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Protein Overview: HXK2

General Information:
Name(s) found: HXK2 / YGL253W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 486 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    cytosol [IDALink to PubMed articleLink to PubMed article]
    Biological Process: glycolysis [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    regulation of cell size [IMPLink to PubMed article]
    mannose metabolic process [IDALink to PubMed article]
    fructose metabolic process [IMPLink to PubMed article]
    regulation of transcription by glucose [IDALink to PubMed article]
    glucose import [IGILink to PubMed article]
    glucose metabolic process [IMPLink to PubMed article]
    replicative cell aging [IMPLink to PubMed article]
    fructose import [IGILink to PubMed article]
    Molecular Function: hexokinase activity [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVHLGPKKPQ ARKGSMADVP KELMQQIENF EKIFTVPTET LQAVTKHFIS ELEKGLSKKG  60
   61 GNIPMIPGWV MDFPTGKESG DFLAIDLGGT NLRVVLVKLG GDRTFDTTQS KYRLPDAMRT 120
  121 TQNPDELWEF IADSLKAFID EQFPQGISEP IPLGFTFSFP ASQNKINEGI LQRWTKGFDI 180
  181 PNIENHDVVP MLQKQITKRN IPIEVVALIN DTTGTLVASY YTDPETKMGV IFGTGVNGAY 240
  241 YDVCSDIEKL QGKLSDDIPP SAPMAINCEY GSFDNEHVVL PRTKYDITID EESPRPGQQT 300
  301 FEKMSSGYYL GEILRLALMD MYKQGFIFKN QDLSKFDKPF VMDTSYPARI EEDPFENLED 360
  361 TDDLFQNEFG INTTVQERKL IRRLSELIGA RAARLSVCGI AAICQKRGYK TGHIAADGSV 420
  421 YNRYPGFKEK AANALKDIYG WTQTSLDDYP IKIVPAEDGS GAGAAVIAAL AQKRIAEGKS 480
  481 VGIIGA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) HXK2 RTT106 WRS1
    View Details Qiu et al. (2008) GLK1 HXK1 HXK2 PFK2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SDO1 No Comments Hazbun TR, et al. (2003)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HXK2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..31]
    [311..386]    		 PSI-BLAST 11000.0 Hexokinase
    2 View Details [32..310]
    [387..486]    		 PSI-BLAST 11000.0 Hexokinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • kinase activity
    		•  2.81480196738665 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.66634930184926 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.47806699612578 bayes_pls_golite062009
  • structural molecule activity
    		•  2.37892721989886 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  2.33338276303563 bayes_pls_golite062009
  • binding
    		•  2.11855816699924 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09111975841662 bayes_pls_golite062009
  • protein binding
    		•  2.00711904074672 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.84294882554466 bayes_pls_golite062009
  • hexokinase activity
    		•  1.70516840340504 bayes_pls_golite062009
  • DNA binding
    		•  1.70014394990425 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.69431775343358 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  1.58791290104307 bayes_pls_golite062009
  • glucose binding
    		•  1.58717365638543 bayes_pls_golite062009
  • transferase activity
    		•  1.58048472128722 bayes_pls_golite062009
  • transcription activator activity
    		•  1.35676801272576 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.30214785132007 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.30181101672725 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.27871475799533 bayes_pls_golite062009
  • myosin binding
    		•  1.26046360733002 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.18894708772738 bayes_pls_golite062009
  • transcription factor activity
    		•  1.06678984888387 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.908385694796738 bayes_pls_golite062009
  • mannokinase activity
    		•  0.766256764215041 bayes_pls_golite062009
  • actin binding
    		•  0.742062735414161 bayes_pls_golite062009
  • protein kinase activity
    		•  0.659672620542945 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.574998559133169 bayes_pls_golite062009
  • hydrolase activity
    		•  0.474893704700898 bayes_pls_golite062009
  • glucokinase activity
    		•  0.47468456642723 bayes_pls_golite062009
  • sugar binding
    		•  0.44352406324938 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.426216374317549 bayes_pls_golite062009
  • ATP binding
    		•  0.39408967688855 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.358452809509562 bayes_pls_golite062009
  • ATPase activity
    		•  0.338933039062396 bayes_pls_golite062009
  • catalytic activity
    		•  0.296484721581333 bayes_pls_golite062009
  • monosaccharide binding
    		•  0.20435276425198 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.173637392484485 bayes_pls_golite062009
  • nucleotide binding
    		•  0.168207023557983 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.104339549630743 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.101742118226005 bayes_pls_golite062009
  • chromatin binding
    		•  0.0489277194984092 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.0304569608189402 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle