YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: gi|11559516
Organism: Plasmodium falciparum
Length: 758 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|11559516.

Description E-value Query
Range
Subject
Range
gi|23479838 - gi|23479838|gb|EAA16562.1| DNA replication licensing factor MCM5 [Plasmodium yoelii yoelii]
gi|82541522 - gi|82541522|ref|XP_724997.1| DNA replication licensing factor MCM5 [Plasmodium yoelii yoelii str. 17...
490.0 [0..1] [736..1]
gi|68072725 - gi|68072725|ref|XP_678276.1| DNA replication licensing factor mcm5 [Plasmodium berghei strain ANKA]
gi|56498689 - gi|56498689|emb|CAI00106.1| DNA replication licensing factor mcm5, putative [Plasmodium berghei]
480.0 [0..1] [736..1]
MCM4_MOUSE - DNA replication licensing factor MCM4 OS=Mus musculus GN=Mcm4 PE=1 SV=1
468.0 [0..31] [756..155]
gi|149019689, gi... - gi|34870013|ref|XP_344049.1| PREDICTED: similar to DNA replication licensing factor MCM4 (CDC21 homo...
466.0 [0..31] [756..155]
gi|940536, gi|10... - gi|940536|emb|CAA52801.1| P1 Cdc21 protein [Homo sapiens], gi|1098112|prf||2115257A Cdc21-like prote...
465.0 [0..31] [756..216]
MCM4_XENTR - DNA replication licensing factor mcm4 OS=Xenopus tropicalis GN=mcm4 PE=2 SV=1
462.0 [0..31] [756..156]

Back

Predicted Domain #1
Region A:
Residues: [1-229]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIGIQEGRAF FNPTRNPNNR PENNIRIEEN LPSLNEVYNY FQDFLSRYSS NTLKEGNLKR  60
   61 TLFENVKNNN FTLDLKLDDI YKQQTVFENN EISATPRSER KMKKPENYSA ILARALSERP 120
  121 LTYLPTIERV CYEVCETANI LNDEDEHLNY IQINLLNTFI RPTPIRGLLA ATQERFVVVP 180
  181 GIIVQASKPQ HKMRKITLQC RYCDHKMSID VPLWRDKPQL PPYCRYSST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.39794
Match: 1ltlA
Description: DNA replication initiator (cdc21/cdc54) N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [230-629]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSSMGLGNA MDSQLGCNGV LEPYVILPNE CTFVDIQSLK MQELPEAVPT GDMPRHLQLN  60
   61 VTRYLCEKMI PGDRVYVHGV LTSYNPNPRP TRADGTNFSY LHVLGFQKYD DMSGNDLNFD 120
  121 VEERNELTLL AAEHNIHEKI FKSIAPELYG MDEVKKACAC LLFGGTRKRI GEETKIRGDI 180
  181 NMLMLGDPSV AKSQILKFVN RCAPVSVYTS GKGSSAAGLT AAVMRDSQGV FSLEGGAMVL 240
  241 ADGGVVCIDE FDKMRDDDVV AIHEAMEQQT ISISKAGITT MLNTRCSVIA AANPSFGSYD 300
  301 DSQDTTYQHD FKTTILSRFD IIFLLRNKQD VEKDTLLCNH IVALHASKHK SQEGEIPLSK 360
  361 LTRYIQYAKR EIAPLLSKEA RDSLRNFYVQ TRAEYRGDRR 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.0
Match: 1qvrA
Description: Crystal Structure Analysis of ClpB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA clamp loader activity 4.91429252297969 bayes_pls_golite062009
protein-DNA loading ATPase activity 4.80695929076807 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.66107861968804 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
telomeric DNA binding 2.0142766759353 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
microtubule motor activity 1.6537049553461 bayes_pls_golite062009
DNA replication origin binding 1.62491387774159 bayes_pls_golite062009
structural constituent of ribosome 1.47858140861683 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
motor activity 1.14667913749579 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.05990253628867 bayes_pls_golite062009
histone acetyltransferase activity 1.05990253628867 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
transcription activator activity 0.889929694023098 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
structural molecule activity 0.86514677273731 bayes_pls_golite062009
transcription repressor activity 0.862685397469217 bayes_pls_golite062009
structure-specific DNA binding 0.782430219754236 bayes_pls_golite062009
single-stranded telomeric DNA binding 0.700780808446722 bayes_pls_golite062009
double-stranded DNA binding 0.6071273686445 bayes_pls_golite062009
purine nucleotide binding 0.569910969126728 bayes_pls_golite062009
purine ribonucleotide binding 0.568840867400671 bayes_pls_golite062009
ribonucleotide binding 0.568779924702229 bayes_pls_golite062009
nucleotide binding 0.564275755355315 bayes_pls_golite062009
sequence-specific DNA binding 0.543891899378373 bayes_pls_golite062009
cytoskeletal protein binding 0.500462538667228 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
four-way junction helicase activity 0.26252931460003 bayes_pls_golite062009
ATP binding 0.1860481660648 bayes_pls_golite062009
exodeoxyribonuclease V activity 0.185603938981231 bayes_pls_golite062009
RNA helicase activity 0.18426050934025 bayes_pls_golite062009
adenyl ribonucleotide binding 0.152859582615242 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
RNA-dependent ATPase activity 0.14606996093053 bayes_pls_golite062009
adenyl nucleotide binding 0.138615225841109 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.13050483816765 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
3'-5' DNA helicase activity 0.0769112340058804 bayes_pls_golite062009
actin binding 0.00482938540552702 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [630-758]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVTKKIPITL RQLESLIRLA ESFAKMELSQ FATDKHVQMS IDLFSASTAE TAKQCLIFET  60
   61 MSPLEQKAVK QAEDAILGRL GKGQRASRVN LFRELQLRGF DRSALSKALA ILIKKGELQE 120
  121 RGDRSVRRT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.69897
Match: 1ojlA
Description: Crystal structure of a sigma54-activator suggests the mechanism for the conformational switch necessary for sigma54 binding
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle