Protein: | MCM2 |
Organism: | Saccharomyces cerevisiae |
Length: | 868 amino acids |
Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MCM2.
Description | E-value | Query Range |
Subject Range |
|
0.0 | [1..868] | [1..868] |
|
0.0 | [15..865] | [14..832] |
|
0.0 | [15..864] | [3..821] |
|
0.0 | [14..865] | [3..804] |
|
0.0 | [14..865] | [3..804] |
|
0.0 | [12..864] | [4..846] |
|
0.0 | [7..866] | [5..830] |
Region A: Residues: [1-121] |
1 11 21 31 41 51 | | | | | | 1 MSDNRRRRRE EDDSDSENEL PPSSPQQHFR GGMNPVSSPI GSPDMINPEG DDNEVDDVPD 60 61 IDEVEEQMNE VDLMDDNMYE DYAADHNRDR YDPDQVDDRE QQELSLSERR RIDAQLNERD 120 121 R |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
Region A: Residues: [122-175] |
1 11 21 31 41 51 | | | | | | 1 LLRNVAYIDD EDEEQEGAAQ LDEMGLPVQR RRRRRQYEDL ENSDDDLLSD MDID |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
Term | Confidence | Notes |
nucleic acid binding | 3.99127970564994 | bayes_pls_golite062009 |
DNA binding | 3.53568546959418 | bayes_pls_golite062009 |
structural constituent of ribosome | 3.51998515668903 | bayes_pls_golite062009 |
structural molecule activity | 3.29857127235306 | bayes_pls_golite062009 |
structure-specific DNA binding | 3.06066809614422 | bayes_pls_golite062009 |
single-stranded DNA binding | 3.0183551365402 | bayes_pls_golite062009 |
binding | 2.83465364476231 | bayes_pls_golite062009 |
telomerase inhibitor activity | 2.77979101622935 | bayes_pls_golite062009 |
DNA replication origin binding | 1.84819558112187 | bayes_pls_golite062009 |
transcription regulator activity | 1.84350127337404 | bayes_pls_golite062009 |
telomeric DNA binding | 1.7847835613194 | bayes_pls_golite062009 |
single-stranded telomeric DNA binding | 1.48033977789232 | bayes_pls_golite062009 |
translation regulator activity | 1.46320772716954 | bayes_pls_golite062009 |
translation factor activity, nucleic acid binding | 1.40718318783582 | bayes_pls_golite062009 |
translation initiation factor activity | 1.27539679024898 | bayes_pls_golite062009 |
ribonuclease activity | 1.19236946227657 | bayes_pls_golite062009 |
DNA helicase activity | 1.12203697857261 | bayes_pls_golite062009 |
transcription factor activity | 0.952569279670437 | bayes_pls_golite062009 |
sequence-specific DNA binding | 0.85691075793641 | bayes_pls_golite062009 |
DNA-directed RNA polymerase activity | 0.79554655100991 | bayes_pls_golite062009 |
RNA polymerase activity | 0.79554655100991 | bayes_pls_golite062009 |
DNA-dependent ATPase activity | 0.638831894247026 | bayes_pls_golite062009 |
nuclease activity | 0.57381531077345 | bayes_pls_golite062009 |
aminoacyl-tRNA ligase activity | 0.474251377131502 | bayes_pls_golite062009 |
ligase activity, forming carbon-oxygen bonds | 0.47336621289748 | bayes_pls_golite062009 |
ligase activity, forming aminoacyl-tRNA and related compounds | 0.47336621289748 | bayes_pls_golite062009 |
nucleotidyltransferase activity | 0.325774164899685 | bayes_pls_golite062009 |
exonuclease activity | 0.28313884527829 | bayes_pls_golite062009 |
RNA binding | 0.18502033889261 | bayes_pls_golite062009 |
protein binding | 0.152645195799531 | bayes_pls_golite062009 |
exoribonuclease activity, producing 5'-phosphomonoesters | 0.125256208482441 | bayes_pls_golite062009 |
exoribonuclease activity | 0.109774918833391 | bayes_pls_golite062009 |
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 0.0954216620147701 | bayes_pls_golite062009 |
ATP-dependent DNA helicase activity | 0.0179535526984695 | bayes_pls_golite062009 |
helicase activity | 0.0121541775159524 | bayes_pls_golite062009 |
Region A: Residues: [176-297] |
1 11 21 31 41 51 | | | | | | 1 PLREELTLES LSNVKANSYS EWITQPNVSR TIARELKSFL LEYTDETGRS VYGARIRTLG 60 61 EMNSESLEVN YRHLAESKAI LALFLAKCPE EMLKIFDLVA MEATELHYPD YARIHSEIHV 120 121 RI |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
View | Download | 0.817 | 0.008 | pre-replicative complex assembly | a.118.11 | Cytochrome c oxidase subunit E |
Term | Confidence | Notes |
DNA clamp loader activity | 4.91429252297969 | bayes_pls_golite062009 |
protein-DNA loading ATPase activity | 4.80695929076807 | bayes_pls_golite062009 |
DNA-dependent ATPase activity | 2.72462789867829 | bayes_pls_golite062009 |
general RNA polymerase II transcription factor activity | 2.66107861968804 | bayes_pls_golite062009 |
binding | 2.64537357529343 | bayes_pls_golite062009 |
DNA helicase activity | 2.2817164193758 | bayes_pls_golite062009 |
nucleic acid binding | 2.21184938313192 | bayes_pls_golite062009 |
pyrophosphatase activity | 2.13284212711072 | bayes_pls_golite062009 |
DNA binding | 1.94055378599526 | bayes_pls_golite062009 |
ATP-dependent DNA helicase activity | 1.88455339138556 | bayes_pls_golite062009 |
transcription regulator activity | 1.83584389083042 | bayes_pls_golite062009 |
helicase activity | 1.70242731830224 | bayes_pls_golite062009 |
DNA replication origin binding | 1.62491387774159 | bayes_pls_golite062009 |
structural constituent of ribosome | 1.47858140861683 | bayes_pls_golite062009 |
microtubule motor activity | 1.35938517416356 | bayes_pls_golite062009 |
purine NTP-dependent helicase activity | 1.19311444180077 | bayes_pls_golite062009 |
ATP-dependent helicase activity | 1.19311444180077 | bayes_pls_golite062009 |
catalytic activity | 1.00104173493322 | bayes_pls_golite062009 |
DNA-directed DNA polymerase activity | 0.971476020912368 | bayes_pls_golite062009 |
DNA polymerase activity | 0.928091843881235 | bayes_pls_golite062009 |
purine ribonucleotide binding | 0.923452757551011 | bayes_pls_golite062009 |
ribonucleotide binding | 0.923391844349459 | bayes_pls_golite062009 |
purine nucleotide binding | 0.920821955769652 | bayes_pls_golite062009 |
nucleotide binding | 0.917754212279227 | bayes_pls_golite062009 |
structural molecule activity | 0.86514677273731 | bayes_pls_golite062009 |
structure-specific DNA binding | 0.782430219754236 | bayes_pls_golite062009 |
transcription factor activity | 0.697256579145077 | bayes_pls_golite062009 |
motor activity | 0.61636596887462 | bayes_pls_golite062009 |
double-stranded DNA binding | 0.6071273686445 | bayes_pls_golite062009 |
ATP binding | 0.60527666756293 | bayes_pls_golite062009 |
adenyl ribonucleotide binding | 0.573214556107072 | bayes_pls_golite062009 |
adenyl nucleotide binding | 0.554530910579109 | bayes_pls_golite062009 |
translation regulator activity | 0.29096092258568 | bayes_pls_golite062009 |
translation factor activity, nucleic acid binding | 0.274994961137851 | bayes_pls_golite062009 |
RNA helicase activity | 0.18426050934025 | bayes_pls_golite062009 |
protein binding | 0.170837278876362 | bayes_pls_golite062009 |
nucleoside-triphosphatase activity | 0.147579541298736 | bayes_pls_golite062009 |
RNA-dependent ATPase activity | 0.14606996093053 | bayes_pls_golite062009 |
ATP-dependent RNA helicase activity | 0.13050483816765 | bayes_pls_golite062009 |
hydrolase activity, acting on acid anhydrides | 0.113504049290503 | bayes_pls_golite062009 |
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.111293884322157 | bayes_pls_golite062009 |
3'-5' DNA helicase activity | 0.0769112340058804 | bayes_pls_golite062009 |
cytoskeletal protein binding | 0.0272673919333979 | bayes_pls_golite062009 |
Region A: Residues: [298-477] |
1 11 21 31 41 51 | | | | | | 1 SDFPTIYSLR ELRESNLSSL VRVTGVVTRR TGVFPQLKYV KFNCLKCGSI LGPFFQDSNE 60 61 EIRISFCTNC KSKGPFRVNG EKTVYRNYQR VTLQEAPGTV PPGRLPRHRE VILLADLVDV 120 121 SKPGEEVEVT GIYKNNYDGN LNAKNGFPVF ATIIEANSIK RREGNTANEG EEGLDVFSWT 180 181 |
Detection Method: | |
Confidence: | 7.221849 |
Match: | PF00493 |
Description: | MCM2/3/5 family |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
Region A: Residues: [478-496] |
1 11 21 31 41 51 | | | | | | 1 EEEEREFRKI SRDRGIIDK |
Region B: Residues: [688-800] |
1 11 21 31 41 51 | | | | | | 1 DEEADERLAT FVVDSHVRSH PENDEDREGE ELKNNGESAI EQGEDEINEQ LNARQRRLQR 60 61 QRKKEEEISP IPQELLMKYI HYARTKIYPK LHQMDMDKVS RVYADLRRES IST |
Detection Method: | |
Confidence: | 2.522879 |
Match: | 1iqpA_ |
Description: | Replication factor C |
Matching Structure (courtesy of the PDB): |
Region A: Residues: [497-687] |
1 11 21 31 41 51 | | | | | | 1 IISSMAPSIY GHRDIKTAVA CSLFGGVPKN VNGKHSIRGD INVLLLGDPG TAKSQILKYV 60 61 EKTAHRAVFA TGQGASAVGL TASVRKDPIT KEWTLEGGAL VLADKGVCLI DEFDKMNDQD 120 121 RTSIHEAMEQ QSISISKAGI VTTLQARCSI IAAANPNGGR YNSTLPLAQN VSLTEPILSR 180 181 FDILCVVRDL V |
Detection Method: | |
Confidence: | 2.522879 |
Match: | 1iqpA_ |
Description: | Replication factor C |
Matching Structure (courtesy of the PDB): |
Region A: Residues: [801-868] |
1 11 21 31 41 51 | | | | | | 1 GSFPITVRHL ESILRIAESF AKMRLSEFVS SYDLDRAIKV VVDSFVDAQK VSVRRQLRRS 60 61 FAIYTLGH |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.