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View Protein Complex Details

Complex Overview

From Publication: Qiu J, Noble WS (2008) Predicting Co-Complexed Protein Pairs from Heterogeneous Data. PLoS Comput Biol 4(4): e1000054. doi:10.1371/journal.pcbi.1000054
Notes: Classfier did not use Gene Ontology annotations. [FDR: 0.021] [SVM Score: 0.906227909709]
Complex Size: 2 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
MCM4
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
    		•
  • chromatin binding
  • ATP-dependent DNA helicase activity
    		•
    MCM5
  • replication fork
  • pre-replicative complex
  • cytoplasm
  • MCM complex
    		•
  • DNA replication initiation
  • establishment of chromatin silencing
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
    		•
  • chromatin binding
  • ATP-dependent DNA helicase activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    MCM complex 1.0611E-6 2 7 2 6292
    pre-replicative complex 6.0632E-6 2 16 2 6292
    protein-DNA complex 8.0641E-5 2 57 2 6292
    nuclear chromosome part 9.0721E-4 2 190 2 6292
    nuclear chromosome 1.3075E-3 2 228 2 6292
    chromosomal part 1.413E-3 2 237 2 6292
    nucleoplasm part 1.5102E-3 2 245 2 6292
    nucleoplasm 1.7541E-3 2 264 2 6292
    chromosome 1.8898E-3 2 274 2 6292
    nuclear lumen 5.1728E-3 2 453 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    pre-replicative complex assembly 3.9411E-6 2 13 2 6292
    DNA unwinding involved in replication 4.5979E-6 2 14 2 6292
    DNA geometric change 9.6001E-6 2 20 2 6292
    DNA duplex unwinding 9.6001E-6 2 20 2 6292
    DNA replication initiation 2.6678E-5 2 33 2 6292
    protein-DNA complex assembly 3.744E-5 2 39 2 6292
    DNA conformation change 8.3521E-5 2 58 2 6292
    DNA-dependent DNA replication 1.678E-4 2 82 2 6292
    DNA replication 3.791E-4 2 123 2 6292
    cellular macromolecular complex assembly 8.3223E-4 2 182 2 6292
    establishment of chromatin silencing 9.5344E-4 2 3 1 6292
    cellular macromolecular complex subunit organization 1.6882E-3 2 259 2 6292
    macromolecular complex assembly 1.9877E-3 2 281 2 6292
    macromolecular complex subunit organization 3.2108E-3 2 357 2 6292
    cellular component assembly 3.7349E-3 2 385 2 6292
    DNA metabolic process 8.631E-3 2 585 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    ATP-dependent DNA helicase activity 7.7306E-6 2 18 2 6292
    chromatin binding 2.6678E-5 2 33 2 6292
    DNA helicase activity 2.8346E-5 2 34 2 6292
    ATP-dependent helicase activity 5.6994E-5 2 48 2 6292
    purine NTP-dependent helicase activity 5.6994E-5 2 48 2 6292
    DNA-dependent ATPase activity 7.5032E-5 2 55 2 6292
    helicase activity 1.7194E-4 2 83 2 6292
    ATPase activity, coupled 5.5711E-4 2 149 2 6292
    ATPase activity 1.1194E-3 2 211 2 6292
    nucleoside-triphosphatase activity 2.7262E-3 2 329 2 6292
    hydrolase activity, acting on acid anhydrides 3.1391E-3 2 353 2 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 3.1391E-3 2 353 2 6292
    pyrophosphatase activity 3.1391E-3 2 353 2 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle