGERR LEAGAMVLAD RGVVCIDEFD KMTDVDRVAI 120
  121 HEVMEQQTVT IAKAGIHTTL NARCSVIAAA NPVFGQYDVN RDPHQNIALP DSLLSRFDLL 180
  181 FVVTDDINEI RDRSISEHVL RTHRYLPPGY LEGEPVRERL NLSLAVGED

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.69897
Match:	1g8pA_
Description:	ATPase subunit of magnesium chelatase, BchI
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [596-669]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADINPEEHSN SGAGVENEGE DDEDHVFEKF NPLLQAGAKL AKNKGNYNGT EIPKLVTIPF  60
   61 LRKYVQYAKE RVIP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.69897
Match:	1g8pA_
Description:	ATPase subunit of magnesium chelatase, BchI
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [670-779]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLTQEAINVI VKNYTDLRND DNTKKSPITA RTLETLIRLA TAHAKVRLSK TVNKVDAKVA  60
   61 ANLLRFALLG EDIGNDIDEE ESEYEEALSK RSPQKSPKKR QRVRQPASNS

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.44
Match:	1g8pA
Description:	ATPase subunit of magnesium chelatase, BchI
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [780-971]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSPIKSTPRR STASSVNATP SSARRILRFQ DDEQNAGEDD NDIMSPLPAD EEAELQRRLQ  60
   61 LGLRVSPRRR EHLHAPEEGS SGPLTEVGTP RLPNVSSAGQ DDEQQQSVIS FDNVEPGTIS 120
  121 TGRLSLISGI IARLMQTEIF EEESYPVASL FERINEELPE EEKFSAQEYL AGLKIMSDRN 180
  181 NLMVADDKVW RV

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: