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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 6 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
MEX67
  • cytoplasm
  • nuclear pore
    		•
  • mRNA export from nucleus
    		•
  • RNA binding
  • protein binding
  • structural constituent of nuclear pore
    		•
    NUP120
  • nuclear pore
    		•
  • mRNA export from nucleus
  • rRNA export from nucleus
  • nuclear pore organization
  • snRNP protein import into nucleus
  • mRNA-binding (hnRNP) protein import into nucleus
  • snRNA export from nucleus
  • chromosome localization
  • tRNA export from nucleus
  • NLS-bearing substrate import into nucleus
  • DNA metabolic process
  • protein export from nucleus
  • ribosomal protein import into nucleus
    		•
  • structural molecule activity
    		•
    NUP145
  • nuclear pore
    		•
  • tRNA splicing, via endonucleolytic cleavage and ligation
  • protein export from nucleus
  • ribosomal protein import into nucleus
  • mRNA export from nucleus
  • rRNA export from nucleus
  • nuclear pore organization
  • snRNP protein import into nucleus
  • mRNA-binding (hnRNP) protein import into nucleus
  • snRNA export from nucleus
  • protein import into nucleus
  • chromosome localization
  • tRNA export from nucleus
  • NLS-bearing substrate import into nucleus
    		•
  • RNA binding
  • structural molecule activity
    		•
    NUP84
  • nuclear pore
    		•
  • DNA metabolic process
  • protein export from nucleus
  • response to DNA damage stimulus
  • ribosomal protein import into nucleus
  • mRNA export from nucleus
  • rRNA export from nucleus
  • nuclear envelope organization
  • nuclear pore organization
  • snRNP protein import into nucleus
  • mRNA-binding (hnRNP) protein import into nucleus
  • snRNA export from nucleus
  • chromosome localization
  • tRNA export from nucleus
  • NLS-bearing substrate import into nucleus
    		•
  • structural molecule activity
    		•
    NUP85
  • nuclear pore
    		•
  • mRNA export from nucleus
  • rRNA export from nucleus
  • nuclear envelope organization
  • nuclear pore organization
  • snRNP protein import into nucleus
  • mRNA-binding (hnRNP) protein import into nucleus
  • snRNA export from nucleus
  • tRNA export from nucleus
  • NLS-bearing substrate import into nucleus
  • protein export from nucleus
  • ribosomal protein import into nucleus
    		•
  • structural molecule activity
    		•
    SEH1
  • nuclear pore
    		•
  • mRNA export from nucleus
  • rRNA export from nucleus
  • nuclear pore organization
  • snRNP protein import into nucleus
  • mRNA-binding (hnRNP) protein import into nucleus
  • snRNA export from nucleus
  • tRNA export from nucleus
  • NLS-bearing substrate import into nucleus
  • protein export from nucleus
  • ribosomal protein import into nucleus
    		•
  • structural molecule activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    pore complex 2.368E-13 6 52 6 6292
    nuclear pore 2.368E-13 6 52 6 6292
    nuclear envelope 9.2978E-10 6 199 6 6292
    integral to membrane 4.1861E-9 6 255 6 6292
    intrinsic to membrane 4.9325E-9 6 262 6 6292
    endomembrane system 6.1824E-8 6 398 6 6292
    envelope 2.6008E-7 6 505 6 6292
    organelle envelope 2.6008E-7 6 505 6 6292
    membrane part 1.3292E-6 6 662 6 6292
    nuclear part 2.8697E-5 6 1103 6 6292
    protein complex 3.4445E-5 6 1137 6 6292
    membrane 4.7163E-5 6 1198 6 6292
    macromolecular complex 3.0579E-4 6 1635 6 6292
    nucleus 1.1592E-3 6 2041 6 6292
    organelle part 2.2664E-3 6 2282 6 6292
    intracellular organelle part 2.2664E-3 6 2282 6 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    mRNA export from nucleus 1.2731E-12 6 68 6 6292
    mRNA transport 1.2731E-12 6 68 6 6292
    ribosomal protein import into nucleus 2.4548E-12 6 23 5 6292
    snRNP protein import into nucleus 2.4548E-12 6 23 5 6292
    snRNA export from nucleus 2.4548E-12 6 23 5 6292
    NLS-bearing substrate import into nucleus 2.4548E-12 6 23 5 6292
    snRNA transport 2.4548E-12 6 23 5 6292
    RNA export from nucleus 3.4953E-12 6 80 6 6292
    RNA transport 3.7749E-12 6 81 6 6292
    nucleic acid transport 3.7749E-12 6 81 6 6292
    establishment of RNA localization 3.7749E-12 6 81 6 6292
    mRNA-binding (hnRNP) protein import into nucleus 3.875E-12 6 25 5 6292
    rRNA export from nucleus 5.8863E-12 6 27 5 6292
    rRNA transport 5.8863E-12 6 27 5 6292
    nuclear pore organization 7.165E-12 6 28 5 6292
    tRNA export from nucleus 7.165E-12 6 28 5 6292
    tRNA transport 7.165E-12 6 28 5 6292
    RNA localization 8.2941E-12 6 92 6 6292
    nucleobase, nucleoside, nucleotide and nucleic acid transport 1.0783E-11 6 96 6 6292
    protein export from nucleus 1.4673E-11 6 32 5 6292
    nuclear export 1.6631E-11 6 103 6 6292
    nuclear transport 6.9363E-11 6 130 6 6292
    nucleocytoplasmic transport 6.9363E-11 6 130 6 6292
    nuclear import 1.245E-10 6 48 5 6292
    protein localization in nucleus 1.245E-10 6 48 5 6292
    protein import into nucleus 1.245E-10 6 48 5 6292
    nucleus organization 2.7744E-10 6 56 5 6292
    chromosome localization 1.9272E-9 6 4 3 6292
    protein import 8.0401E-9 6 108 5 6292
    protein localization in organelle 4.1022E-8 6 149 5 6292
    macromolecule localization 6.0892E-8 6 397 6 6292
    protein targeting 4.0569E-7 6 235 5 6292
    intracellular transport 4.4961E-7 6 553 6 6292
    intracellular protein transport 6.1071E-7 6 255 5 6292
    cellular macromolecular complex subunit organization 6.6017E-7 6 259 5 6292
    establishment of localization in cell 7.2771E-7 6 599 6 6292
    protein transport 7.9791E-7 6 269 5 6292
    establishment of protein localization 8.2802E-7 6 271 5 6292
    cellular protein localization 8.7487E-7 6 274 5 6292
    cellular macromolecule localization 1.0465E-6 6 284 5 6292
    cellular localization 1.1153E-6 6 643 6 6292
    protein localization 1.4461E-6 6 303 5 6292
    ribosome biogenesis 2.8028E-6 6 346 5 6292
    macromolecular complex subunit organization 3.2755E-6 6 357 5 6292
    ribonucleoprotein complex biogenesis 4.1287E-6 6 374 5 6292
    transport 1.5629E-5 6 997 6 6292
    nuclear envelope organization 1.5882E-5 6 7 2 6292
    establishment of localization 1.6695E-5 6 1008 6 6292
    localization 2.2593E-5 6 1060 6 6292
    organelle localization 4.6222E-5 6 85 3 6292
    cellular component biogenesis 8.7868E-5 6 694 5 6292
    organelle organization 9.3483E-4 6 1127 5 6292
    cellular component organization 4.7462E-3 6 1582 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    structural molecule activity 2.3452E-8 6 339 6 6292
    structural constituent of nuclear pore 3.8098E-3 6 4 1 6292
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