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View Structure Prediction Details

Protein: MDH_SHEON
Organism: Shewanella oneidensis MR-1
Length: 311 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MDH_SHEON.

Description E-value Query
Range		 Subject
Range
gi|73988677 - gi|73988677|ref|XP_534084.2| PREDICTED: similar to L-lactate dehydrogenase A chain (LDH-A) (LDH musc...
 331.0 [0..2] [309..51]
gi|67968888 - gi|67968888|dbj|BAE00801.1| unnamed protein product [Macaca fascicularis]
gi|109107092 - gi|109107092|ref|XP_001084747.1| PREDICTED: lactate dehydrogenase A isoform 6 [Macaca mulatta]
 328.0 [0..2] [309..51]
LDHA_RAT - L-lactate dehydrogenase A chain OS=Rattus norvegicus GN=Ldha PE=1 SV=1
 327.0 [0..2] [309..22]
gi|17368677, gi|... - gi|17368677|sp|Q9BE24|LDHA_MACFA L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M...
 326.0 [0..2] [309..22]
gi|114786449 - gi|114786449|gb|ABI78945.1| LDH-A [Cricetulus griseus]
 326.0 [0..2] [309..22]
gi|55249958 - gb|AAH86251.1| Unknown (protein for MGC:98768) [Xenopus laevis]
LDHA_MOUSE - L-lactate dehydrogenase A chain OS=Mus musculus GN=Ldha PE=1 SV=3
 326.0 [0..2] [309..22]

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Predicted Domain #1
Region A:
Residues: [1-311] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVAVLGAAG GIGQALALLL KTQLPAGSKL SLYDIAPVTP GVAVDLSHIP TAVEIKGFAG  60
   61 EDPTPALVGA DVVLISAGVA RKPGMDRSDL FNINAGIVRN LIEKVAVTCP KALVGIITNP 120
  121 VNTTVAIAAE VMKKAGVYDK NRLFGVTTLD VIRSETFIAE LKGLNVADVK INVIGGHSGV 180
  181 TILPLLSQVE GVTFSDEEVA SLTKRIQNAG TEVVEAKAGG GSATLSMGQA ACRFGMSLVR 240
  241 GLQGEANVVE CAYVDGGSEH AEFFAQPVLL GKNGIEKVLP YGEVSAFEAN ARDSMLDTLK 300
  301 GDIKLGVDFV K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 82.522879
Match: 2pwzA
Description: No description for 2pwzA was found.

Predicted functions:

Term Confidence Notes
malate dehydrogenase activity 4.38786524125089 bayes_pls_golite062009
oxidoreductase activity 3.09625241707629 bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity 3.06391460989761 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors 3.02758902218302 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 2.94416173750168 bayes_pls_golite062009
L-lactate dehydrogenase activity 2.59062377380589 bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent 2.26153457113968 bayes_pls_golite062009
catalytic activity 1.79741889688267 bayes_pls_golite062009
lactate dehydrogenase activity 1.72858895767068 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 1.70038641098437 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 1.65338499044318 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.47309297191111 bayes_pls_golite062009
malic enzyme activity 1.2147813077436 bayes_pls_golite062009
retinol dehydrogenase activity 1.16811519855038 bayes_pls_golite062009
L-malate dehydrogenase activity 1.02646414923682 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 0.99118526697655 bayes_pls_golite062009
transporter activity 0.793769336118517 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.788034697021177 bayes_pls_golite062009
transmembrane transporter activity 0.635891484075352 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.576163737662951 bayes_pls_golite062009
transition metal ion binding 0.516630524306975 bayes_pls_golite062009
NAD or NADH binding 0.44922383360529 bayes_pls_golite062009
enoyl-CoA hydratase activity 0.439912268968251 bayes_pls_golite062009
coenzyme binding 0.35922330382799 bayes_pls_golite062009
binding 0.355184540089764 bayes_pls_golite062009
substrate-specific transporter activity 0.300373102236296 bayes_pls_golite062009
active transmembrane transporter activity 0.239024094835991 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.216422278300306 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.165260811069909 bayes_pls_golite062009
NADPH:quinone reductase activity 0.136079082491021 bayes_pls_golite062009
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity 0.120195861875768 bayes_pls_golite062009
fatty acid synthase activity 0.0962368786590111 bayes_pls_golite062009
ion transmembrane transporter activity 0.0257250793986203 bayes_pls_golite062009
glyoxylate reductase activity 0.0221984076575323 bayes_pls_golite062009
formate dehydrogenase activity 4.92199819939532E-4 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle