YRC Public Data Repository - Protein Structure Prediction

Protein:	MCM5_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	775 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MCM5_YEAST.

Description	E-value	Query Range	Subject Range
MCM5_YEAST - Minichromosome maintenance protein 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCM... gi\|190405333 - gi\|190405333\|gb\|EDV08600.1\| minichromosome maintenance protein 5 [Saccharomyces cerevisiae RM11-1a] MCM5 - Component of the hexameric MCM complex, which is important for priming origins of DNA replication in... gi\|151940981 - gi\|151940981\|gb\|EDN59362.1\| cell division cycle-related protein [Saccharomyces cerevisiae YJM789]	0.0	[1..775]	[1..775]
MCM5_SCHPO - DNA replication licensing factor mcm5 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mcm5... gi\|1709240 - gi\|1709240\|sp\|P41389.2\|MCM5_SCHPO RecName: Full=DNA replication licensing factor mcm5; AltName: Full...	0.0	[3..775]	[7..720]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[3..775]	[7..720]
MCM5 - minichromosome maintenance complex component 5 gi\|208965240, gi... - gi\|208965240\|dbj\|BAG72634.1\| minichromosome maintenance complex component 5 [synthetic construct], g... HGNC:6948\|MIM:60... - maintenance complex component 5	0.0	[3..772]	[4..732]
MCM5A_XENLA - DNA replication licensing factor mcm5-A OS=Xenopus laevis GN=mcm5-a PE=1 SV=2	0.0	[3..772]	[4..733]
MCM5_MOUSE - DNA replication licensing factor MCM5 OS=Mus musculus GN=Mcm5 PE=1 SV=1	0.0	[3..772]	[4..731]

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Predicted Domain #1

Region A:
Residues: [1-122]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFDRPEIYS APVLQGESPN DDDNTEIIKS FKNFILEFRL DSQFIYRDQL RNNILVKNYS  60
   61 LTVNMEHLIG YNEDIYKKLS DEPSDIIPLF ETAITQVAKR ISILSRAQSA NNNDKDPENT 120
  121 SM

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.315	0.486	DNA replication initiation	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.253	0.314	pre-replicative complex assembly	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.257	0.039	pre-replicative complex assembly	c.23.1	CheY-like
View	Download	0.285	0.015	pre-replicative complex assembly	a.118.9	ENTH/VHS domain
View	Download	0.241	N/A	N/A	a.121.1	Tetracyclin repressor-like, C-terminal domain
View	Download	0.228	N/A	N/A	a.123.1	Nuclear receptor ligand-binding domain
View	Download	0.225	N/A	N/A	f.18.1	F1F0 ATP synthase subunit A
View	Download	0.223	N/A	N/A	d.14.1	Ribosomal protein S5 domain 2-like
View	Download	0.223	N/A	N/A	d.58.44	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View	Download	0.223	N/A	N/A	d.92.2	beta-N-acetylhexosaminidase-like domain
View	Download	0.214	N/A	N/A	a.24.3	Cytochromes
View	Download	0.211	N/A	N/A	c.12.1	Ribosomal proteins L15p and L18e
View	Download	0.211	N/A	N/A	d.52.6	BolA-like
View	Download	0.210	N/A	N/A	d.92.2	beta-N-acetylhexosaminidase-like domain
View	Download	0.208	N/A	N/A	a.24.9	alpha-catenin/vinculin

Predicted functions:

Term	Confidence	Notes
telomeric DNA binding	4.81350293592083	bayes_pls_golite062009
telomerase inhibitor activity	4.48082903165152	bayes_pls_golite062009
single-stranded telomeric DNA binding	4.34033743483519	bayes_pls_golite062009
nucleic acid binding	4.29626483284963	bayes_pls_golite062009
DNA binding	3.71771169141041	bayes_pls_golite062009
structural constituent of ribosome	3.51998515668903	bayes_pls_golite062009
structure-specific DNA binding	3.48139490984491	bayes_pls_golite062009
single-stranded DNA binding	3.43027351695641	bayes_pls_golite062009
structural molecule activity	3.29857127235306	bayes_pls_golite062009
binding	2.83465364476231	bayes_pls_golite062009
transcription regulator activity	2.10110937001387	bayes_pls_golite062009
sequence-specific DNA binding	1.9581702424972	bayes_pls_golite062009
DNA replication origin binding	1.84819558112187	bayes_pls_golite062009
translation regulator activity	1.46320772716954	bayes_pls_golite062009
translation factor activity, nucleic acid binding	1.40718318783582	bayes_pls_golite062009
transcription repressor activity	1.30343463892105	bayes_pls_golite062009
translation initiation factor activity	1.27539679024898	bayes_pls_golite062009
transcription activator activity	1.24141936405635	bayes_pls_golite062009
protein binding	1.20309946451799	bayes_pls_golite062009
RNA polymerase activity	1.19766815287926	bayes_pls_golite062009
DNA-directed RNA polymerase activity	1.19766815287926	bayes_pls_golite062009
ribonuclease activity	1.19236946227657	bayes_pls_golite062009
transcription factor activity	1.14242112812892	bayes_pls_golite062009
DNA helicase activity	1.12203697857261	bayes_pls_golite062009
DNA-dependent ATPase activity	0.638831894247026	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.635129001787169	bayes_pls_golite062009
nuclease activity	0.57381531077345	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	0.474251377131502	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	0.47336621289748	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	0.47336621289748	bayes_pls_golite062009
nucleotidyltransferase activity	0.325774164899685	bayes_pls_golite062009
four-way junction helicase activity	0.31769813397725	bayes_pls_golite062009
double-stranded DNA binding	0.314881439089948	bayes_pls_golite062009
exonuclease activity	0.28313884527829	bayes_pls_golite062009
transferase activity	0.249054945579328	bayes_pls_golite062009
RNA binding	0.18502033889261	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	0.125256208482441	bayes_pls_golite062009
exoribonuclease activity	0.109774918833391	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.0954216620147701	bayes_pls_golite062009
DEAD/H-box RNA helicase binding	0.0627405398613412	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.0179535526984695	bayes_pls_golite062009
helicase activity	0.0121541775159524	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [123-373]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTDSLLLNSL PTFQLILNSN ANQIPLRDLD SEHVSKIVRL SGIIISTSVL SSRATYLSIM  60
   61 CRNCRHTTSI TINNFNSITG NTVSLPRSCL STIESESSMA NESNIGDEST KKNCGPDPYI 120
  121 IIHESSKFID QQFLKLQEIP ELVPVGEMPR NLTMTCDRYL TNKVIPGTRV TIVGIYSIYN 180
  181 SKNGAGSGRS GGGNGGSGVA IRTPYIKILG IQSDVETSSI WNSVTMFTEE EEEEFLQLSR 240
  241 NPKLYEILTN S

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	8.823909
Match:	PF00493
Description:	MCM2/3/5 family

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
DNA clamp loader activity	4.91429252297969	bayes_pls_golite062009
protein-DNA loading ATPase activity	4.80695929076807	bayes_pls_golite062009
DNA-dependent ATPase activity	2.72462789867829	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	2.66107861968804	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
nucleic acid binding	2.51683451033161	bayes_pls_golite062009
DNA helicase activity	2.2817164193758	bayes_pls_golite062009
pyrophosphatase activity	2.13284212711072	bayes_pls_golite062009
DNA binding	2.12258000781149	bayes_pls_golite062009
transcription regulator activity	2.09345198747025	bayes_pls_golite062009
telomeric DNA binding	2.0142766759353	bayes_pls_golite062009
ATP-dependent DNA helicase activity	1.88455339138556	bayes_pls_golite062009
helicase activity	1.70242731830224	bayes_pls_golite062009
microtubule motor activity	1.6537049553461	bayes_pls_golite062009
DNA replication origin binding	1.62491387774159	bayes_pls_golite062009
ribonucleotide binding	1.53142082854758	bayes_pls_golite062009
purine nucleotide binding	1.52938239070386	bayes_pls_golite062009
purine ribonucleotide binding	1.52887308780164	bayes_pls_golite062009
nucleotide binding	1.52746968836881	bayes_pls_golite062009
structural constituent of ribosome	1.47858140861683	bayes_pls_golite062009
ATP binding	1.23942044024113	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
adenyl ribonucleotide binding	1.21044170258803	bayes_pls_golite062009
structure-specific DNA binding	1.20315703345493	bayes_pls_golite062009
adenyl nucleotide binding	1.19481945569892	bayes_pls_golite062009
purine NTP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
ATP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
motor activity	1.14667913749579	bayes_pls_golite062009
kinase activity	1.11120928120082	bayes_pls_golite062009
lysine N-acetyltransferase activity	1.05990253628867	bayes_pls_golite062009
histone acetyltransferase activity	1.05990253628867	bayes_pls_golite062009
double-stranded DNA binding	1.05408274676326	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
DNA-directed DNA polymerase activity	0.971476020912368	bayes_pls_golite062009
DNA polymerase activity	0.928091843881235	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.908046791062776	bayes_pls_golite062009
transcription activator activity	0.889929694023098	bayes_pls_golite062009
transcription factor activity	0.887108427603557	bayes_pls_golite062009
structural molecule activity	0.86514677273731	bayes_pls_golite062009
transcription repressor activity	0.862685397469217	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	0.8469248456592	bayes_pls_golite062009
single-stranded telomeric DNA binding	0.700780808446722	bayes_pls_golite062009
sequence-specific DNA binding	0.543891899378373	bayes_pls_golite062009
cytoskeletal protein binding	0.500462538667228	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.421921195209539	bayes_pls_golite062009
single-stranded DNA binding	0.406600732518248	bayes_pls_golite062009
protein kinase activity	0.351308564667977	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
four-way junction helicase activity	0.26252931460003	bayes_pls_golite062009
exodeoxyribonuclease V activity	0.185603938981231	bayes_pls_golite062009
RNA helicase activity	0.18426050934025	bayes_pls_golite062009
transferase activity	0.175269600441384	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.156278588350022	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.147579541298736	bayes_pls_golite062009
RNA-dependent ATPase activity	0.14606996093053	bayes_pls_golite062009
mismatched DNA binding	0.13366911641814	bayes_pls_golite062009
ATP-dependent RNA helicase activity	0.13050483816765	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.113504049290503	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.111293884322157	bayes_pls_golite062009
3'-5' DNA helicase activity	0.0769112340058804	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.0223627159838333	bayes_pls_golite062009
actin binding	0.00482938540552702	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [374-606]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IAPSIFGNED IKKAIVCLLM GGSKKILPDG MRLRGDINVL LLGDPGTAKS QLLKFVEKVS  60
   61 PIAVYTSGKG SSAAGLTASV QRDPMTREFY LEGGAMVLAD GGVVCIDEFD KMRDEDRVAI 120
  121 HEAMEQQTIS IAKAGITTVL NSRTSVLAAA NPIYGRYDDL KSPGDNIDFQ TTILSRFDMI 180
  181 FIVKDDHNEE RDISIANHVI NIHTGNANAM QNQQEENGSE ISIEKMKRYI TYC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	44.522879
Match:	1g8pA_
Description:	ATPase subunit of magnesium chelatase, BchI
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [607-775]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLKCAPRLSP QAAEKLSSNF VTIRKQLLIN ELESTERSSI PITIRQLEAI IRITESLAKL  60
   61 ELSPIAQERH VDEAIRLFQA STMDAASQDP IGGLNQASGT SLSEIRRFEQ ELKRRLPIGW 120
  121 STSYQTLRRE FVDTHRFSQL ALDKALYALE KHETIQLRHQ GQNIYRSGV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	44.522879
Match:	1g8pA_
Description:	ATPase subunit of magnesium chelatase, BchI
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: