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View Structure Prediction Details

Protein: MCM7
Organism: Saccharomyces cerevisiae
Length: 845 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MCM7.

Description E-value Query
Range
Subject
Range
MCM7 - Component of the hexameric MCM complex, which is important for priming origins of DNA replication in...
0.0 [1..845] [1..845]
MCM7 - minichromosome maintenance complex component 7
gi|123998543, gi... - gi|157929222|gb|ABW03896.1| minichromosome maintenance complex component 7 [synthetic construct], gi...
0.0 [33..804] [3..719]
MCM7_MOUSE - DNA replication licensing factor MCM7 OS=Mus musculus GN=Mcm7 PE=1 SV=1
0.0 [33..804] [3..719]
MCM7_XENLA - (Q91876) DNA replication licensing factor MCM7 (CDC47 homolog) (x.MCM7)
0.0 [34..804] [3..720]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [34..804] [3..720]
mcm7 - MCM complex subunit Mcm7
MCM7_SCHPO - DNA replication licensing factor mcm7 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mcm7...
0.0 [4..805] [2..753]
MCM7_ARATH - DNA replication licensing factor MCM7 OS=Arabidopsis thaliana GN=MCM7 PE=1 SV=2
0.0 [36..804] [1..716]

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Predicted Domain #1
Region A:
Residues: [1-206]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAALPSIQL PVDYNNLFNE ITDFLVTFKQ DTLSSDATRN ENEDENLDAE NIEQHLLEKG  60
   61 PKYMAMLQKV ANRELNSVII DLDDILQYQN EKFLQGTQAD DLVSAIQQNA NHFTELFCRA 120
  121 IDNNMPLPTK EIDYKDDVLD VILNQRRLRN ERMLSDRTNE IRSENLMDTT MDPPSSMNDA 180
  181 LREVVEDETE LFPPNLTRRY FLYFKP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [207-417]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSQNCARRYR KKAISSKPLS VRQIKGDFLG QLITVRGIIT RVSDVKPAVE VIAYTCDQCG  60
   61 YEVFQEVNSR TFTPLSECTS EECSQNQTKG QLFMSTRASK FSAFQECKIQ ELSQQVPVGH 120
  121 IPRSLNIHVN GTLVRSLSPG DIVDVTGIFL PAPYTGFKAL KAGLLTETYL EAQFVRQHKK 180
  181 KFASFSLTSD VEERVMELIT SGDVYNRLAK S

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 8.79588
Match: PF00493
Description: MCM2/3/5 family

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
nucleic acid binding 4.29626483284963 bayes_pls_golite062009
DNA binding 3.71771169141041 bayes_pls_golite062009
structure-specific DNA binding 3.48139490984491 bayes_pls_golite062009
single-stranded DNA binding 3.43027351695641 bayes_pls_golite062009
binding 2.83465364476231 bayes_pls_golite062009
telomerase inhibitor activity 2.77979101622935 bayes_pls_golite062009
structural constituent of ribosome 2.13063800565247 bayes_pls_golite062009
transcription regulator activity 2.10110937001387 bayes_pls_golite062009
structural molecule activity 1.9177190829469 bayes_pls_golite062009
DNA replication origin binding 1.84819558112187 bayes_pls_golite062009
telomeric DNA binding 1.7847835613194 bayes_pls_golite062009
3'-5'-exoribonuclease activity 1.54401231841266 bayes_pls_golite062009
single-stranded telomeric DNA binding 1.48033977789232 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 1.35850109411274 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 1.35845277283398 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 1.35845277283398 bayes_pls_golite062009
transcription repressor activity 1.30343463892105 bayes_pls_golite062009
DNA-directed RNA polymerase activity 1.19766815287926 bayes_pls_golite062009
RNA polymerase activity 1.19766815287926 bayes_pls_golite062009
ribonuclease activity 1.19236946227657 bayes_pls_golite062009
transcription factor activity 1.14242112812892 bayes_pls_golite062009
DNA helicase activity 1.12203697857261 bayes_pls_golite062009
sequence-specific DNA binding 0.85691075793641 bayes_pls_golite062009
DNA-dependent ATPase activity 0.638831894247026 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.583085644017496 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
ligase activity 0.346041081217685 bayes_pls_golite062009
nucleotidyltransferase activity 0.325774164899685 bayes_pls_golite062009
double-stranded DNA binding 0.314881439089948 bayes_pls_golite062009
translation regulator activity 0.31332179848255 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.311535572386606 bayes_pls_golite062009
exonuclease activity 0.28313884527829 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.263197317040851 bayes_pls_golite062009
translation initiation factor activity 0.2080607201312 bayes_pls_golite062009
chromatin binding 0.19409870825073 bayes_pls_golite062009
RNA binding 0.18502033889261 bayes_pls_golite062009
protein binding 0.152645195799531 bayes_pls_golite062009
aspartate-tRNA ligase activity 0.151650064901878 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.125256208482441 bayes_pls_golite062009
exoribonuclease activity 0.109774918833391 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.0954216620147701 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.0179535526984695 bayes_pls_golite062009
helicase activity 0.0121541775159524 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [418-646]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IAPEIYGNLD VKKALLLLLV GGVDKRVGDG MKIRGDINVC LMGDPGVAKS QLLKAICKIS  60
   61 PRGVYTTGKG SSGVGLTAAV MKDPVTDEMI LEGGALVLAD NGICCIDEFD KMDESDRTAI 120
  121 HEVMEQQTIS ISKAVINTNP GARTSILAAA NPLYGRINPR LSPLDNINLP AALLSRFDIL 180
  181 FLMLDIPSRD DDEKLAEHVT YVHMHNKQPD LDFTPVEPSK MREYIAYAK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.522879
Match: 1g8pA_
Description: ATPase subunit of magnesium chelatase, BchI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA clamp loader activity 4.91429252297969 bayes_pls_golite062009
protein-DNA loading ATPase activity 4.80695929076807 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.66107861968804 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
RNA helicase activity 1.63960194106079 bayes_pls_golite062009
DNA replication origin binding 1.62491387774159 bayes_pls_golite062009
ATP-dependent RNA helicase activity 1.61735400124552 bayes_pls_golite062009
RNA-dependent ATPase activity 1.60404584546501 bayes_pls_golite062009
ribonucleotide binding 1.53142082854758 bayes_pls_golite062009
purine nucleotide binding 1.52938239070386 bayes_pls_golite062009
purine ribonucleotide binding 1.52887308780164 bayes_pls_golite062009
nucleotide binding 1.52746968836881 bayes_pls_golite062009
microtubule motor activity 1.35938517416356 bayes_pls_golite062009
ATP binding 1.23942044024113 bayes_pls_golite062009
adenyl ribonucleotide binding 1.21044170258803 bayes_pls_golite062009
structure-specific DNA binding 1.20315703345493 bayes_pls_golite062009
adenyl nucleotide binding 1.19481945569892 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
double-stranded DNA binding 1.05408274676326 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
transcription repressor activity 0.862685397469217 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 0.8469248456592 bayes_pls_golite062009
kinase activity 0.641541011250583 bayes_pls_golite062009
motor activity 0.61636596887462 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.584453361662212 bayes_pls_golite062009
single-stranded DNA binding 0.406600732518248 bayes_pls_golite062009
protein kinase activity 0.351308564667977 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.243902356228423 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.156278588350022 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
mismatched DNA binding 0.13366911641814 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
structural constituent of ribosome 0.089234257580272 bayes_pls_golite062009
3'-5' DNA helicase activity 0.0769112340058804 bayes_pls_golite062009
histone methyltransferase activity (H3-K9 specific) 0.0642842984371965 bayes_pls_golite062009
cytoskeletal protein binding 0.0272673919333979 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.0223627159838333 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [647-760]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKRPVMSEAV NDYVVQAYIR LRQDSKREMD SKFSFGQATP RTLLGIIRLS QALAKLRLAD  60
   61 MVDIDDVEEA LRLVRVSKES LYQETNKSKE DESPTTKIFT IIKKMLQETG KNTL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.522879
Match: 1g8pA_
Description: ATPase subunit of magnesium chelatase, BchI
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [761-845]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYENIVKTVR LRGFTMLQLS NCIQEYSYLN VWHLINEGNT LKFVDDGTMD TDQEDSLVST  60
   61 PKLAPQTTAS ANVSAQDSDI DLQDA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle