YRC Public Data Repository - Protein Structure Prediction

Protein:	SEC26
Organism:	Saccharomyces cerevisiae
Length:	973 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEC26.

Description	E-value	Query Range	Subject Range
COPB_YEAST - Coatomer subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC26 PE=1 SV=2 SEC26 - Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and ma...	0.0	[1..973]	[1..973]
gi\|123983328, gi... - gi\|123998029\|gb\|ABM86616.1\| coatomer protein complex, subunit beta 1 [synthetic construct], gi\|12398... COPB1 - coatomer protein complex, subunit beta 1	0.0	[3..966]	[2..952]
COPB_MOUSE - Coatomer subunit beta OS=Mus musculus GN=Copb1 PE=1 SV=1	0.0	[3..966]	[2..952]
COPB_RAT - Coatomer subunit beta OS=Rattus norvegicus GN=Copb1 PE=1 SV=1	0.0	[3..966]	[2..952]
gi\|7447850, gi\|5... - pir\|\|T10678 hypothetical protein F3L17.50 - Arabidopsis thaliana, gi\|7270051\|emb\|CAB79866.1\| putati...	0.0	[4..966]	[7..971]
gi\|50900798, gi\|... - gi\|50900798\|ref\|XP_462832.1\| putative coatmer beta subunit (beta-coat protein) (beta-COP) [Oryza sat...	0.0	[2..966]	[84..1036]
betaCop-PA - The gene Ã?Ã?Â²-coatomer protein is referred to in FlyBase by the symbol Dmel\Ã?Ã?Â²Cop ...	0.0	[5..969]	[3..964]

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Predicted Domain #1

Region A:
Residues: [1-106]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSLSSQPAY TLVFDPSPSM ETYSSTDFQK ALEKGSDEQK IDTMKSILVT MLEGNPMPEL  60
   61 LMHIIRFVMP SKNKELKKLL YFYWEIVPKL AEDGKLRHEM ILVCNA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	266.0
Match:	1gw5B_
Description:	Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein transporter activity	4.58709163830613	bayes_pls_golite062009
clathrin binding	3.32763559990416	bayes_pls_golite062009
binding	2.48958374349477	bayes_pls_golite062009
transporter activity	2.48700774379895	bayes_pls_golite062009
substrate-specific transporter activity	2.26725422172281	bayes_pls_golite062009
protein binding	1.75981610748679	bayes_pls_golite062009
protein transmembrane transporter activity	1.4515576307774	bayes_pls_golite062009
transmembrane transporter activity	1.28481004323799	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.09652988954158	bayes_pls_golite062009
nuclear localization sequence binding	0.661470469730249	bayes_pls_golite062009
signal sequence binding	0.57106697498903	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
ion transmembrane transporter activity	0.248585912061178	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
nuclear export signal receptor activity	0.20777471813851	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.100181463251306	bayes_pls_golite062009
pyrophosphatase activity	0.0635404099346928	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0548082069333885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.052195223119721	bayes_pls_golite062009
cation transmembrane transporter activity	0.0405268469927988	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [107-211]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IQHDLQHPNE YIRGNTLRFL TKLREAELLE QMVPSVLACL EYRHAYVRKY AILAVFSIFK  60
   61 VSEHLLPDAK EIINSFIVAE TDPICKRNAF IGLAELDREN ALHYL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	266.0
Match:	1gw5B_
Description:	Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [212-336]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENNIADIENL DPLLQAVFVQ FIRQDANRTP ALKAQYIELL MELLSTTTSD EVIFETALAL  60
   61 TVLSANPNVL VPAVNKLIDL AVKVSDNNIK LIVLDRIQDI NANNVGALEE LTLDILRVLN 120
  121 AEDLD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	266.0
Match:	1gw5B_
Description:	Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [337-436]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VRSKALDISM DLATSRNAED VVQLLKKELQ TTVNNPDQDK AMQYRQLLIK TIRTVAVNFV  60
   61 EMAASVVSLL LDFIGDLNSV AASGIIAFIK EVIEKYPQLR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	266.0
Match:	1gw5B_
Description:	Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [437-519]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANILENMVQT LDKVRSAKAY RGALWIMGEY AEGESEIQHC WKHIRNSVGE VPILQSEIKK  60
   61 LTQNQEHTEE NEVDATAKPT GPV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	266.0
Match:	1gw5B_
Description:	Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [520-615]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILPDGTYATE SAFDVKTSQK SVTDEERDSR PPIRRFVLSG DFYTAAILAN TIIKLVLKFE  60
   61 NVSKNKTVIN ALKAEALLIL VSIVRVGQSS LVEKKI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	29.154902
Match:	1jpwA_
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [616-789]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEDSLERVMT SISILLDEVN PEEKKEEVKL LEVAFLDTTK SSFKRQIEIA KKNKHKRALK  60
   61 DSCKNIEPID TPISFRQFAG VDSTNVQKDS IEEDLQLAMK GDAIHATSSS SISKLKKIVP 120
  121 LCGFSDPVYA EACITNNQFD VVLDVLLVNQ TKETLKNLHV QFATLGDLKI IDTP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8

Region A:
Residues: [790-973]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKTNVIPHGF HKFTVTVKVS SADTGVIFGN IIYDGAHGED ARYVILNDVH VDIMDYIKPA  60
   61 TADDEHFRTM WNAFEWENKI SVKSQLPTLH AYLRELVKGT NMGILTPSES LGEDDCRFLS 120
  121 CNLYAKSSFG EDALANLCIE KDSKTNDVIG YVRIRSKGQG LALSLGDRVA LIAKKTNKLA 180
  181 LTHV

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: