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View Structure Prediction Details

Protein: CPR4
Organism: Saccharomyces cerevisiae
Length: 318 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CPR4.

Description E-value Query
Range
Subject
Range
CYPR_YEAST - Peptidyl-prolyl cis-trans isomerase CPR4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
CPR4 - Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide ...
7.0E-81 [1..318] [1..318]
PPID_BOVIN - Peptidyl-prolyl cis-trans isomerase D OS=Bos taurus GN=PPID PE=1 SV=6
1.0E-75 [40..281] [3..253]
PPID_MOUSE - Peptidyl-prolyl cis-trans isomerase D OS=Mus musculus GN=Ppid PE=1 SV=3
9.0E-75 [40..281] [3..253]
gi|123996147, gi... - gi|123996147|gb|ABM85675.1| peptidylprolyl isomerase D (cyclophilin D) [synthetic construct], gi|123...
PPID - peptidylprolyl isomerase D
2.0E-73 [40..281] [3..253]
gi|2981756, gi|2... - gi|2981756|pdb|1AWT|L Chain L, Secypa Complexed With Hagpia, gi|2981755|pdb|1AWT|K Chain K, Secypa C...
gi|2981751|pdb|1... - Chain J, Cypa Complexed With Hagpia, Chain L, Cypa Complexed With Hagpia, Chain I, Cypa Complexed Wi...
1.0E-72 [50..227] [1..164]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
7.0E-72 [50..226] [1..163]

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Predicted Domain #1
Region A:
Residues: [1-264]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWLKSLLLCL YSLVLCQVHA APSSGKQITS KDVDLQKKYE PSPPATHRGI ITIEYFDPVS  60
   61 KSMKEADLTF ELYGTVVPKT VNNFAMLAHG VKAVIEGKDP NDIHTYSYRK TKINKVYPNK 120
  121 YIQGGVVAPD VGPFTVYGPK FDDENFYLKH DRPERLAMAY FGPDSNTSEF IITTKADGNE 180
  181 ELDGKSVVFG QITSGLDQLM DAIQYTETDE YGKPQHELRF LYFVLEILKI SNILDLHAAY 240
  241 TEKVEKFRNG DVSVGSTLEN IFRN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 268.264245
Match: 1dywA_
Description: Cyclophilin (eukaryotic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein deacetylase activity 4.3775483906311 bayes_pls_golite062009
histone deacetylase activity 4.29026678196473 bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity 3.73853378771688 bayes_pls_golite062009
cis-trans isomerase activity 3.66963215732405 bayes_pls_golite062009
deacetylase activity 3.49940864924766 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 3.01511519120932 bayes_pls_golite062009
RNA binding 2.94609837984526 bayes_pls_golite062009
signal sequence binding 2.68460419248567 bayes_pls_golite062009
isomerase activity 1.96529188741504 bayes_pls_golite062009
hydrolase activity 1.57292398066812 bayes_pls_golite062009
binding 1.46018233647024 bayes_pls_golite062009
mRNA binding 1.45537055700871 bayes_pls_golite062009
unfolded protein binding 1.38124355054041 bayes_pls_golite062009
transcription regulator activity 1.26149030245805 bayes_pls_golite062009
peroxisome targeting sequence binding 1.01220052237687 bayes_pls_golite062009
DNA binding 0.9531600253493 bayes_pls_golite062009
nucleic acid binding 0.939772862764466 bayes_pls_golite062009
catalytic activity 0.748655649755714 bayes_pls_golite062009
procollagen-proline dioxygenase activity 0.482467028485988 bayes_pls_golite062009
procollagen-proline 4-dioxygenase activity 0.482467028485988 bayes_pls_golite062009
peptidyl-proline dioxygenase activity 0.482467028485988 bayes_pls_golite062009
peptidyl-proline 4-dioxygenase activity 0.482467028485988 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.408539130322443 bayes_pls_golite062009
transcription factor activity 0.374364600772076 bayes_pls_golite062009
drug binding 0.36339132904137 bayes_pls_golite062009
histone binding 0.268719695649015 bayes_pls_golite062009
protein binding 0.130251391659493 bayes_pls_golite062009
N-acetyltransferase activity 0.105969834846946 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [265-318]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKAYTPLTTS TGTTAYDLNH PISRALMCLT VLGLCFIAYK GMHEKPHTVS LRHK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle