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Protein Overview: Nmdar2-PC

General Information:
Name(s) found: Nmdar2-PC / FBpp0070276 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene NMDA receptor 2 is referred to in FlyBase by the symbol Dmel\Nmdar2 (CG33513, FBgn0053513). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:1380259..1401842. It has the cytological map location 2B1. Based on sequence similarity, it is predicted to have molecular function</span>: N-methyl-D-aspartate selective glutamate receptor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: ion transport. 5 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1083 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    outer membrane-bounded periplasmic space [IEA]
    Biological Process: ion transport [IEA]
    Molecular Function: extracellular-glutamate-gated ion channel activity [IEA]
    ionotropic glutamate receptor activity [IEA]
    N-methyl-D-aspartate selective glutamate receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMPSRVKLKR GTDGPTPTPT PMPTTMRKHT PIATLNTASC QHNSTTSRRK RILTPPSGPI  60
   61 SLLLLTVLTL LILDTRSCQG LRLTNGGGSL SKGAAANKEQ LNIGLIAPHT NFGKREYLRS 120
  121 INNAVTGLTK TRGAKLTFLK DYSFEQKNIH FDMMSLTPSP TAILSTLCKE FLRVNVSAIL 180
  181 YMMNNEQFGH STASAQYFLQ LAGYLGIPVI SWNADNSGLE RRASQSTLQL QLAPSIEHQS 240
  241 AAMLSILERY KWHQFSVVTS QIAGHDDFVQ AVRERVAEMQ EHFKFTILNS IVVTRTSDLM 300
  301 ELVNSEARVM LLYATQTEAI TILRAAEEMK LTGENYVWVV SQSVIEKKDA HSQFPVGMLG 360
  361 VHFDTSSAAL MNEISNAIKI YSYGVEAYLT DPANRDRRLT TQSLSCEDEG RGRWDNGEIF 420
  421 FKYLRNVSIE GDLNKPNIEF TADGDLRSAE LKIMNLRPSA NNKNLVWEEI GVWKSWETQK 480
  481 LDIRDIAWPG NSHAPPQGVP EKFHLKITFL EEAPYINLSP ADPVSGKCLM DRGVLCRVAA 540
  541 DHEMAADIDV GQAHRNESFY QCCSGFCIDL LEKFAEELGF TYELVRVEDG KWGTLENGKW 600
  601 NGLIADLVNR KTDMVLTSLM INTEREAVVD FSEPFMETGI AIVVAKRTGI ISPTAFLEPF 660
  661 DTASWMLVGI VAIQAATFMI FLFEWLSPSG YDMKLYLQNT NVTPYRFSLF RTYWLVWAVL 720
  721 FQAAVHVDSP RGFTSRFMTN VWALFAVVFL AIYTANLAAF MITREEFHEF SGLNDSRLVH 780
  781 PFSHKPSFKF GTIPYSHTDS TIHKYFNVMH NYMRQYNKTS VADGVAAVLN GNLDSFIYDG 840
  841 TVLDYLVAQD EDCRLMTVGS WYAMTGYGLA FSRNSKYVQM FNKRLLEFRA NGDLERLRRY 900
  901 WMTGTCRPGK QEHKSSDPLA LEQFLSAFLL LMAGILLAAL LLLLEHVYFK YIRKRLAKKD 960
  961 GGHCCALISL SMGKSLTFRG AVFEATEILK KHRCNDPICD THLWKVKHEL DMSRLRVRQL1020
 1021 EKVMDKHGIK APQLRLASSS DLLNHHHLKE RPPLLGNLSL AASAQDLYRW SYKTEIAEME1080
 1081 TVL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..76] deduced N/A No confident structure predictions are available.
    2 View Details [77..597] PSI-BLAST 43.39794 No description for 2e4uA was found.
    3 View Details [598..686] PSI-BLAST 5.0 Histidine-binding protein
    4 View Details [687..905] PSI-BLAST 15.39794 N-methyl-D-aspartate receptor subunit 1
    5 View Details [906..984] MSA 1.425994 View MSA. No confident structure predictions are available.
    6 View Details [985..1083] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • substrate-specific transmembrane transporter activity
    		•  4.68307627076676 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.22641590829276 bayes_pls_golite062009
  • amine binding
    		•  4.11747486942823 bayes_pls_golite062009
  • transporter activity
    		•  3.92658561501282 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.71430307970333 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  3.45211068541539 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.34421502810243 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  3.33883206510679 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  3.33572158012752 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  3.31947078781945 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  3.3164655425684 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  3.3159417475856 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  3.25041295044206 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.03357847562258 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.86948925100516 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.65558937563899 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  2.62312131886704 bayes_pls_golite062009
  • DNA binding
    		•  2.61012484342623 bayes_pls_golite062009
  • transcription factor activity
    		•  2.5357143320124 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.48797963503537 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.36995601057551 bayes_pls_golite062009
  • ATPase activity
    		•  2.35388655037218 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.29319753274625 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.27317031628667 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.27090852909065 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.24148099938567 bayes_pls_golite062009
  • binding
    		•  2.20249180444367 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  2.18878964063845 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  2.17975065094225 bayes_pls_golite062009
  • peptide binding
    		•  2.13614935733644 bayes_pls_golite062009
  • anion transmembrane-transporting ATPase activity
    		•  1.78891156577149 bayes_pls_golite062009
  • receptor activity
    		•  1.74349172783363 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  1.64195930233359 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.44487216360172 bayes_pls_golite062009
  • signal transducer activity
    		•  1.44487216360172 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  1.12761240844996 bayes_pls_golite062009
  • transcription activator activity
    		•  1.0083098653988 bayes_pls_golite062009
  • hydrolase activity
    		•  0.999095648881488 bayes_pls_golite062009
  • protein binding
    		•  0.782435650956845 bayes_pls_golite062009
  • catalytic activity
    		•  0.674312982669564 bayes_pls_golite062009
  • molybdate transmembrane-transporting ATPase activity
    		•  0.480504240439005 bayes_pls_golite062009
  • molybdate ion transmembrane transporter activity
    		•  0.480504240439005 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  0.372828805396439 bayes_pls_golite062009
  • iron ion transmembrane transporter activity
    		•  0.311100382163719 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.263323904110968 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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