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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 2 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
MSH2
  • nucleus
  • nuclear chromosome
    		•
  • removal of nonhomologous ends
  • DNA recombination
  • meiotic gene conversion
  • meiotic mismatch repair
  • mismatch repair
  • chromatin silencing at silent mating-type cassette
  • mitotic recombination
    		•
  • ATPase activity
  • ATP binding
  • double-strand/single-strand DNA junction binding
  • DNA insertion or deletion binding
  • loop DNA binding
  • Y-form DNA binding
  • four-way junction DNA binding
  • guanine/thymine mispair binding
  • single base insertion or deletion binding
    		•
    MSH6
  • nucleus
    		•
  • meiotic mismatch repair
  • mismatch repair
    		•
  • ATPase activity
  • ATP binding
  • four-way junction DNA binding
  • guanine/thymine mispair binding
  • single base insertion or deletion binding
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    meiotic mismatch repair 1.819E-6 2 9 2 6292
    mismatch repair 1.7735E-5 2 27 2 6292
    meiosis I 1.5567E-4 2 79 2 6292
    meiotic gene conversion 3.1786E-4 2 1 1 6292
    meiosis 6.427E-4 2 160 2 6292
    M phase of meiotic cell cycle 6.427E-4 2 160 2 6292
    meiotic cell cycle 6.7534E-4 2 164 2 6292
    DNA repair 9.2646E-4 2 192 2 6292
    response to DNA damage stimulus 1.4011E-3 2 236 2 6292
    removal of nonhomologous ends 1.5888E-3 2 5 1 6292
    DNA catabolic process, endonucleolytic 1.9064E-3 2 6 1 6292
    cellular response to stress 2.1173E-3 2 290 2 6292
    M phase 2.1762E-3 2 294 2 6292
    gene conversion at mating-type locus 3.4937E-3 2 11 1 6292
    cell cycle phase 3.5621E-3 2 376 2 6292
    cellular response to stimulus 3.6193E-3 2 379 2 6292
    DNA catabolic process 4.7627E-3 2 15 1 6292
    mating type switching 5.0798E-3 2 16 1 6292
    cell cycle process 6.0534E-3 2 490 2 6292
    response to stress 6.2277E-3 2 497 2 6292
    mating type determination 6.3477E-3 2 20 1 6292
    sex determination 6.3477E-3 2 20 1 6292
    cell cycle 6.95E-3 2 525 2 6292
    cell fate commitment 7.2981E-3 2 23 1 6292
    DNA metabolic process 8.631E-3 2 585 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    single base insertion or deletion binding 5.0527E-8 2 2 2 6292
    guanine/thymine mispair binding 1.5158E-7 2 3 2 6292
    four-way junction DNA binding 3.0316E-7 2 4 2 6292
    mismatched DNA binding 5.0527E-7 2 5 2 6292
    DNA insertion or deletion binding 5.0527E-7 2 5 2 6292
    DNA secondary structure binding 1.819E-6 2 9 2 6292
    double-stranded DNA binding 1.2783E-5 2 23 2 6292
    ATP binding 1.3945E-5 2 24 2 6292
    adenyl ribonucleotide binding 1.5158E-5 2 25 2 6292
    adenyl nucleotide binding 2.1979E-5 2 30 2 6292
    purine nucleoside binding 2.3495E-5 2 31 2 6292
    nucleoside binding 2.5061E-5 2 32 2 6292
    ribonucleotide binding 4.1432E-5 2 41 2 6292
    purine ribonucleotide binding 4.1432E-5 2 41 2 6292
    structure-specific DNA binding 4.7798E-5 2 44 2 6292
    purine nucleotide binding 6.6999E-5 2 52 2 6292
    nucleotide binding 8.6451E-5 2 59 2 6292
    double-strand/single-strand DNA junction binding 9.5344E-4 2 3 1 6292
    loop DNA binding 9.5344E-4 2 3 1 6292
    Y-form DNA binding 9.5344E-4 2 3 1 6292
    ATPase activity 1.1194E-3 2 211 2 6292
    DNA binding 1.6492E-3 2 256 2 6292
    nucleoside-triphosphatase activity 2.7262E-3 2 329 2 6292
    hydrolase activity, acting on acid anhydrides 3.1391E-3 2 353 2 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 3.1391E-3 2 353 2 6292
    pyrophosphatase activity 3.1391E-3 2 353 2 6292
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