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View Structure Prediction Details

Protein: CE37371
Organism: Caenorhabditis elegans
Length: 677 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE37371.

Description E-value Query
Range		 Subject
Range
gi|67810531 - gi|67810531|gb|AAY81997.1| endothelin-converting enzyme-1a [Mus musculus]
 698.0 [0..4] [677..62]

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Predicted Domain #1
Region A:
Residues: [1-677] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAVIVFWRM DSAPQAICKT DHNKTRDVCK TAECITLSST LLNWQNTNID PCEDFYEYSC  60
   61 GRYQEHTLND GIRANEKDTI VMKLIRQFVL KNQSTTSNSE NALMLLYEKC SLRYRMENRH 120
  121 QETEVIQREV FENIRKIGSW PIADKNWNSS HFNLNNMLSN MASIHMLPFG LFETRVIELY 180
  181 PMNTTAKQLV IRPTKLKFSI PQEELVRAIR DLLSVNGITS IMKKVKEDVA ESFALDKEIG 240
  241 NIHIDPQPKP ATLSELQKAV PDIDFERIIK SYLNPKTGNW SSLRTKIFSA RFELFFGKNN 300
  301 NLSSIIARTK PRILANYLFL KYIEYAYFFF FDNTKVFSDD DFCTEVVTTS LPRASLRVFV 360
  361 RNHFKKENMA VASEIVEVVK TAYVEIINNS TWLHNSTRES AIEKVVKMKK VIGYTEEYER 420
  421 TGALDEMFET LQLSRSDSFF VLMTKVNRFK IEQLMDFVSS DSLLNPIEPL VMANAFYFPT 480
  481 KNLLNVLVPF LDKPLFDFKY PRYVAMAGVG RVLAHEIGHA FDINGRQTDE IGRTRDWWTR 540
  541 EDTEEYDRRS ECFAEQFTNF KDPSFKGKQN GTEVLAEIIA DALGMEASWI AFKKINLTEE 600
  601 QGLIQFEDHD FGKLYFQVAA LDFCAPSRIE ERYSDQLSHP TNKFRINGAF SNSRAFADTY 660
  661 KCPVGSKMNP VQRCDMF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1dmtA
Description: Neutral endopeptidase (neprilysin)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 5.33358263548929 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.99457783001146 bayes_pls_golite062009
bradykinin receptor binding 4.68498310889748 bayes_pls_golite062009
endopeptidase activity 4.16532996235931 bayes_pls_golite062009
metallopeptidase activity 3.94798058866011 bayes_pls_golite062009
metalloendopeptidase activity 3.43236442601127 bayes_pls_golite062009
peptidyl-dipeptidase activity 3.15882456934259 bayes_pls_golite062009
hydrolase activity 2.61181165622708 bayes_pls_golite062009
angiotensin receptor activity 2.47329778652768 bayes_pls_golite062009
G-protein coupled receptor activity 2.40931483220122 bayes_pls_golite062009
exopeptidase activity 2.07461908743946 bayes_pls_golite062009
receptor binding 2.07222569254168 bayes_pls_golite062009
transmembrane receptor activity 1.71636138555452 bayes_pls_golite062009
receptor activity 1.71573921458029 bayes_pls_golite062009
peptide binding 1.58227634414618 bayes_pls_golite062009
protein binding 1.58118182554863 bayes_pls_golite062009
binding 1.55761777216628 bayes_pls_golite062009
molecular transducer activity 1.42071856700201 bayes_pls_golite062009
signal transducer activity 1.42071856700201 bayes_pls_golite062009
viral receptor activity 1.39617252453036 bayes_pls_golite062009
epoxide hydrolase activity 1.37998417474643 bayes_pls_golite062009
ether hydrolase activity 1.18753073809881 bayes_pls_golite062009
protein complex binding 1.16270782056592 bayes_pls_golite062009
integrin binding 0.93449223670512 bayes_pls_golite062009
catalytic activity 0.891187593353827 bayes_pls_golite062009
interleukin-6 receptor binding 0.711782218042781 bayes_pls_golite062009
cytokine receptor binding 0.61233964043845 bayes_pls_golite062009
peptide receptor activity, G-protein coupled 0.597899738932066 bayes_pls_golite062009
peptide receptor activity 0.574641388356132 bayes_pls_golite062009
zinc ion binding 0.49304764842799 bayes_pls_golite062009
hydrolase activity, acting on ether bonds 0.457157426475929 bayes_pls_golite062009
serine hydrolase activity 0.393080846858665 bayes_pls_golite062009
serine-type peptidase activity 0.374597710524442 bayes_pls_golite062009
growth factor activity 0.259654587796416 bayes_pls_golite062009
serine-type endopeptidase activity 0.252655558968584 bayes_pls_golite062009
aminopeptidase activity 0.21808506596674 bayes_pls_golite062009
transition metal ion binding 0.21514043665594 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
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