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View Structure Prediction Details

Protein: Nmdar2-PC
Organism: Drosophila melanogaster
Length: 1083 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Nmdar2-PC.

Description E-value Query
Range		 Subject
Range
Nmdar2-PF - The gene NMDA receptor 2 is referred to in FlyBase by the symbol Dmel\Nmdar2 (CG33513, FBgn0053513)....
 573.0 [0..1] [1070..1]

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Predicted Domain #1
Region A:
Residues: [1-76] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMPSRVKLKR GTDGPTPTPT PMPTTMRKHT PIATLNTASC QHNSTTSRRK RILTPPSGPI  60
   61 SLLLLTVLTL LILDTR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [77-597] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SCQGLRLTNG GGSLSKGAAA NKEQLNIGLI APHTNFGKRE YLRSINNAVT GLTKTRGAKL  60
   61 TFLKDYSFEQ KNIHFDMMSL TPSPTAILST LCKEFLRVNV SAILYMMNNE QFGHSTASAQ 120
  121 YFLQLAGYLG IPVISWNADN SGLERRASQS TLQLQLAPSI EHQSAAMLSI LERYKWHQFS 180
  181 VVTSQIAGHD DFVQAVRERV AEMQEHFKFT ILNSIVVTRT SDLMELVNSE ARVMLLYATQ 240
  241 TEAITILRAA EEMKLTGENY VWVVSQSVIE KKDAHSQFPV GMLGVHFDTS SAALMNEISN 300
  301 AIKIYSYGVE AYLTDPANRD RRLTTQSLSC EDEGRGRWDN GEIFFKYLRN VSIEGDLNKP 360
  361 NIEFTADGDL RSAELKIMNL RPSANNKNLV WEEIGVWKSW ETQKLDIRDI AWPGNSHAPP 420
  421 QGVPEKFHLK ITFLEEAPYI NLSPADPVSG KCLMDRGVLC RVAADHEMAA DIDVGQAHRN 480
  481 ESFYQCCSGF CIDLLEKFAE ELGFTYELVR VEDGKWGTLE N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.39794
Match: 2e4uA
Description: No description for 2e4uA was found.

Predicted Domain #3
Region A:
Residues: [598-686] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKWNGLIADL VNRKTDMVLT SLMINTEREA VVDFSEPFME TGIAIVVAKR TGIISPTAFL  60
   61 EPFDTASWML VGIVAIQAAT FMIFLFEWL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1hpbP
Description: Histidine-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [687-905] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPSGYDMKLY LQNTNVTPYR FSLFRTYWLV WAVLFQAAVH VDSPRGFTSR FMTNVWALFA  60
   61 VVFLAIYTAN LAAFMITREE FHEFSGLNDS RLVHPFSHKP SFKFGTIPYS HTDSTIHKYF 120
  121 NVMHNYMRQY NKTSVADGVA AVLNGNLDSF IYDGTVLDYL VAQDEDCRLM TVGSWYAMTG 180
  181 YGLAFSRNSK YVQMFNKRLL EFRANGDLER LRRYWMTGT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.39794
Match: 1pb7A
Description: N-methyl-D-aspartate receptor subunit 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
substrate-specific transmembrane transporter activity 4.68307627076676 bayes_pls_golite062009
ion transmembrane transporter activity 4.22641590829276 bayes_pls_golite062009
amine binding 4.11747486942823 bayes_pls_golite062009
transporter activity 3.92658561501282 bayes_pls_golite062009
transmembrane transporter activity 3.71430307970333 bayes_pls_golite062009
metal ion transmembrane transporter activity 3.45211068541539 bayes_pls_golite062009
substrate-specific transporter activity 3.34421502810243 bayes_pls_golite062009
primary active transmembrane transporter activity 3.33883206510679 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 3.33572158012752 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 3.31947078781945 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 3.3164655425684 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 3.3159417475856 bayes_pls_golite062009
active transmembrane transporter activity 3.25041295044206 bayes_pls_golite062009
transcription regulator activity 3.03357847562258 bayes_pls_golite062009
cation transmembrane transporter activity 2.86948925100516 bayes_pls_golite062009
ATPase activity, coupled 2.65558937563899 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 2.62312131886704 bayes_pls_golite062009
DNA binding 2.61012484342623 bayes_pls_golite062009
transcription factor activity 2.5357143320124 bayes_pls_golite062009
nucleic acid binding 2.48797963503537 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.36995601057551 bayes_pls_golite062009
ATPase activity 2.35388655037218 bayes_pls_golite062009
pyrophosphatase activity 2.29319753274625 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.27317031628667 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.27090852909065 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.24148099938567 bayes_pls_golite062009
binding 2.20249180444367 bayes_pls_golite062009
anion transmembrane transporter activity 2.18878964063845 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 2.17975065094225 bayes_pls_golite062009
peptide binding 2.13614935733644 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 1.78891156577149 bayes_pls_golite062009
receptor activity 1.74349172783363 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 1.64195930233359 bayes_pls_golite062009
molecular transducer activity 1.44487216360172 bayes_pls_golite062009
signal transducer activity 1.44487216360172 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 1.12761240844996 bayes_pls_golite062009
transcription activator activity 1.0083098653988 bayes_pls_golite062009
hydrolase activity 0.999095648881488 bayes_pls_golite062009
protein binding 0.782435650956845 bayes_pls_golite062009
catalytic activity 0.674312982669564 bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity 0.480504240439005 bayes_pls_golite062009
molybdate ion transmembrane transporter activity 0.480504240439005 bayes_pls_golite062009
amine transmembrane transporter activity 0.372828805396439 bayes_pls_golite062009
iron ion transmembrane transporter activity 0.311100382163719 bayes_pls_golite062009
transition metal ion binding 0.263323904110968 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [906-984] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CRPGKQEHKS SDPLALEQFL SAFLLLMAGI LLAALLLLLE HVYFKYIRKR LAKKDGGHCC  60
   61 ALISLSMGKS LTFRGAVFE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [985-1083] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATEILKKHRC NDPICDTHLW KVKHELDMSR LRVRQLEKVM DKHGIKAPQL RLASSSDLLN  60
   61 HHHLKERPPL LGNLSLAASA QDLYRWSYKT EIAEMETVL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle