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View Structure Prediction Details

Protein: TAD2B_ARATH
Organism: Arabidopsis thaliana
Length: 487 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TAD2B_ARATH.

Description E-value Query
Range		 Subject
Range
gi|42572929 - gi|42572929|ref|NP_974561.1| ADA2B (HOMOLOG OF YEAST ADA2 2B); DNA binding / transcription coactivat...
 378.0 [0..1] [487..1]

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Predicted Domain #1
Region A:
Residues: [1-83] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRSRGNFQN FEDPTQRTRK KKNAANVENF ESTSLVPGAE GGGKYNCDYC QKDITGKIRI  60
   61 KCAVCPDFDL CIECMSVGAE ITP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.154902
Match: 2fc7A
Description: No description for 2fc7A was found.

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 5.9854106358726 bayes_pls_golite062009
binding 2.78710909602478 bayes_pls_golite062009
transcription regulator activity 2.72498741013971 bayes_pls_golite062009
small conjugating protein ligase activity 2.58717417598341 bayes_pls_golite062009
ubiquitin-protein ligase activity 2.47310253065851 bayes_pls_golite062009
nucleic acid binding 2.32387297115017 bayes_pls_golite062009
DNA binding 2.00904221080834 bayes_pls_golite062009
protein binding 1.5975811408548 bayes_pls_golite062009
acid-amino acid ligase activity 1.56027347294593 bayes_pls_golite062009
transcription factor activity 1.22579085356684 bayes_pls_golite062009
transcription factor binding 1.11842175076436 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.90321253993065 bayes_pls_golite062009
ligase activity 0.708614855601548 bayes_pls_golite062009
transcription repressor activity 0.350170315296021 bayes_pls_golite062009
transcription coactivator activity 0.255669498391574 bayes_pls_golite062009
transcription cofactor activity 0.233838999434784 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
transcription activator activity 0.126093965701234 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.024993043379745 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [84-197] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKCDHPYRVM GNLTFPLICP DWSADDEMLL LEGLEIYGLG NWAEVAEHVG TKSKEQCLEH  60
   61 YRNIYLNSPF FPLPDMSHVA GKNRKELQAM AKGRIDDKKA EQNMKEEYPF SPPK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.0
Match: 1h88C
Description: c-Myb, DNA-binding domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
lysine N-acetyltransferase activity 5.80609397811031 bayes_pls_golite062009
histone acetyltransferase activity 5.80609397811031 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 5.49431089902672 bayes_pls_golite062009
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
N-acyltransferase activity 4.57418118498868 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
N-acetyltransferase activity 4.37954729923498 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
acetyltransferase activity 3.80908511328212 bayes_pls_golite062009
acyltransferase activity 3.35206890637362 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.30532537006075 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transferase activity, transferring acyl groups 3.08442186629685 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.85172306285414 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
RNA polymerase activity 1.4315541802752 bayes_pls_golite062009
DNA-directed RNA polymerase activity 1.4315541802752 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
protein deacetylase activity 1.23680480131205 bayes_pls_golite062009
histone deacetylase activity 1.18932416576802 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
DNA-dependent ATPase activity 0.666799964992178 bayes_pls_golite062009
histone binding 0.557787598121402 bayes_pls_golite062009
deacetylase activity 0.530687254192222 bayes_pls_golite062009
nucleotidyltransferase activity 0.292409156157916 bayes_pls_golite062009
telomeric DNA binding 0.284650049512347 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009
cytoskeletal protein binding 0.236060274498333 bayes_pls_golite062009
DNA helicase activity 0.187022204923867 bayes_pls_golite062009
structure-specific DNA binding 0.105174598157041 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [198-404] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKVEDTQKES FVDRSFGGKK PVSTSVNNSL VELSNYNQKR EEFDPEYDND AEQLLAEMEF  60
   61 KENDTPEEHE LKLRVLRIYS KRLDERKRRK EFIIERNLLY PNPFEKDLSQ EEKVQCRRLD 120
  121 VFMRFHSKEE HDELLRNVVS EYRMVKRLKD LKEAQVAGCR STAEAERYLG RKRKRENEEG 180
  181 MNRGKESGQF GQIAGEMGSR PPVQASS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [405-487] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYVNDLDLIG FTESQLLSES EKRLCSEVKL VPPVYLQMQQ VMSHEIFKGN VTKKSDAYSL  60
   61 FKIDPTKVDR VYDMLVKKGI AQL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.69897
Match: 2cujA
Description: Solution structure of SWIRM domain of mouse transcriptional adaptor 2-like
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
lysine N-acetyltransferase activity 5.80609397811031 bayes_pls_golite062009
histone acetyltransferase activity 5.80609397811031 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 5.49431089902672 bayes_pls_golite062009
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
N-acyltransferase activity 4.57418118498868 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
N-acetyltransferase activity 4.37954729923498 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
acetyltransferase activity 3.80908511328212 bayes_pls_golite062009
acyltransferase activity 3.35206890637362 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.30532537006075 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transferase activity, transferring acyl groups 3.08442186629685 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.85172306285414 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
RNA polymerase activity 1.4315541802752 bayes_pls_golite062009
DNA-directed RNA polymerase activity 1.4315541802752 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
protein deacetylase activity 1.23680480131205 bayes_pls_golite062009
histone deacetylase activity 1.18932416576802 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
DNA-dependent ATPase activity 0.666799964992178 bayes_pls_golite062009
histone binding 0.557787598121402 bayes_pls_golite062009
deacetylase activity 0.530687254192222 bayes_pls_golite062009
nucleotidyltransferase activity 0.292409156157916 bayes_pls_golite062009
telomeric DNA binding 0.284650049512347 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009
cytoskeletal protein binding 0.236060274498333 bayes_pls_golite062009
DNA helicase activity 0.187022204923867 bayes_pls_golite062009
structure-specific DNA binding 0.105174598157041 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle