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View Structure Prediction Details

Protein: EHD3
Organism: Saccharomyces cerevisiae
Length: 500 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EHD3.

Description E-value Query
Range
Subject
Range
gi|151942028 - gi|151942028|gb|EDN60384.1| conserved protein [Saccharomyces cerevisiae YJM789]
EHD3 - 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged ...
HIBCH_YEAST - 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S...
gi|190404991 - gi|190404991|gb|EDV08258.1| hypothetical protein SCRG_00475 [Saccharomyces cerevisiae RM11-1a]
0.0 [1..500] [1..500]
gi|85101280 - gi|85101280|ref|XP_961123.1| hypothetical protein NCU03777 [Neurospora crassa OR74A]
gi|32404930, gi|... - gi|32404930|ref|XP_323078.1| related to enoyl-CoA-hydratase [MIPS] [Neurospora crassa], gi|28922662|...
7.0E-95 [3..488] [23..492]
HIBC1_ARATH - 3-hydroxyisobutyryl-CoA hydrolase 1 OS=Arabidopsis thaliana GN=CHY1 PE=1 SV=1
3.0E-84 [33..420] [5..369]
HIBCH_SCHPO - 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 248...
SPBC2D10.09 - 3-hydroxyisobutyryl-CoA hydrolase
7.0E-80 [1..428] [17..428]
gi|17988842, gi|... - gi|17988842|ref|NP_541475.1| enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxybutyry...
gi|25291860 - pir||AH3571 3-hydroxybutyryl-CoA epimerase (EC 5.1.2.3) [imported] - Brucella melitensis (strain 16M...
8.0E-74 [36..432] [3..409]
gi|217327205, gi... - gi|217327205|ref|ZP_03443288.1| fatty oxidation complex, alpha subunit FadJ [Escherichia coli O157:H...
gi|189368241, gi... - gi|189368241|gb|EDU86657.1| fatty oxidation complex, alpha subunit FadJ [Escherichia coli O157:H7 st...
gi|13362694, gi|... - gi|15832478|ref|NP_311251.1| multifunctional fatty acid oxidation complex subunit alpha [Escherichia...
gi|25291852, gi|... - pir||A85876 probable enzyme Z3604 [imported] - Escherichia coli (strain O157:H7, substrain EDL933),...
gi|15802887, gi|... - gi|15802887|ref|NP_288914.1| multifunctional fatty acid oxidation complex subunit alpha [Escherichia...
FADJ_ECO57 - Fatty acid oxidation complex subunit alpha OS=Escherichia coli O157:H7 GN=fadJ PE=3 SV=1
4.0E-73 [31..446] [1..412]
FADJ_ECOBW - Fatty acid oxidation complex subunit alpha OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=fad...
EG14127 - enoyl-CoA hydratase /epimerase and isomerase /3-hydroxyacyl-CoA dehydrogenase / Multifunctional anaero...
FADJ_ECODH - Fatty acid oxidation complex subunit alpha OS=Escherichia coli (strain K12 / DH10B) GN=fadJ PE=3 SV=...
EG14127 - enoyl-CoA hydratase /epimerase and isomerase /3-hydroxyacyl-CoA dehydrogenase / Multifunctional anaero...
FADJ_ECOLI, YFCX... - (P77399) Putative fatty acid oxidation complex alpha subunit [Includes: Enoyl-CoA hydratase (EC 4.2....
gi|89109161, gi|... - gi|89109161|ref|AP_002941.1| fused enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, dodecenoyl-C...
2.0E-71 [31..446] [1..412]
HADHA - hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), a...
gi|123984943, gi... - gi|123998787|gb|ABM87022.1| hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoy...
6.0E-71 [20..450] [25..468]

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Predicted Domain #1
Region A:
Residues: [1-247]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRNTLKCAQ LSSKYGFKTT TRTFMTTQPQ LNVTDAPPVL FTVQDTARVI TLNRPKKLNA  60
   61 LNAEMSESMF KTLNEYAKSD TTNLVILKSS NRPRSFCAGG DVATVAIFNF NKEFAKSIKF 120
  121 FTDEYSLNFQ IATYLKPIVT FMDGITMGGG VGLSIHTPFR IATENTKWAM PEMDIGFFPD 180
  181 VGSTFALPRI VTLANSNSQM ALYLCLTGEV VTGADAYMLG LASHYVSSEN LDALQKRLGE 240
  241 ISPPFNN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 188.201249
Match: 1dubA_
Description: Enoyl-CoA hydratase (crotonase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
long-chain-3-hydroxyacyl-CoA dehydrogenase activity 4.80462645980977 bayes_pls_golite062009
long-chain-enoyl-CoA hydratase activity 4.09442487131529 bayes_pls_golite062009
CoA carboxylase activity 3.89913842968597 bayes_pls_golite062009
acetyl-CoA carboxylase activity 3.85567083340773 bayes_pls_golite062009
acetyl-CoA C-acyltransferase activity 3.6090947563188 bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds 3.4980371783229 bayes_pls_golite062009
oxidoreductase activity 3.09625241707629 bayes_pls_golite062009
catalytic activity 1.79741889688267 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 1.70038641098437 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 1.65338499044318 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors 1.61759001796638 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.47309297191111 bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity 1.25489401408719 bayes_pls_golite062009
propionyl-CoA carboxylase activity 1.20853698666984 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 0.99118526697655 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.788034697021177 bayes_pls_golite062009
methylcrotonoyl-CoA carboxylase activity 0.718702926356989 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.576163737662951 bayes_pls_golite062009
enoyl-CoA hydratase activity 0.439912268968251 bayes_pls_golite062009
binding 0.355184540089764 bayes_pls_golite062009
L-malate dehydrogenase activity 0.332985872550541 bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity 0.124826575912808 bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity 0.118312276550651 bayes_pls_golite062009
fatty acid synthase activity 0.0962368786590111 bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing C=C bonds 0.0918189681606029 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.0913823272876781 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 0.00644214957417527 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [248-345]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPQSAYFFGM VNESIDEFVS PLPKDYVFKY SNEKLNVIEA CFNLSKNGTI EDIMNNLRQY  60
   61 EGSAEGKAFA QEIKTKLLTK SPSSLQIALR LVQENSRD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 188.201249
Match: 1dubA_
Description: Enoyl-CoA hydratase (crotonase)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [346-433]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HIESAIKRDL YTAANMCMNQ DSLVEFSEAT KHKLIDKQRV PYPWTKKEQL FVSQLTSITS  60
   61 PKPSLPMSLL RNTSNVTWTQ YPYHSKYQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.30103
Match: 3hdhA_
Description: Short chain L-3-hydroxyacyl CoA dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [434-500]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPTEQEIAAY IEKRTNDDTG AKVTEREVLN HFANVIPSRR GKLGIQSLCK IVCERKCEEV  60
   61 NDGLRWK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.829 0.009 fatty acid beta-oxidation a.17.1 p8-MTCP1


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle