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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 15 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRX1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • 5S rRNA binding
  • rRNA primary transcript binding
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • MAK21
  • Noc1p-Noc2p complex
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOC3
  • nucleus
  • Noc2p-Noc3p complex
  • nucleolus
  • DNA replication initiation
  • ribosome biogenesis
  • rRNA processing
  • protein binding
  • chromatin binding
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP12
  • nucleolus
  • rRNA metabolic process
  • RNA binding
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • RLP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 4.6603E-23 15 211 15 6292
    nuclear lumen 5.8229E-18 15 453 15 6292
    organelle lumen 1.7741E-15 15 660 15 6292
    intracellular organelle lumen 1.7741E-15 15 660 15 6292
    membrane-enclosed lumen 4.3281E-15 15 700 15 6292
    non-membrane-bounded organelle 5.0689E-13 15 959 15 6292
    intracellular non-membrane-bounded organelle 5.0689E-13 15 959 15 6292
    nuclear part 4.193E-12 15 1103 15 6292
    preribosome, large subunit precursor 2.6178E-9 15 9 4 6292
    nucleus 4.4738E-8 15 2041 15 6292
    Noc complex 1.0934E-7 15 5 3 6292
    intracellular organelle part 2.3996E-7 15 2282 15 6292
    organelle part 2.3996E-7 15 2282 15 6292
    preribosome 9.3032E-7 15 34 4 6292
    Noc2p-Noc3p complex 5.3053E-6 15 2 2 6292
    Noc1p-Noc2p complex 5.3053E-6 15 2 2 6292
    nucleolar part 1.465E-4 15 45 3 6292
    membrane-bounded organelle 4.5726E-4 15 3771 15 6292
    intracellular membrane-bounded organelle 4.5726E-4 15 3771 15 6292
    90S preribosome 7.0676E-4 15 17 2 6292
    intracellular organelle 1.4392E-3 15 4070 15 6292
    organelle 1.4445E-3 15 4071 15 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 2.5626E-17 15 346 14 6292
    ribonucleoprotein complex biogenesis 7.739E-17 15 374 14 6292
    cellular component biogenesis 4.7289E-13 15 694 14 6292
    ribosomal large subunit biogenesis 5.4383E-11 15 65 7 6292
    rRNA metabolic process 1.1078E-8 15 137 7 6292
    rRNA processing 2.7153E-7 15 128 6 6292
    ncRNA metabolic process 8.4983E-7 15 257 7 6292
    ncRNA processing 5.741E-6 15 215 6 6292
    RNA processing 1.4636E-4 15 380 6 6292
    ribosome assembly 4.1859E-4 15 64 3 6292
    organelle assembly 5.2263E-4 15 69 3 6292
    RNA metabolic process 6.452E-4 15 954 8 6292
    ribonucleoprotein complex assembly 1.212E-3 15 92 3 6292
    establishment of ribosome localization 1.6681E-3 15 26 2 6292
    ribosome localization 1.6681E-3 15 26 2 6292
    ribosomal subunit export from nucleus 1.6681E-3 15 26 2 6292
    ribosomal large subunit assembly 4.1228E-3 15 41 2 6292
    cellular process 5.0732E-3 15 4426 15 6292
    ribosomal subunit assembly 7.324E-3 15 55 2 6292
    establishment of organelle localization 7.324E-3 15 55 2 6292
    cellular macromolecular complex assembly 8.3804E-3 15 182 3 6292
    nucleic acid metabolic process 8.9153E-3 15 1415 8 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    rRNA binding 6.2447E-4 15 16 2 6292
    RNA binding 1.2121E-3 15 367 5 6292
    5S rRNA binding 4.7627E-3 15 2 1 6292
    binding 5.0296E-3 15 1294 8 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle