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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 20 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ALG5
  • endoplasmic reticulum membrane
  • protein amino acid N-linked glycosylation
  • dolichyl-phosphate beta-glucosyltransferase activity
  • BRE5
  • cytoplasm
  • protein deubiquitination
  • molecular_function
  • CSN12
  • signalosome
  • adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
  • molecular_function
  • CUP2
  • nucleus
  • response to copper ion
  • transcription initiation from RNA polymerase II promoter
  • ligand-regulated transcription factor activity
  • DBP7
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • LUG1
  • nucleolus
  • biological_process
  • molecular_function
  • MET10
  • cytoplasm
  • sulfite reductase complex (NADPH)
  • response to drug
  • sulfate assimilation
  • sulfite reductase (NADPH) activity
  • MSC7
  • endoplasmic reticulum
  • reciprocal meiotic recombination
  • molecular_function
  • MSE1
  • mitochondrion
  • glutamyl-tRNA aminoacylation
  • translation
  • glutamate-tRNA ligase activity
  • NOP53
  • nucleus
  • nucleolus
  • ribosomal large subunit export from nucleus
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • NPY1
  • peroxisome
  • cytoplasm
  • NADH metabolic process
  • NAD+ diphosphatase activity
  • PBP4
  • nucleus
  • cytoplasm
  • biological_process
  • molecular_function
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • RRS1
  • nucleus
  • ribosome biogenesis
  • rRNA processing
  • molecular_function
  • SAS5
  • nuclear chromatin
  • nuclear chromosome, telomeric region
  • chromatin silencing at telomere
  • acetyltransferase activity
  • UME6
  • nucleus
  • ascospore formation
  • positive regulation of meiosis
  • reciprocal meiotic recombination
  • response to drug
  • negative regulation of transcription, mitotic
  • histone deacetylation
  • DNA binding
  • histone deacetylase activity
  • transcription regulator activity
  • YGR126W
  • nucleus
  • cytoplasm
  • biological_process
  • molecular_function
  • YHR127W
  • nucleus
  • biological_process
  • molecular_function
  • YPR045C
  • nucleus
  • biological_process
  • molecular_function
  • YRA1
  • transcription export complex
  • mRNA export from nucleus
  • RNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleus 6.3231E-4 20 2041 14 6292
    membrane-bounded organelle 3.5096E-3 20 3771 18 6292
    intracellular membrane-bounded organelle 3.5096E-3 20 3771 18 6292
    nucleolus 3.9018E-3 20 211 4 6292
    sulfite reductase complex (NADPH) 6.3477E-3 20 2 1 6292
    intracellular part 7.7919E-3 20 4938 20 6292
    intracellular 9.0491E-3 20 4975 20 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    processing of 27S pre-rRNA 1.1216E-3 20 16 2 6292
    positive regulation of meiosis 3.1786E-3 20 1 1 6292
    reciprocal meiotic recombination 7.3084E-3 20 41 2 6292
    ribosomal large subunit assembly 7.3084E-3 20 41 2 6292
    glutamyl-tRNA aminoacylation 9.5071E-3 20 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    rRNA binding 1.1216E-3 20 16 2 6292
    dolichyl-phosphate beta-glucosyltransferase activity 3.1786E-3 20 1 1 6292
    7S RNA binding 3.1786E-3 20 1 1 6292
    ligand-regulated transcription factor activity 3.1786E-3 20 1 1 6292
    NAD+ diphosphatase activity 3.1786E-3 20 1 1 6292
    sulfite reductase (NADPH) activity 6.3477E-3 20 2 1 6292
    5S rRNA binding 6.3477E-3 20 2 1 6292
    glutamate-tRNA ligase activity 9.5071E-3 20 3 1 6292

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