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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 27 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
PUF4
  • cytoplasm
  • loss of chromatin silencing involved in replicative cell aging
  • protein localization
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPL11B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL12B, RPL12A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • regulation of translation
  • translational termination
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL16A
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL16B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL18A, RPL18B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL21A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL3
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL32
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL9A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS14A
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS2
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • RPS3
  • preribosome, small subunit precursor
  • response to DNA damage stimulus
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS5
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • small ribosomal subunit
  • 90S preribosome
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS8B, RPS8A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • 90S preribosome
  • ribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • translation
  • structural constituent of ribosome
  • RPS9B
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 1.443E-31 27 101 20 6292
    cytosolic part 8.911E-30 27 122 20 6292
    ribosomal subunit 4.9063E-26 27 183 20 6292
    cytosolic large ribosomal subunit 1.1824E-24 27 60 15 6292
    ribonucleoprotein complex 1.0937E-23 27 514 24 6292
    cytosol 4.2689E-22 27 284 20 6292
    ribosome 6.5361E-22 27 290 20 6292
    large ribosomal subunit 2.3871E-20 27 110 15 6292
    macromolecular complex 9.909E-12 27 1635 24 6292
    non-membrane-bounded organelle 1.1701E-11 27 959 20 6292
    intracellular non-membrane-bounded organelle 1.1701E-11 27 959 20 6292
    cytosolic small ribosomal subunit 4.4846E-7 27 38 5 6292
    preribosome 1.1425E-5 27 34 4 6292
    small ribosomal subunit 1.2113E-5 27 73 5 6292
    90S preribosome 4.6048E-5 27 17 3 6292
    organelle part 6.9498E-5 27 2282 20 6292
    intracellular organelle part 6.9498E-5 27 2282 20 6292
    cytoplasmic part 2.7069E-4 27 2482 20 6292
    small nucleolar ribonucleoprotein complex 3.4512E-3 27 72 3 6292
    stress granule 4.2912E-3 27 1 1 6292
    cytoplasm 5.8068E-3 27 3552 22 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 1.7062E-31 27 376 26 6292
    cellular macromolecule biosynthetic process 2.1764E-20 27 1187 27 6292
    macromolecule biosynthetic process 2.2788E-20 27 1189 27 6292
    gene expression 1.8174E-19 27 1283 27 6292
    cellular protein metabolic process 1.9173E-19 27 1074 26 6292
    protein metabolic process 8.2935E-19 27 1136 26 6292
    cellular biosynthetic process 4.2266E-17 27 1567 27 6292
    biosynthetic process 7.7121E-17 27 1602 27 6292
    cellular macromolecule metabolic process 1.202E-12 27 2285 27 6292
    macromolecule metabolic process 2.5449E-12 27 2349 27 6292
    primary metabolic process 7.4598E-10 27 2896 27 6292
    cellular metabolic process 2.6128E-9 27 3033 27 6292
    regulation of translation 2.6444E-9 27 57 7 6292
    posttranscriptional regulation of gene expression 4.315E-9 27 61 7 6292
    metabolic process 7.7439E-9 27 3157 27 6292
    regulation of cellular protein metabolic process 9.4022E-9 27 68 7 6292
    regulation of protein metabolic process 1.7162E-8 27 74 7 6292
    ribosomal subunit assembly 8.6705E-8 27 55 6 6292
    ribosome assembly 2.185E-7 27 64 6 6292
    organelle assembly 3.4437E-7 27 69 6 6292
    ribonucleoprotein complex assembly 1.917E-6 27 92 6 6292
    ribosomal large subunit assembly 2.4442E-5 27 41 4 6292
    ribosome biogenesis 6.8056E-5 27 346 8 6292
    cellular process 7.3243E-5 27 4426 27 6292
    cellular macromolecular complex assembly 9.6208E-5 27 182 6 6292
    ribonucleoprotein complex biogenesis 1.1801E-4 27 374 8 6292
    ribosomal large subunit biogenesis 1.523E-4 27 65 4 6292
    ribosomal small subunit biogenesis 1.7159E-4 27 26 3 6292
    regulation of gene expression 3.9307E-4 27 445 8 6292
    regulation of macromolecule biosynthetic process 4.6399E-4 27 456 8 6292
    regulation of cellular biosynthetic process 5.8561E-4 27 472 8 6292
    regulation of biosynthetic process 5.9401E-4 27 473 8 6292
    regulation of translational fidelity 6.2672E-4 27 9 2 6292
    cellular macromolecular complex subunit organization 6.546E-4 27 259 6 6292
    regulation of macromolecule metabolic process 7.322E-4 27 488 8 6292
    macromolecular complex assembly 1.0057E-3 27 281 6 6292
    regulation of primary metabolic process 1.0333E-3 27 514 8 6292
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1.3436E-3 27 13 2 6292
    regulation of translational elongation 1.3436E-3 27 13 2 6292
    regulation of cellular metabolic process 1.3605E-3 27 536 8 6292
    regulation of metabolic process 1.5528E-3 27 547 8 6292
    ribosomal small subunit assembly 1.5634E-3 27 14 2 6292
    maturation of SSU-rRNA 1.9523E-3 27 59 3 6292
    macromolecular complex subunit organization 3.4234E-3 27 357 6 6292
    response to cycloalkane 4.2912E-3 27 1 1 6292
    response to organic cyclic substance 4.2912E-3 27 1 1 6292
    response to cycloheximide 4.2912E-3 27 1 1 6292
    cellular component assembly 4.9749E-3 27 385 6 6292
    translational elongation 6.7039E-3 27 29 2 6292
    cellular component biogenesis 6.9144E-3 27 694 8 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 2.9057E-38 27 212 26 6292
    structural molecule activity 1.0517E-32 27 339 26 6292
    RNA binding 1.0331E-4 27 367 8 6292
    nucleic acid binding 5.3827E-3 27 666 8 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle