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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Ypt53. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 10 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BCY1
  • nucleus
  • cytoplasm
  • response to heat
  • signal transduction
  • pseudohyphal growth
  • response to stress
  • cAMP-dependent protein kinase inhibitor activity
  • CDC33
  • nucleus
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • translational initiation
  • translation initiation factor activity
  • JJJ1
  • cytoplasm
  • mitochondrion
  • cytosol
  • ribosomal large subunit biogenesis
  • regulation of cell size
  • endocytosis
  • Hsp70/Hsc70 protein regulator activity
  • ATPase activator activity
  • MRS6
  • cytoplasm
  • membrane
  • intracellular protein transport
  • GTPase activator activity
  • Rab GTPase binding
  • POR1
  • integral to mitochondrial outer membrane
  • mitochondrion
  • mitochondrial outer membrane
  • ion transport
  • aerobic respiration
  • mitochondrion organization
  • voltage-gated anion channel activity
  • TPK1
  • cytoplasm
  • cAMP-dependent protein kinase complex
  • pseudohyphal growth
  • Ras protein signal transduction
  • protein amino acid phosphorylation
  • cAMP-dependent protein kinase activity
  • protein serine/threonine kinase activity
  • TPK3
  • cytoplasm
  • cAMP-dependent protein kinase complex
  • positive regulation of apoptosis
  • pseudohyphal growth
  • protein amino acid phosphorylation
  • cAMP-dependent protein kinase activity
  • protein serine/threonine kinase activity
  • VPS21
  • mitochondrion
  • late endosome
  • mitochondrial outer membrane
  • endocytosis
  • protein targeting to vacuole
  • GTPase activity
  • YPT52
  • late endosome
  • endocytosis
  • protein targeting to vacuole
  • GTPase activity
  • YPT53
  • late endosome
  • endocytosis
  • protein targeting to vacuole
  • GTPase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    late endosome 4.3833E-6 10 22 3 6292
    cAMP-dependent protein kinase complex 6.8153E-6 10 3 2 6292
    endosome 3.5918E-4 10 94 3 6292
    cytoplasm 3.2692E-3 10 3552 10 6292
    eukaryotic translation initiation factor 4F complex 6.3436E-3 10 4 1 6292
    mitochondrial outer membrane 8.8178E-3 10 92 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    endocytosis 7.0376E-6 10 88 4 6292
    membrane invagination 9.1609E-6 10 94 4 6292
    regulation of cell size 1.7757E-5 10 111 4 6292
    regulation of anatomical structure size 1.9739E-5 10 114 4 6292
    regulation of cellular component size 1.9739E-5 10 114 4 6292
    pseudohyphal growth 1.3725E-4 10 68 3 6292
    protein targeting to vacuole 1.4337E-4 10 69 3 6292
    cellular membrane organization 1.7216E-4 10 198 4 6292
    membrane organization 1.7216E-4 10 198 4 6292
    cell growth 2.4849E-4 10 83 3 6292
    filamentous growth of a population of unicellular organisms 3.1585E-4 10 90 3 6292
    growth of unicellular organism as a thread of attached cells 3.1585E-4 10 90 3 6292
    intracellular protein transport 4.5611E-4 10 255 4 6292
    filamentous growth 5.1175E-4 10 106 3 6292
    protein transport 5.5936E-4 10 269 4 6292
    establishment of protein localization 5.7538E-4 10 271 4 6292
    cellular protein localization 6.0002E-4 10 274 4 6292
    vacuolar transport 6.5001E-4 10 115 3 6292
    cellular macromolecule localization 6.8764E-4 10 284 4 6292
    protein localization 8.7893E-4 10 303 4 6292
    growth 1.2774E-3 10 145 3 6292
    vesicle-mediated transport 1.3563E-3 10 340 4 6292
    transport 1.8418E-3 10 997 6 6292
    establishment of localization 1.954E-3 10 1008 6 6292
    macromolecule localization 2.4161E-3 10 397 4 6292
    localization 2.5596E-3 10 1060 6 6292
    positive regulation of programmed cell death 4.7611E-3 10 3 1 6292
    positive regulation of cell death 4.7611E-3 10 3 1 6292
    positive regulation of apoptosis 4.7611E-3 10 3 1 6292
    protein targeting 5.0796E-3 10 235 3 6292
    regulation of programmed cell death 6.3436E-3 10 4 1 6292
    regulation of cell death 6.3436E-3 10 4 1 6292
    regulation of apoptosis 6.3436E-3 10 4 1 6292
    regulation of biological quality 7.9592E-3 10 551 4 6292
    intracellular transport 8.0627E-3 10 553 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cyclic nucleotide-dependent protein kinase activity 6.8153E-6 10 3 2 6292
    cAMP-dependent protein kinase activity 6.8153E-6 10 3 2 6292
    GTPase activity 9.9146E-5 10 61 3 6292
    cAMP-dependent protein kinase inhibitor activity 1.5893E-3 10 1 1 6292
    Hsp70/Hsc70 protein regulator activity 3.1764E-3 10 2 1 6292
    enzyme regulator activity 3.5489E-3 10 207 3 6292
    enzyme activator activity 4.7574E-3 10 67 2 6292
    voltage-gated anion channel activity 4.7611E-3 10 3 1 6292
    anion channel activity 4.7611E-3 10 3 1 6292
    protein serine/threonine kinase inhibitor activity 6.3436E-3 10 4 1 6292
    Rab GTPase binding 7.9239E-3 10 5 1 6292
    protein serine/threonine kinase activity 8.6334E-3 10 91 2 6292
    nucleoside-triphosphatase regulator activity 9.3816E-3 10 95 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle