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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 13 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
COP1
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • FCF2
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • rRNA processing
  • molecular_function
  • FMP23
  • mitochondrion
  • biological_process
  • molecular_function
  • LCB5
  • membrane fraction
  • soluble fraction
  • response to heat
  • calcium-mediated signaling
  • sphingolipid metabolic process
  • D-erythro-sphingosine kinase activity
  • PIP2
  • nucleus
  • peroxisome organization
  • positive regulation of transcription
  • fatty acid metabolic process
  • DNA binding
  • transcription activator activity
  • RET2
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • protein binding
  • RET3
  • COPI vesicle coat
  • retrograde vesicle-mediated transport, Golgi to ER
  • protein binding
  • SCS2
  • integral to membrane
  • endoplasmic reticulum
  • inositol metabolic process
  • protein targeting to ER
  • chromatin silencing at telomere
  • protein binding
  • SEC2
  • cytosol
  • cytoplasmic membrane-bounded vesicle
  • exocytosis
  • guanyl-nucleotide exchange factor activity
  • SEC21
  • endosome
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • SEC26
  • coated vesicle
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • molecular_function
  • SEC27
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • SEC28
  • endosome
  • COPI vesicle coat
  • vesicle coating
  • ER to Golgi vesicle-mediated transport
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    COPI coated vesicle membrane 7.9883E-19 13 9 7 6292
    COPI vesicle coat 7.9883E-19 13 9 7 6292
    Golgi-associated vesicle membrane 2.5237E-16 13 16 7 6292
    COPI-coated vesicle 2.5544E-15 13 21 7 6292
    vesicle coat 1.169E-13 13 34 7 6292
    coated vesicle membrane 1.46E-13 13 35 7 6292
    cytoplasmic vesicle membrane 1.46E-13 13 35 7 6292
    vesicle membrane 1.46E-13 13 35 7 6292
    membrane coat 2.7332E-13 13 38 7 6292
    coated membrane 2.7332E-13 13 38 7 6292
    cytoplasmic vesicle part 3.3283E-13 13 39 7 6292
    Golgi-associated vesicle 4.0309E-13 13 40 7 6292
    Golgi membrane 1.8433E-12 13 49 7 6292
    membrane-bounded vesicle 6.4454E-12 13 107 8 6292
    cytoplasmic vesicle 6.4454E-12 13 107 8 6292
    cytoplasmic membrane-bounded vesicle 6.4454E-12 13 107 8 6292
    vesicle 8.0842E-12 13 110 8 6292
    coated vesicle 8.6578E-11 13 83 7 6292
    Golgi apparatus part 1.1331E-9 13 119 7 6292
    Golgi apparatus 1.4496E-8 13 171 7 6292
    endomembrane system 2.3251E-7 13 398 8 6292
    membrane part 7.2667E-7 13 662 9 6292
    organelle membrane 1.5996E-5 13 692 8 6292
    membrane 1.09E-4 13 1198 9 6292
    protein complex 3.8397E-3 13 1137 7 6292
    cytoplasmic part 6.8899E-3 13 2482 10 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    retrograde vesicle-mediated transport, Golgi to ER 1.0091E-9 13 26 5 6292
    ER to Golgi vesicle-mediated transport 6.9973E-9 13 83 6 6292
    Golgi vesicle transport 1.2811E-8 13 168 7 6292
    vesicle-mediated transport 6.8023E-8 13 340 8 6292
    establishment of localization in cell 3.0557E-7 13 599 9 6292
    cellular localization 5.6494E-7 13 643 9 6292
    intracellular transport 2.9312E-6 13 553 8 6292
    transport 2.3757E-5 13 997 9 6292
    establishment of localization 2.6043E-5 13 1008 9 6292
    localization 3.9627E-5 13 1060 9 6292
    ncRNA 5'-end processing 6.1865E-3 13 3 1 6292
    endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 6.1865E-3 13 3 1 6292
    rRNA 5'-end processing 6.1865E-3 13 3 1 6292
    RNA 5'-end processing 6.1865E-3 13 3 1 6292
    endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 6.1865E-3 13 3 1 6292
    maturation of 5.8S rRNA 8.2408E-3 13 4 1 6292
    cleavage involved in rRNA processing 8.2408E-3 13 4 1 6292
    maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 8.2408E-3 13 4 1 6292
    endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 8.2408E-3 13 4 1 6292
    endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 8.2408E-3 13 4 1 6292
    endonucleolytic cleavage involved in rRNA processing 8.2408E-3 13 4 1 6292
    vesicle coating 8.2408E-3 13 4 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    D-erythro-sphingosine kinase activity 4.1283E-3 13 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle